National Public Health Institute
Laboratory of Vaccine Immunology
Department of Vaccines
Helsinki, Finland

University of Helsinki
Department of Bacteriology and Immunology
Helsinki, Finland

CIRCULATING ANTIBODY-SECRETING CELLS AND SALIVARY ANTIBODIES INDUCED BY THE CAPSULAR POLYSACCHARIDE OF STREPTOCOCCUS PNEUMONIAE

AFTER PARENTERAL IMMUNISATION AND IN ACUTE OTITIS MEDIA

by

Tea Nieminen

ACADEMIC DISSERTATION

To be publicly discussed, by permission of the Medical Faculty of the University of Helsinki in the Niilo Hallman Auditorium of the Hospital for Children and Adolescents, on November 19^th, at 12 noon.

ISBN 951-45-8984-X (HTML version)
Helsingin yliopiston verkkojulkaisut
Helsinki 1999

Publications of the National Public Health Institute
KTL A20/1999
Copyright National Public Health Institute

Supervised by

Docent Helena Käyhty, PhD
Laboratory of Vaccine Immunology
Department of Vaccines
National Public Health Institute
Helsinki, Finland

and

Research Professor Juhani Eskola, MD
Department of Vaccines
National Public Health Institute
Helsinki, Finland

Reviewed by

Research Professor Heikki Arvilommi, MD
Laboratory of Mucosal Immunology
Department in Turku
National Public Health Institute
Turku, Finland

and

Professor Mogens Kilian, ScD
Institute of Medical Microbiology
University of Århus
DK-8000 Århus C
Denmark

Kansanterveyslaitos (KTL)	Folkhälsoinstitutet	National Public Health Institute
Mannerheimintie 166	Mannerheimsvägen 166	Mannerheimintie 166
00300 Helsinki	00300 Helsingfors	00300 Helsinki
puh. vaihde 09-47441	tel. växel 09-47441	phone +358-9-47441
telefax 09-4744 8408	telefax 09-4744 8408	telefax +358-9-4744 8408