SCIENTIFIC PUBLICATIONS:

Okoh, M.P. and Vihinen, M. (1999) Pleckstrin homology domains of Tec family protein kinases.Biochem.Biophys.Res.Comm., 265; 151-157.

Hansson, H., Okoh, M.P., Smith, C.I.E., Vihinen, M., and Härd, T. (2001) Intermolecular interactions between the SH3 domain and the proline-rich TH region of Bruton's tyrosine kinase FEBS. Lett. 489; 67-70.

Okoh, M.P. and Vihinen, M. (2002) interaction between Btk TH and SH3 domain. Biopolymers 63; 325-334.

Okoh, M.P., Lappalainen, I., Ollila, J., Stenberg, K., and Vihinen, M. (2001) Structure-function relationships of Bruton's tyrosine kinase (Btk). Recent Res. Dev. Prot. Eng. (in press)

Okoh, M.P., Lappalainen, I., Ollila, J., Stenberg, K., and Vihinen, M. (2001) Bruton's tyrosine Kinase (BTK): A protein implicated in the human X-linked agammaglobulinemia (XLA). Proceedings of the first Mali symposium on applied sciences; 160-

Okoh, M.P., Kainulainen, L., Heiskanen, K., Nizam Isa, M., Varming, K., Ruuskainen, O. and Vihinen, M. (2002) Novel insertions of Bruton tyrosine kinase in patients with X-linked agammaglobulinemia. Human mutat. in press

Okoh, M.P., Lappalainen, I., Stenberg, K., Pasanen, T. and Vihinen, M. (2002) Ligand Binding and Stability of Four N-Terminal Domains of Btk. Manuscript

Thesis:

Ph.D: Molecular and biophysical analysis of the non-catalytic PH, TH, SH3 and SH2 domains of Bruton tyrosine kinase (Btk) protein. (2002) University of Helsinki, Finland

M.Sc: Molecular cloning and functional characterization of spectrin SH3 domain. (1996) University of Oulu, Finland.

Abstracts/Posters:

Okoh, M.P. and Vihinen, M. (2002) Base Excision Sequence Scanning (BESS) An Alternative Method For Immune Deficiency Diagnosis: A Case Study Of Patients With X-Linked Aggammaglobulinemia. Xth meeting of the European Society For Immunodeficiency (ESID). Weimar, Germany

Okoh, M.P. and Vihinen, M (2002) Intra-/Inter molecular interaction of Bruton tyrosine kinase (Btk) involving the TH and The SH3 domain. First International Conference on Biomedical Spectroscopy: From Molecule to Men. Cardiff, UK

Okoh, M.P. and Vihinen, M (2000) Intramolecular regulation of TEC family kinases: Circular dichroism spectroscopy of Btk SH3 domain. Signal transduction pathways and regulation of gene expression as therapeutic target, Luxembourg.

Okoh, M.P. and Vihinen, M (1999) Analysis of ligand induced conformational changes in Btk-SH3 domain. FASEB summer conference on protein tyrosine kinases and phosphorylation, Colorado, USA.


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