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Response guided therapy in hepatitis C : real life treatment results in 786 patients

Show simple item record 2017-01-12T07:53:03Z 2017-01-12T07:53:03Z 2017-01-12
dc.title Response guided therapy in hepatitis C : real life treatment results in 786 patients en
ethesis.discipline Gastroenterology en
ethesis.discipline Gastroenterologia fi
ethesis.discipline Gastroenterologi sv
ethesis.faculty Medicinska fakulteten sv
ethesis.faculty Lääketieteellinen tiedekunta fi
ethesis.faculty Faculty of Medicine en
ethesis.faculty.URI Helsingfors universitet sv University of Helsinki en Helsingin yliopisto fi
dct.creator Bekhtari, Amina
dct.issued 2016
dct.language.ISO639-2 eng
dct.abstract Hepatitis C affects about 160 million individuals worldwide. Chronic HCV infection can lead to various degrees of liver diseases varying from minimal histologic changes to extensive fibrosis and cirrhosis as well as hepatocellular carcinoma. A sustained virologic response (SVR) is the primary goal of HCV treatment as it is associated with decreased risk of morbidity and mortality. The study aimed to assess results of response guided therapy with pegylated interferon α (PegINFα) and ribavirin in HCV infected patients in different genotypes. Overall 611 patients (80%) achieved SVR and 151 patients (20%) did not. We observed the highest SVR rates in genotype 2 and 3 patients although treatment results were quite high in other genotypes as well. In genotypes 2 and 3 the results are excellent with PegINFα + ribavirin, but new drugs are needed in genotype 1, especially in genotype 1b. Based on the treatment response and the low cost, PegINFα + ribavirin combination therapy should still be considered as a cost-effective treatment option for these genotypes. en
dct.subject hepatitis C en
dct.subject chronic en
dct.subject genotype en
dct.subject interferon-alfa en
dct.subject ribavirin en
dct.language en
ethesis.language English en
ethesis.language englanti fi
ethesis.language engelska sv
ethesis.supervisor Färkkilä, Martti
ethesis.supervisor Nieminen, Urpo
ethesis.thesistype pro gradu-avhandlingar sv
ethesis.thesistype pro gradu -tutkielmat fi
ethesis.thesistype master's thesis en
dct.identifier.ethesis E-thesisID:8eeade91-4933-4d96-a3cc-1b5923b73f0d
ethesis.degreeprogram Lääketieteen koulutusohjelma fi
ethesis.degreeprogram Medical curriculum en
ethesis.degreeprogram Medicinska utbildningsprogrammet sv
ethesis-internal.timestamp.reviewStep 2016-11-24 13:05:23:194
dct.identifier.urn URN:NBN:fi:hulib-201701121017
dc.type.dcmitype Text

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