From the Department of Neurology
Helsinki University Central Hospital
Helsinki, Finland

Clinical Characteristics and Pathophysiological Mechanisms of Familial Migraine with and without Aura

by

Mikko Kallela

Academic Dissertation

To be publicly discussed with the permission of the Medical Faculty of the University of Helsinki for public examination in Auditorium 4, Helsinki University Central Hospital,Haartmaninkatu 4, on December 15 ^th , 2000, at 12 noon

Helsinki 2000

SUPERVISED BY:

Docent Markus Färkkilä, M.D., Ph.D.
Helsinki University Central Hospital, Department of Neurology
University of Helsinki
Helsinki, Finland

REVIEWED BY:

Professor Carl G. H. Dahlöf, M.D., Ph.D.
Gothenburg Migraine Clinic
Gothenburg, Sweden

and

Professor Bo Larsson, M.D., Ph.D.
Department of Public Health and Caring Sciences
Section of Caring Science
Uppsala University
Uppsala, Sweden

OPPOSED BY:

Docent Reijo Salonen, M.D., Ph.D.
University of Turku
Turku, Finland
Director, Medical Strategy and Communications
Neurology & Psychiatry Therapeutic Development Group
Group Medical Regulatory and Product Strategy
Glaxo Wellcome
North Carolina, USA

ISBN 952-91-2837-1 (nid.)
ISBN 952-91-2838-X (pdf.)
ISBN 952-91-2839-8 (html)

Yliopistopaino
Helsinki 2000