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Cerebral venous thrombosis : Measuring thrombi and sinuses

Show simple item record 2014-04-16T12:00:46Z 2015-07-29T08:24:39Z 2014-04-16T12:00:46Z 2015-07-29T08:24:39Z 2014-04-16
dc.title Cerebral venous thrombosis : Measuring thrombi and sinuses en
ethesis.discipline Neurology en
ethesis.discipline Neurologia fi
ethesis.discipline Neurologi sv
ethesis.department Institutionen för klinisk medicin sv
ethesis.department Institute of Clinical Medicine en
ethesis.department Kliininen laitos fi
ethesis.faculty Faculty of Medicine en
ethesis.faculty Medicinska fakulteten sv
ethesis.faculty Lääketieteellinen tiedekunta fi
ethesis.faculty.URI Helsingfors universitet sv University of Helsinki en Helsingin yliopisto fi
dct.creator Hannikainen, Heikki
dct.issued 2014
dct.language.ISO639-2 eng
dct.abstract Background and purpose: Cerebral venous thrombosis (CVT) is a rare, but serious disease, commonly occurring in young to middle-aged women. It is not yet known whether sinus size and shape confers a risk for thrombosis and whether clot size is correlated with recanalization rates, and because there is no established method for measuring sinus or clot size, we decided to develop one. Patients and methods: CVT patients with 3-D magnetic resonance imaging done early for diagnosis and follow-up imaging around 6 months or later were recruited. Age and sexmatched (1:2) control subjects were patients with various benign headache problems who underwent 3D MRI for excluding CVT or other acute structural disease. All major sinuses were measured in size (area and diameter). All detected clots underwent similar measurement (volume, area and length). Measurements were done with Osirix-software. Results: 25 CVT patients (17 females and 8 males) and 50 control subjects were measured. Volume of the thrombus was either dissolved or reduced in all except one case. Sinus area in CVT patients in follow-up imaging was slightly smaller compared to healthy subjects (P=0.052-0.170). Thrombus volumes were bigger (P=0.009) but also dissolved more effectively in women, with no difference in sex-groups in follow-up imaging. Residual clot volume was bigger in older patients (P=0.007). Other factors did not strongly correlate with thrombus volume. Measurement reproducibility with two individual investigators was good, with best interrater correlation of over 95% in volume measures. Conclusions: This is the first attempt in establishing a volumetric measurement of cerebral sinuses and clots. The methodology may help in estimating probability of recanalization and in trials with interventions such as local thrombolysis and thrombectomy. en
dct.language en
ethesis.language English en
ethesis.language englanti fi
ethesis.language engelska sv
ethesis.supervisor Tatlisumak, Turgut
ethesis.supervisor Putaala, Jukka
ethesis.supervisor Salonen, Oili
ethesis.thesistype Tutkielma (Lääketieteen lisensiaatti) fi
dct.identifier.urn URN:NBN:fi:hulib-201507282502
dc.type.dcmitype Text
ethesis-internal.updated TRUE2

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