Catechol O -Methyltransferase:
Glucuronidation of Inhibitors
and Methylation of Substrates

by

Pia Lautala

Pharmaceutical Chemistry Division
Department of Pharmacy
University of Helsinki
Finland

Academic Dissertation
To be presented with the permission of the Faculty of Science of the
University of Helsinki, for public criticism in Auditorium 1041
of Viikki Biocentre on October 28 ^th , 2000, at 12 o’clock noon

Helsinki 2000

Supervisor:
Prof. Jyrki Taskinen
Division of Pharmaceutical Chemistry
Department of Pharmacy
University of Helsinki
Finland

 

Reviewers:
Prof. Olavi Pelkonen
Department of Pharmacology and Toxicology
Faculty of Medicine
University of Oulu
Finland
Docent Seppo Auriola
Department of Pharmaceutical Chemistry
Faculty of Pharmacy
University of Kuopio
Finland

 

Opponent:
Prof. Matti Lang
Department of Pharmaceutical Biochemistry
Faculty of Pharmacy
University of Uppsala
Sweden

ISBN 951-45-9558-0 (nid.)
ISBN 952-91-2654-9 (pdf)
ISBN 952-91-2655-7 (html)
ISSN 1239-9469

Yliopistopaino
Helsinki 2000