| dc.date.accessioned |
2016-06-09T10:14:48Z |
|
| dc.date.available |
2017-09-07T21:00:36Z |
|
| dc.date.issued |
2016-06-09 |
|
| dc.identifier.uri |
http://hdl.handle.net/123456789/7432 |
|
| dc.title |
Symptomatic Treatment for Uncomplicated Acute Diverticulitis : A Prospective Cohort Study |
en |
| ethesis.discipline |
Gastroenterological Surgery |
en |
| ethesis.discipline |
Gastroenterologinen kirurgia |
fi |
| ethesis.discipline |
Gastroenterologisk kirurgi |
sv |
| ethesis.discipline.URI |
http://data.hulib.helsinki.fi/id/B0e94a64-5dbf-493e-b70c-df1ac19f2387 |
|
| ethesis.faculty |
Medicinska fakulteten |
sv |
| ethesis.faculty |
Lääketieteellinen tiedekunta |
fi |
| ethesis.faculty |
Faculty of Medicine |
en |
| ethesis.faculty.URI |
http://data.hulib.helsinki.fi/id/a4d5aaa2-b5aa-41a7-ba4c-e5e0df7a902d |
|
| ethesis.university.URI |
http://data.hulib.helsinki.fi/id/50ae46d8-7ba9-4821-877c-c994c78b0d97 |
|
| ethesis.university |
Helsingfors universitet |
sv |
| ethesis.university |
University of Helsinki |
en |
| ethesis.university |
Helsingin yliopisto |
fi |
| dct.creator |
Mali, Juha |
|
| dct.issued |
2016 |
|
| dct.language.ISO639-2 |
eng |
|
| dct.abstract |
Background:
Even though evidence for non-antibiotic treatment of uncomplicated diverticulitis exists, it has not gained widespread adoption.
Objective:
The aim of this prospective single-arm study was to analyze safety and efficacy of symptomatic (non-antibiotic) treatment for uncomplicated diverticulitis during a 30-day follow-up period.
Design:
Single-arm prospective trial (ClinicalTrials.gov ID NCT02219698).
Settings:
An academic teaching hospital functioning as both a tertiary and secondary care referral center.
Patients:
Patients, who had computer tomography verified uncomplicated acute colonic diverticulitis (including diverticulitis with pericolic air), were evaluated for the study. Patients with ongoing antibiotic therapy, immunosuppression, suspicion of peritonitis, organ dysfunction, pregnancy, or other infections requiring antibiotics were excluded.
Interventions:
Symptomatic in- or outpatient treatment consisted of mild analgesics (non-steroidal anti inflammatory drug or paracetamol).
Main Outcome Measures:
The incidence of complicated diverticulitis was the primary outcome.
Results:
Overall, 161 patients were included in the study and 153 (95%) completed 30-day follow-up. Four (3%) of these patients were misdiagnoses (abscess in the initial computer tomography scan). Total of 14 (9%) patients had pericolic air. Altogether, 140 (87%) patients were treated as outpatients and 4 (3%) of them were admitted to hospital during the follow-up. None of the patients developed complicated diverticulitis or required surgery, but antibiotics were given to 14 (9%, 6 per oral, 8 intravenous) patients 2 days (median) after inclusion.
Limitations:
This study is limited by the lack of comparison group and relatively short follow-up.
Conclusions:
Symptomatic treatment of uncomplicated diverticulitis without antibiotics is safe and effective. |
en |
| dct.language |
en |
|
| ethesis.language.URI |
http://data.hulib.helsinki.fi/id/languages/eng |
|
| ethesis.language |
English |
en |
| ethesis.language |
englanti |
fi |
| ethesis.language |
engelska |
sv |
| ethesis.supervisor |
Sallinen, Ville |
|
| ethesis.thesistype |
pro gradu-avhandlingar |
sv |
| ethesis.thesistype |
pro gradu -tutkielmat |
fi |
| ethesis.thesistype |
master's thesis |
en |
| ethesis.thesistype.URI |
http://data.hulib.helsinki.fi/id/thesistypes/mastersthesis |
|
| dct.identifier.ethesis |
E-thesisID:6e40ac96-08a3-40f3-8958-3ff1cd00caf0 |
|
| ethesis.degreeprogram |
Lääketieteen koulutusohjelma |
fi |
| ethesis.degreeprogram |
Medical curriculum |
en |
| ethesis.degreeprogram |
Medicinska utbildningsprogrammet |
sv |
| ethesis.degreeprogram.URI |
http://data.hulib.helsinki.fi/id/767842ad-05d0-4813-84df-c487f341f1ca |
|
| ethesis-internal.timestamp.reviewStep |
2016-02-17 15:26:59:990 |
|
| dct.identifier.urn |
URN:NBN:fi:hulib-201606092287 |
|
| dc.type.dcmitype |
Text |
|
