Browsing by Subject "AAMI"

Objective: Mild cognitive impairment is state between normal cognition and dementia, but there are several different definitions and criteria for identifying this condition. The purpose of this study is to determine proportion of participants who meet the criteria for different definitions of mild cognitive impairment, namely the Age-Associated Memory Impairment AAMI, Mild Cognitive Impairment MCI and mild Neurocognitive Disorder mNCD in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER). We also evaluate overlapping of the groups who meet the criteria for different definitions and whether they differ in terms of functional performance. In addition, we investigate whether the change in MCI subtype differs in the two-year follow-up between the different subtypes and the intervention and control group. Methods: Quantities of those who met the AAMI, MCI and mNCD criteria were analyzed in the screening phase of the FINGER-study (n=2595, 98 % of participants), at the baseline (n=1073, 85 % of participants) and at two-year follow-up (n=884, 80 % of participants). Subjects were 60-77 years of ages in the beginning of the intervention. Cognition was assessed by the CERAD battery. Results: 61, 67 and 18 % of the subjects met the AAMI criteria, 37, 50 and 23 met the MCI criteria and 37, 45 and 21 % the mNCD criteria (screening, baseline and 2 years follow-up, respectively). The overlap between MCI and mNCD was 90%, between AAMI and MCI 31%, and AAMI and mNCD 34%. The functional performance of those who only met the AAMI criteria was better compared to those who met the criteria of all classifications. None of the MCI subtypes distinguished as more stable than the others after two years follow-up. Those who had met the amnestic MCI criteria at the baseline had more transition to the multidomain MCI in the control group than in the intervention group. Conclusion: Different definitions of mild cognitive impairment identify populations of different sizes and partially different qualities. The results of the study support the idea of equal instability of MCI subtypes. The results provide an indication of multifactorial lifestyle intervention preventing amnestic MCI from developing into multidomain MCI.