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Environmental Enrichment Rescues Plasticity of Serotonergic Neurons

Show simple item record 2019-09-27T10:50:30Z 2019-09-27T10:50:30Z 2019-09-27
dc.title Environmental Enrichment Rescues Plasticity of Serotonergic Neurons en
ethesis.discipline.URI none
ethesis.faculty Bio- ja ympäristötieteellinen tiedekunta fi
ethesis.faculty Faculty of Biological and Environmental Sciences en
ethesis.faculty Bio- och miljövetenskapliga fakulteten sv
ethesis.faculty.URI Helsingin yliopisto fi University of Helsinki en Helsingfors universitet sv
dct.creator Pazos Boubeta, Yago
dct.issued 2019
dct.language.ISO639-2 eng
dct.abstract Neurotrophin, Brain-derived neurotrophic factor (BDNF) and its cognate receptor Tropomyosin receptor kinase B (TrkB), have been concomitantly linked with neuronal plasticity as well as antidepressant mechanism of action. Adult hippocampal neurogenesis involves proliferation and survival of new-born neurons and has been related to antidepressant mechanisms and cognitive improvement. Environmental enrichment (EE) enhances adult hippocampal neurogenesis (AHN) and induces anxiolytic-like effects. This study postulates that EE-living conditions could restore the abnormal serotonergic modulation on AHN of our transgenic mice. In this study, a transgenic mouse line wherein TrkB receptor is compromised from serotonergic neurons and AHN found to be impaired was used. To assess the behavioural effects and the changes in learning and memory tasks produced by 10-weeks of EE, a behavioural battery test was performed. Our results suggested anxiolytic-like effects from EE in the transgenic mice. Likewise, cognitive improvements were also observed in both control and transgenic mice promoted by EE. Moreover, hyperactivity observed in transgenic mice in standard conditions could be rescued, and no phenotypical differences were observed between control and transgenic mice subjected to EE. To further study the effects of EE on AHN, cellular proliferation and survival were studied through the incorporation of BrdU. The results indicate that the abnormal serotonergic regulation of AHN was rescued upon EE-living conditions. Moreover, molecular methods used to measure the alteration of gene expression revealed significant upregulation of genes related to neuronal plasticity and epigenetic modifications. Altogether, these results suggest EE promotes the neuronal plasticity, rescues the impaired regulation of AHN and modulates the genetic expression of the transgenic mice. Findings from this study could provide new insights regarding novel targets that could modulate adult brain plasticity. en
dct.subject Adult hippocampal neurogenesis en
dct.subject Anxiolytic like-effects en
dct.subject BDNF-TrkB signalling en
dct.subject Environmental enrichment en
dct.subject Memory enhancement en
dct.subject Serotonin en
dct.language en
ethesis.language englanti fi
ethesis.language English en
ethesis.language engelska sv
ethesis.supervisor Sahu, Madhusmita Priyadarshini
ethesis.thesistype pro gradu -tutkielmat fi
ethesis.thesistype master's thesis en
ethesis.thesistype pro gradu-avhandlingar sv
dct.identifier.ethesis E-thesisID:257a1592-f5c2-40fd-800d-20c7283dbca0
ethesis-internal.timestamp.reviewStep 2019-08-21 10:31:08:821
ethesis.principalprofessor Voipio, Juha
dct.identifier.urn URN:NBN:fi:hulib-201909273553
dc.type.dcmitype Text
ethesis.facultystudyline Neurotiede fi
ethesis.facultystudyline Neuroscience en
ethesis.facultystudyline Neurovetenskap sv
ethesis.mastersdegreeprogram Neurotieteiden maisteriohjelma fi
ethesis.mastersdegreeprogram Master's Programme in Neuroscience en
ethesis.mastersdegreeprogram Magisterprogrammet i neurovetenskap sv

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