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This thesis is based on the following original publications referred to in the text by their Roman numerals:

I Kinnula, V. L., P. Pietarinen, K. Aalto, I. Virtanen, and K.O. Raivio. Mitochondrial superoxide dismutase induction does not protect epithelial cells during oxidant exposure in vitro. Am. J. Physiol. 268:L71-L77, 1995.

II Pietarinen-Runtti P., K. O. Raivio, M. Saksela, T. M. Asikainen, and V. L. Kinnula. Antioxidant enzyme regulation and resistance to oxidants of human bronchial epithelial cells cultured under hyperoxic conditions. Am. J. Respir. Cell Mol. Biol. 19:286-292, 1998.

III Pietarinen-Runtti, P., K. O. Raivio, K. Linnainmaa, A. Ekman, M. Saksela, and V. L. Kinnula. Differential effects of tumor necrosis factor and asbestos fibers on manganese superoxide dismutase induction and oxidant-induced cytotoxicity in human mesothelial cells. Cell Biol. Toxicol. 12:167-175, 1996.

IV Pietarinen, P., K. O. Raivio, R. B. Devlin, J. D. Crapo, L. Y. Chang, and V. L. Kinnula. Catalase and glutathione reductase protection of human alveolar macrophages during oxidant exposure in vitro. Am. J. Respir. Cell Mol. Biol.13:434-441, 1995.

V Pietarinen-Runtti P., E. Lakari, K. O. Raivio, and V. L. Kinnula. Expression of antioxidative enzymes in human inflammatory cells. Am. J. Physiol. Cell Physiol. In Press.

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