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Statistical properties of non-stationary dynamical systems with intermittency

Juho Leppänen

The thesis statistical properties of non-stationary dynamical systems with intermittency concerns two types of non-stationary dynamical systems: sequential compositions of interval maps with a neutral fixed point (Pomeau-Manneville maps) and intermittent quasistatic systems. Both systems are non-uniformly expanding and time-dependent, and (typically) lack invariant measures. The evolutio...

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Disputationen: 14.8.2018

Systems-level neural mechanisms of conscious perception in health and schizophrenia

Jonni Hirvonen

The interplay between senses and actions is one of the most crucial processes that takes place in the brain. The successful course from perception of a stimulus to a meaningful action requires coherent communication between different cortical areas. In humans, these events can be measured non- invasively outside the skull, for example by recording electric or magnetic fields that are pro...

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Disputationen: 15.8.2018

Systemic Interpretation in EU Public Procurement Law

Markus Ukkola

The aim of the dissertation is to assess whether the jurisprudence of the Court has met the standards which secure the coherence and legal certainty and ultimately the acceptability of its rulings. The aim of the study is also to show how, by using systemic arguments, the Court could help to systematize this particular field of EU law and to improve legal certainty. In the study, legal r...

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Disputationen: 16.8.2018

Infrared Behavior of SU(2) Gauge Theory

Viljami Leino

The Standard Model of particle physics provides the most precise description of elementary particle physics. However, the Standard Model is not a complete theory and many theoretical questions still remain unanswered. For example, the exact nature of dark matter, baryogenesis, and neutrino masses remain unknown. Therefore, there is still need for beyond the Standard Model physics. Many i...

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Disputationen: 16.8.2018

Synthesis of Azulene-Based Compounds for Targeting Orexin Receptors

Teppo Leino

Orexin peptides, orexin-A and orexin-B, and orexin receptor 1 and orexin receptor 2 form the orexin signaling system. The most studied part of the orexin system is its key role in sleep-wake regulation, although it is linked also to other physiological functions, such as addiction and nociception. To date, a large number of orexin receptor antagonists have been developed with one, suvore...

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Disputationen: 16.8.2018

Tumor Suppressor Functions of Epithelial Integrity Genes in Breast Cancer

Elsa Isabel de Oliveira Marques

Epithelial integrity defines the well-established positioning and communication of the epithelial cells within the tissue architecture, which is necessary for the epithelium to flawlessly perform its functions. Loss of tissue integrity is a hallmark of practically all advanced solid cancers. Tissue integrity can be lost by altered cell-cell, cell-matrix connections, and/or mislocalizatio...

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Disputationen: 16.8.2018

Multiplex Real-Time PCR in Bovine Mastitis Diagnostics

Heidi Hiitiö

Mastitis is the most common and economically damaging production disease of dairy cows. In the majority of cases it is induced by intramammary infection with a pathogen. Identification of mastitis-causing pathogens enables treatments to be targeted appropriately, avoiding unnecessary antimicrobial treatments, and enabling design of the best possible herd level management protocols. Diagn...

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Disputationen: 17.8.2018

Discovery of OX1 and OX2 orexin receptor ligands

Ainoleena Turku

The main objective of this dissertation was to gain an understanding of orexin receptor activation at the molecular level and apply it in discovery of novel orexin receptor ligands. As non-peptide orexin receptor activators were almost completely unknown at the start of this study, attention was focused on them. To accomplish these goals, I utilized a combination of molecular modelling a...

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Disputationen: 17.8.2018

Divorce, mental health and mortality - A longitudinal register study

Niina Metsä-Simola

Poor mental health is a major public health issue, and across societies, mental health problems and excess mortality are consistently linked to divorce. This thesis examines how poor mental health increases the risk of divorce, how divorce increases the risk of poor mental health and mortality, and what is the role of socio-demographic factors in these associations. It also compares mari...

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Disputationen: 17.8.2018

Let's get cracking- nut allergy diagnostics and peanut oral immunotherapy

Riikka Uotila

Background: Nut allergy diagnostics is complicated, due to asymptomatic sensitization and pollen-induced cross-sensitization. In addition, it is usually a life-long disease, and traditional treatment involves the avoidance of nuts and the administration of emergency medication in accidental exposures. Aims: To study nut allergy diagnostics by evaluating associations with nut- and bi...

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Disputationen: 17.8.2018

ORP2 - A Sterol Sensor Controlling Hepatocellular Bioenergetics and Actin Cytoskeletal Functions

Henriikka Kentala

OSBP-related proteins (ORPs) are lipid binding and transport proteins expressed ubiquitously in eukaryotic cells. ORPs localize at specific organelle interfaces designated membrane contact sites (MCSs). They possess a characteristic ligand-binding domain with specificity for oxysterols, cholesterol and phospholipids. Some ORPs have the capacity to mediate bi-directional transfer and exch...

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Disputationen: 18.8.2018

Ambiguous Bikas - History of the Concept of Development in Nepal 1900-2006

Bandana Gyawali

Development, an ambiguous sociopolitical concept, has become entrenched in the imaginations and vocabulary of the people of Nepal for decades. Its Nepali translation, bikās, is commonly believed to have come into existence with the American Point Four assistance in 1951, followed by a plethora of technical and financial assistance offered by various countries. That development is to be a...

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Disputationen: 23.8.2018

Prefrontal Control of the Tactile Sense

Juha Gogulski

Sense of touch provides information about textures, objects and physical forces acting on our body. Tactile information also guides the motor system by providing feedback of our internally generated movements. The aim of this thesis was to dissect the neural mechanisms underlying different levels of tactile processing in healthy subjects. In the first study of the thesis, the influence o...

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Disputationen: 24.8.2018

Genetics of Breast and Ovarian Cancer Predisposition with a Focus on RAD51C and RAD51D Genes

Liisa Pelttari

Breast and ovarian cancers are common cancers affecting women. Family history of the disease is a major risk factor for both cancers. Even though several susceptibility alleles have been identified, genetic predisposition to breast and ovarian cancer is still largely unexplained. Most of the known risk-genes play a role in DNA repair and especially in homologous recombination repair. RAD...

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Disputationen: 24.8.2018

Novel Approaches for Pluripotent Reprogramming

Jere Veltner

Somatic cells can be reprogrammed to pluripotent state by ectopic expression of a defined set of transcription factors. These induced pluripotent stem cells (iPSC) hold great potential for biomedical applications, such as disease modelling, drug discovery and cell therapies. The derivation of iPSCs is a complex multistep process that can commonly result in inefficient or incomplete conve...

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Disputationen: 24.8.2018

Length calibration of Fourier domain interferometer for particle accelerator quality assurance

Risto Montonen

: Following development of the Large Hadron Collider at CERN (European Laboratory for Particle Physics), a viable option for the future frontiers of particle physics would be the Compact LInear Collider (CLIC). For efficient collider operation, the internal alignment and shape of the particle accelerating structures is crucial, as even micrometer-level misalignments reduce the performan...

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Disputationen: 24.8.2018

Computational studies on chemical ionization and reaction rates of atmospherically relevant oxidized multifunctional compounds

Noora Hyttinen

Following development of the Large Hadron Collider at CERN (European Laboratory for Particle Physics), a viable option for the future frontiers of particle physics would be the Compact LInear Collider (CLIC). For efficient collider operation, the internal alignment and shape of the particle accelerating structures is crucial, as even micrometer-level misalignments reduce the performance ...

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Disputationen: 24.8.2018

Läheisyyden rakentaminen intiimeissä suomalaisissa televisiokeskusteluissa: Nonverbaalisen viestinnän ja tuotannollisten keinojen tarkastelu

Hannele Porkka

Tutkimukseni käsittelee läheisyyden rakentamista intiimeissä suomalaisissa televisiokeskusteluissa. Tarkastelen sitä, miten intiimeihin televisiokeskusteluihin osallistujat rakentavat keskustellessaan sellaista vuorovaikutusta, jossa avaudutaan kertomaan omista henkilökohtaisista asioista, ajatuksista ja tunteista. Tarkastelu kohdistuu erityisesti keskustelijoiden nonverbaaliseen, sanatt...

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Disputationen: 24.8.2018

CLONAL EVOLUTION AND HETEROGENEITY OF CANCER IN THE CONTEXT OF INDIVIDUALIZED MEDICINE

Poojitha Ojamies

Cancer is an evolutionary phenomenon. Development and progression of cancer involves genetic instability and a complex clonal evolution process, which contributes to genetic and phenotypic heterogeneity. Advent of next-generation sequencing technologies has enabled in-depth interrogation of cancer genomes resulting in unraveling of the complexity of genomic heterogeneity and evolution in...

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Disputationen: 24.8.2018

Mediated discourses - ethnic minority media in linguistic and ethnic identity-building and language revitalization: Comparative case studies from Finno- Ugrian minority contexts

Outi Tanczos

The dissertation consists of six peer-reviewed articles and an introduction that presents the background, objectives and results of the study. The thesis investigates the issues of representations of languages and ethnicities and division of power and responsibility in terms of language maintenance. The study takes a comparative perspective and analyzes material from several languages, m...

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Disputationen: 25.8.2018

Pompeian peristyle gardens as a means of socioeconomic representation

Samuli Simelius

This thesis studies the Pompeian peristyle gardens as a means of socioeconomic representation. Gardens featuring at least one colonnade are the main criteria for consideration. The data for the study was collected during extensive field seasons at the site, and by reading the excavation reports and other written descriptions of the gardens. Pompeian studies have previously connected the ...

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Disputationen: 25.8.2018

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AGGREGAATTORIT ÄÄNITTEIDEN DIGITAALISESSA JAKELUSSA Tekijänoikeuslainsäädännön ja verotuksen näkökulmasta

Laine, Annina / 27.04.2017

AGGREGAATTORIT ÄÄNITTEIDEN DIGITAALISESSA JAKELUSSA Tekijänoikeuslainsäädännön ja verotuksen näkökulmasta Laine, Annina Tiivistelmä/Referat – Abstract Internet ja digitaalitekniikan kehitys on mullistanut musiikkialaa merkittävästi ja huomattava osa äänitteistä siirtyy nykyään kuuntelijalle digitaalisessa muodossa. Kuluttajille äänitemarkkinoiden digitalisoituminen merkitsee, että mus...

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Kartellivahingon määrän todistaminen vahingonkorvausoikeudenkäynnissä

Korhonen, Sofie / 27.04.2017

Kartellivahingon määrän todistaminen vahingonkorvausoikeudenkäynnissä Korhonen, Sofie Tiedekunta/Osasto Fakultet/Sektion – Faculty Oikeustieteellinen tiedekunta Laitos/Institution– Department Tekijä/Författare – Author Sofie Korhonen Työn nimi / Arbetets titel – Title Kartellivahingon määrän todistaminen vahingonkorvausoikeudenkäynnissä Oppiaine /Läroämne – Subject Oikeustalo...

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The Patent Economics of Synthetic Biology

Bützow, Alexander / 27.04.2017

The Patent Economics of Synthetic Biology Bützow, Alexander Kyseinen työ tutkii uutta bioteknologian muotoa, synteettistä biologiaa, ja sen suhdetta eurooppalaiseen immateriaalioikeuteen, erityisesti patenttioikeuteen. Tutkielman keskeiset kysymykset koskevat sen selvittämisestä, onko 1) synteettisen biologian keksinnöt systeemisesti soveltumattomia nykyiseen patenttioikeuteen, ja 2...

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Vastuun rajoittaminen asianajotoimeksiantosopimukseen perustuvan vastuunhallinnan keinona

Sotamaa, Rasmus / 27.04.2017

Vastuun rajoittaminen asianajotoimeksiantosopimukseen perustuvan vastuunhallinnan keinona Sotamaa, Rasmus Asianajajan mahdollisuuksiin rajata vastuutaan on perinteisesti suhtauduttu varovaisen torjuvasti niin Suomessa kuin muissakin Pohjoismaissa. Torjuvan suhtautumisen perusteet on usein liitetty asianajotoiminnan erityiseen luonteeseen. Vastuunrajoitukset on nähty erityisesti asianaja...

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