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Cardiopulmonary and sedative effects of anaesthesia produced by climazolam in combination with medetomidine and fentanyl : an experimental study

Show simple item record 2007-02-13T07:37:52Z en 2009-09-01T08:02:59Z und 2018-07-30T07:39:17Z 2007-02-13T07:37:52Z en 2009-09-01T08:02:59Z und 2018-07-30T07:39:17Z 1993
dc.description Vain tiivistelmä. Koko työ lainattavissa Viikin tiedekirjastosta. fi
dc.format.extent 24 bytes en
dc.format.mimetype text/plain en
dc.publisher University of Helsinki en
dc.publisher Helsingin yliopisto fi
dc.publisher Helsingfors universitet sv
dc.title Cardiopulmonary and sedative effects of anaesthesia produced by climazolam in combination with medetomidine and fentanyl : an experimental study en
dc.type Thesis en
ethesis.discipline Surgery en
ethesis.discipline Kirurgia fi
ethesis.discipline Kirurgi sv
ethesis.faculty Faculty of Veterinary Medicine en
ethesis.faculty Veterinärmedicinska fakulteten sv
ethesis.faculty Eläinlääketieteellinen tiedekunta fi
ethesis.faculty.URI Helsingfors universitet sv University of Helsinki en Helsingin yliopisto fi
dct.creator Granholm, Mikael
dct.issued 1993
dct.language.ISO639-2 eng
dct.abstract In veterinary practice intraveneous anaesthesia has numerous advantages. An important advantage is the ease and rapidity of induction. Compared to administration of inhalant anaesthetics, a minimum of apparatus is necessary in administration of intraveneous anaesthetic agents. The possibility of antagonization of certain drugs used as intraveneous anaesthetics increases the safety of anaesthesia. The unpleasant recovery period can also be shortened, which for a busy veterinarian and also the owner can be of great relief. Ideally, a postoperative patient should be conscious, co-operative, calm and free of pain. This will provide better homeostasis of vital functions, allow early diagnosis and treatment of complications and decrease the need for nursing care. The aim of these studies was to analyze the sedative/ analgetic / anaesthetic, cardiovascular and respiratory effects produced by a combination of medetomidine and climazolam at two different dose levels (1.5 mg/kg and 3.0 mg/kg). Climazolam was also combined with fentanyl. Antagonization followed anaesthesia, using atipamezole, nalorphine and a new benzodiazepine antagonist, sarmazenil. 7 laboratory beagles were used inthis experimental study. In combination with medetomidine, climazolam produced smooth anaesthesia and had only small effects on the cardiovascular and respiratory system. Total analgesia was not achived. Intubation was easily performed. The antagonization proved to be fast and complete. When combining climazolam with fentanyl, dose levels were chosen according to previous studies (Erhardt et al., 1986). The anaesthesia was light and short, probably due to the short action of fentanyl. This combination depressed the respiratory system in a much larger scale than the combination of medetomidine and climazolam did. Antagonization was effective. en
dct.subject intraveneous anaesthesia en
dct.subject climazolam en
dct.subject medetomidine en
dct.subject fentanyl en
dct.subject sarmazenil en
dct.subject atipamezole en
dct.subject nalorphine en
dct.language en
ethesis.language English en
ethesis.language englanti fi
ethesis.language engelska sv
dct.identifier.urn URN:NBN:fi-fe201804208000
dc.type.dcmitype Text
dc.identifier.laitoskoodi E9000
dc.format.content abstractOnly

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