The practical work for this master's thesis was carried out at the Molecular/Cancer Biology Laboratory, Department of Pathology. I am thankful to:
Kari Alitalo, my supervisor, who gave me the possibility to join his international group of scientists.
Martti Tolvanen for helping me with the administrative work, especially for the academical recognition of the credits, which I obtained from the University of Hamburg.
all my collaborators from upstairs, downstairs and the corner lab for all scientific and non-scientific activities: Athina, Dmitry, Eija, Elena, Eola, Erika, Imre, Isto, Juha, Nikke, Matthias, Satu, Suvi, Tarja, Yuji, Vijay and Vladimir, and especially Katri, who introduced me to the secret of successful blunt-end ligations and to many other techniques; Arja, without whom there would be no histological analysis of the transgenic mice and Nina, for assembling pFB1-VEGF-C, out of which most of my other vectors evolved.
my collaborators outside the Haartman Institute: Sirpa Kontusaari (University
of Oulu) for the -MHC
mice, Stefano Mandriotta (University of Geneva) for the RIP
mice, screening and analysis, Xiao-Juan Meng and Merja Lakso (Helsinki,
Viikki Biocenter) for the K14 mice, Ilkka Julkunen (National
Public Health Institute, Helsinki) for his expertise and practical
help in the baculoviral work, and Birgitta Olofsson (Ludwig
Institute, Stockholm) for collaborating in the purification of VEGF-B186.
Pekka Salonen, who still tries to convince me, that Apples are computers (sorry, a system error occurred).
Eija, Mari, Marja-Leena, Paula, Pipsa, Raili and Tapio for providing me with mouse tails, mass preps, copy cards, oligos, mini preps, cells and sequences.
Marzena for being my girlfriend.
Helsinki, October 1996