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Development of organotypic liver cell cultures in three-dimensional biomaterial hydrogels

Melina Malinen

New organotypic liver cell cultures are needed to predict the metabolism, excretion, and safety of chemical compounds. Liver cell models are particularly important since the liver largely regulates the ultimate fate of compounds in the body. Approximately 70% of the drugs administered to the body are metabolized or excreted by the liver.

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Väitöstilaisuus: 1.9.2014

Crib-biting in Horses: A Physiological and Genetic Study of Candidate Causative Factors

Karin Hemmann

Crib-biting in horses is an oral stereotypy. A crib-biting horse grasps a fixed object with its incisor teeth, contracts the lower neck muscles to retract the larynx caudally and draws air into the cranial oesophagus while emitting a characteristic grunt. The prevalence of crib-biting varies among equine populations from 1.8% to 15%. Free-ranging horses are not known to crib-bite. The ai...

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Väitöstilaisuus: 5.9.2014

Vestibular function in different otoneurological patients as measured by head tilt and head impulse test

Topi Jutila

The first objective was to evaluate feasibility of head tilt testing and the motorized head impulse test (mHIT) for the quantification of vestibular function and its possible change in different otoneurological patient groups. The second objective was to compare these objective findings with symptoms and other signs for these patients.

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Väitöstilaisuus: 5.9.2014

Article 27 of the Universal Declaration of Human Rights and Internet : A Study Evaluating Role of Prosumers, Authors and Corporations in the Information Society

Olli Vilanka

This dissertation is an article based dissertation evaluating position of prosumers, authors and corporations in the information society especially from the viewpoint of Article 27 of the Universal Declaration of Human Rights (UDHR). Prosumers are understood as private natural persons who use content protected by copyright for non-commercial purposes. Similarly authors are understood, fo...

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Väitöstilaisuus: 5.9.2014

Bayesian Network applications for environmental risk assessment

Annukka Lehikoinen

Environmental risk assessment (ERA) is a process of estimating the probability and consequences of an adverse event due to pressures or changes in environmental conditions resulting from human activities. Its purpose is to search the optimal courses of action under uncertainty when striving for the sustainable use of environment through minimizing the potential losses. As environmental i...

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Väitöstilaisuus: 5.9.2014

Sigrid Undset - A Modern Crusader

Giuseppe Caruso

After leaving her early existential and non-Christian Weltanschauung, the Norwegian writer Sigrid Undset converted to Roman Catholicism and eventually joined the Dominican order as a lay member who played an active role in the promotion of Roman Catholicism in Norway. Although her relationship with the Roman Catholic Church has already been studied by many researchers, issues remain whic...

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Väitöstilaisuus: 5.9.2014

Staphylococcus aureus bacteraemia - Disease progression and prognosis

Erik Forsblom

Introduction. Staphylococcus aureus bacteraemia (bloodstream infection) (SAB) is increasingly common in both community and hospital settings. The presence of deep infection focus is pathognomonic for SAB and deep infection foci should be meticulously searched for and eradicated whenever possible. However, despite effective antistaphylococcal antibiotics, radiological investigations and s...

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Väitöstilaisuus: 6.9.2014

Cell encapsulation in hydrogels for long-term protein delivery and tissue engineering applications

Leena-Stiina Kontturi

Cell therapy is defined as cell transplantation into the patient to treat a certain disease state. Therapies utilizing cells can be divided into two main categories, (1) tissue regeneration or engineering and (2) drug delivery. In tissue engineering, the transplanted cells are used to regenerate the functions of a diseased tissue. In drug delivery, the transplanted cells are used as biol...

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Väitöstilaisuus: 6.9.2014

Fibromyalgia: Background factors and impact on mortality and ability to work

Ritva Markkula

Fibromyalgia: Background factors and impact on mortality and ability to work. The aim was to update the prevalence of fibromyalgia (FM) symptoms, their predictors, and their impact on mortality and ability to work, in an epidemiologically representative cohort. For this we used the older Finnish Twin Cohort, which enabled evaluation of genetic backgrounds, as well. This cohort (original...

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Väitöstilaisuus: 6.9.2014

Virtues of Man, Woman - or Human Being? : An Intellectual Historical Study on the Views of the Later Stoics Seneca theYounger, Musonius Rufus, Epictetus, Hierocles and Marcus Aurelius on the Sameness of the Virtues of Man and Woman

Liisa Tuomela

The aim of this intellectual historical study is to examine the views of the later Stoics Seneca the Younger, Musonius Rufus, Epictetus, Hierocles and Marcus Aurelius on the sameness of the virtues of man and woman, a question which gives a very non-anachronistic perspective on sameness, otherness, equality and inequality in Greek and Roman thinking. Other authors and material discussing...

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Väitöstilaisuus: 10.9.2014

Institutional footprints in the addiction image : A focus-group study with Finnish and French general practitioners and social workers

Michael Egerer

The concept of addiction is increasingly applied in order to understand various problematic behaviours. However, this inclusion remains disputed. The study examines the conceptualisation of addictions by analysing stimulated group discussions of general practitioners and social workers in Finland and France on the topics of alcoholism, pathological gambling and eating disorders. The diss...

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Väitöstilaisuus: 12.9.2014

From music syllabi to teachers' pedagogical thinking: a comparative study of Estonian and Finnish basic school music education

Anu Sepp

This study represents comparative educational research focusing on music syllabi in the National Curricula for basic schools and the pedagogical thinking of music teachers in those schools in Estonia and Finland. The thesis consists of six articles and a summary explaining the background of the research, the research methods, as well as the conclusions and further discussions about the r...

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Väitöstilaisuus: 12.9.2014

Own pace, own space, own face, human, and tool support : Mediators in web-based self-regulation learning

Raija Latva-Karjanmaa

The focus of the study is to identify how mediation supports a web-based course on self-regulation. In the context of education, mediation can be defined as a supporter or promoter of learning. Mediation selects, interprets, and amplifies objects for human learners. The study creates an integrated view of mediators as learning promoters based on Vygotsky s (1978) and Feuerstein s theorie...

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Väitöstilaisuus: 12.9.2014

Endoplasmic Reticulum Stress, Regulation of Autophagy and Ubiquitin-proteasome System in Cellular Models of Huntington s Disease

Alise Hyrskyluoto

Huntington s disease (HD) is a fatal neurodegenerative disease with progressive motor dysfunction, cognitive decline and psychiatric disturbances. HD is caused by a CAG repeat expansion in the huntingtin (IT15) gene, which encodes the huntingtin protein. Mutations in huntingtin cause accumulation of protein aggregates with subsequent cell death and loss of neurons in the striatum and cor...

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Väitöstilaisuus: 12.9.2014

Successional and spatial patterns of bacterial communities in hydrocarbon-contaminated soils and Populus rhizosphere

Shinjini Mukherjee

Ever-increasing urbanization and industrialization have led to contamination of a vast numbers of terrestrial sites with petroleum hydrocarbons. Petroleum hydrocarbon pollution has a deleterious impact on biotic and abiotic properties of ecosystem and can thereby affect some valuable ecosystem services. Microbes have the ability to metabolize various components of these harmful contamina...

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Väitöstilaisuus: 12.9.2014

Molecular Biology and Clinical Occurrence of Emerging Human Polyomaviruses

Mohammadreza Sadeghi

Human polyomaviruses (HPyVs) are known to cause benign initial infection at an early age. They have a high prevalence in the population with frequent incidences of reactivation, and pathologic consequences in those who are elderly or immunosuppressed. Thus far 12 HPyV species have been known. The first two HPyVs, JC virus (JCPyV) and BK virus (BKPyV) were described in 1971. They are asso...

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Väitöstilaisuus: 12.9.2014

Small molecule modulators of tumor suppressor p53 and RNA polymerase I activity: identification, anticancer activity and mechanism of action

Karita Peltonen

The tumor suppressor p53 function is frequently lost in human cancer. This arises through TP53 mutation or through impairment of the wild-type p53 protein function. p53 senses various stress signals and upon activation p53 coordinates a diverse cellular stress response. These responses prevent the accumulation of neoplastic cells and are important for the tumor suppressive function of p5...

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Väitöstilaisuus: 12.9.2014

Deuterium labelling and rearrangement studies of lignans

Monika Pohjoispää

Lignans are naturally occurring compounds, polyphenolic secondary plant and mammalian metabolites. Due to their ubiquitous presence and biological activity, lignans have attracted the interest of scientists from different areas, like nutrition scientists, pharmaceutical researchers and synthetic chemists. The research is very active, and the number of lignan related publications has prol...

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Väitöstilaisuus: 12.9.2014

Yöllä yhdessä : Yökerhot, biletys ja suomalainen sosiaalisuus

Antti Maunu

Social and cultural studies have drawn a picture of Finland as an urbanizing and globalizing society since the 1980's. A main thread in this discussion has dealt with a shift from a collectivist and relatively conformist way of life towards a more individualist one ‒ much like in other Western countries. This is well embodied in Finnish bar and partying studies. According to them, 1980's...

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Väitöstilaisuus: 13.9.2014

Personer med utvecklingsstörning skapar och utövar sitt sociala medborgarskap - spänningsfält kring delaktighet

Ann-Marie Lindqvist

The thesis describes how adults with learning disabilities are experiencing, creating and exercising their social citizenship. It concerns lived citizenship, understood as the meaning citizenship actually has in the persons lives and the ways in which the social and cultural background and material circumstances affect their lives as citizens. It is based on Ruth Lister's understanding o...

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Väitöstilaisuus: 13.9.2014

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Piilevien lajirunsauden ja yhteisökoostumuksen vaihtelu boreaalisissa lähteissä

Teittinen, Anette / 30.08.2014

Piilevien lajirunsauden ja yhteisökoostumuksen vaihtelu boreaalisissa lähteissä Teittinen, Anette; Teittinen, Anette Paikallisten eliöyhteisöjen muodostumiseen vaikuttavat useat erilaisilla mittakaavatasoilla toimivat tekijät. Eliöyhteisöt rakentuvat hierarkkisesti historiallisten, leviämiseen liittyvien ja nykyisten paikallisten abioottisten ja bioottisten tekijöiden ohjaamina. Eristyne...

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Yyterin eolisen aineksen provenanssi

Niemelä, Jussi / 27.08.2014

Yyterin eolisen aineksen provenanssi Niemelä, Jussi Yyterin dyynikentät ovat muodostuneet Porista luoteeseen, selkämereen pistävän Yyterinniemen länsirannalle. Alueen kallioperä on Jotunista Satakunnan hiekkakiveä, joka alueen pintaosissa vaihtelee arkoosisesta areniitista subarkoosiin. Maaperämuodostumat alueella ovat pääosin moreeni- ja harjukerrostumia, jotka luoteesta virrannut manne...

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The effect of 5,6-dimethylbenzimidazole on vitamin B12 synthesis and protein production in Propionibacterium freudenreichii ssp. freudenreichii

Ishchenko, Tatiana / 26.08.2014

The effect of 5,6-dimethylbenzimidazole on vitamin B12 synthesis and protein production in Propionibacterium freudenreichii ssp. freudenreichii Ishchenko, Tatiana Propionibacterium freudenreichii is commonly known as a Swiss-type cheese ripening culture, and is also frequently applied in the industrial production of vitamin B12 (cobalamin). One way to increase vitamin B12 productivity is...

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Attribuution keinoja egyptinarabialaisissa kasvinnimissä

Vesanen, Aino Hanna Mirjami / 28.08.2014

Attribuution keinoja egyptinarabialaisissa kasvinnimissä Vesanen, Aino Hanna Mirjami What kind of extralinguistic considerations people have aimed to express with plant names and which mediums have been used for that purpose in Egyptian Arabic? This thesis aims to answer that question with regard to the local dialects spoken in Beni Suef, Fayyūm and Tanta countryside. The perspective h...

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