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AIMS OF THE STUDY
The aim of the thesis was to characterise the circulating antibody-secreting cell (ASC)
response and the mucosal antibody response induced by pneumococcal polysaccharide
(PncPS) antigens
- in adults and toddlers immunised parenterally with pneumococcal vaccines
- in children with pneumococcal acute otitis media (AOM)
and to evaluate
the relevance of the ASC response as a marker of the local IgA
response.
To this end we measured
- the number of PncPS specific ASCs in the peripheral blood
- the PncPS specific antibodies in saliva and nasopharyngeal aspirates (NPA)
and compared the results of the two measurements. The overall immunogenicity of the
vaccines was evaluated by measuring the serum antibody response to PncPS.
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