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TGF-β family signaling in the regulation of cell plasticity in lung cells and mesothelioma

Jenni Tamminen

The aim of this thesis was to extend the understanding of molecular mechanisms of asbestos exposure related diseases asbestosis (lung fibrosis), lung cancer and mesothelioma. Epithelial-to-mesenchymal transition (EMT) is implicated in fibrosis and in cancer, both asbestos induced diseases. The first of the three studies investigated whether asbestos fibers induced EMT. In the next two st...

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Väitöstilaisuus: 19.12.2014

Inverse boundary problems involving the magnetic Schrödinger operator

Valter Pohjola

This thesis deals with various aspects of the inverse boundary value problem for the magnetic Schrödinger operator. The first paper extends earlier uniqueness results to the case where the domain is a half space. The two main features of this problem is that the domain is not a bounded set and that the DN-maps are known only on parts of the boundary. The results in this paper extend know...

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Väitöstilaisuus: 19.12.2014

Joseph Sittler and Early Ecotheology

Panu Pihkala

This study analyzes early twentieth-century ecotheology about which it provides a great deal of new information. The focal point is the work of Joseph Sittler (1904 1987), an American Lutheran and ecumenical theologian. Through the use of systematic analysis and historical methods, Sittler s thought is placed in context in relation to other early ecotheology and environmentalism. Many st...

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Väitöstilaisuus: 19.12.2014

Prognostic Models in Traumatic Brain Injury

Rahul Raj

Background: Prognostic models are important tools for heterogeneity adjustment in traumatic brain injury (TBI). Prognoses after TBI have been particularly challenging to predict, with limited availability of robust prognostic models. TBI patients are by definition trauma patients, and often treated in the intensive care unit (ICU). Several prognostic models for ICU and trauma patients ha...

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Väitöstilaisuus: 19.12.2014

Kirjoitelma ja tekijän ääni : Kehystämisen yhdyslauseet suomenkielisen ylioppilasaineen dialogisuuden hallinnassa

Riitta Juvonen

The study examines framing (or projecting) clause complexes in Finnish-language matriculation essays from the point of view of the intersubjective positioning of the writer. The clause complexes investigated comprise of a matrix clause and its complement, mainly an että that or a kuinka/miten how clause. The starting point for the analysis is the assumption that the matrix clause express...

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Väitöstilaisuus: 19.12.2014

Oral and nutritional problems among residents in assisted living facilities

Riitta Saarela

This study formed part of a developmental project in the Helsinki Metropolitan Area of Finland during 2003 2011 that aimed to develop nutritional care in long-term care facilities. The aim of this study was to assess tooth brushing/denture cleaning habits, dentition, chewing problems, and swallowing difficulties and their associations with nutritional status and eating habits. Furthermor...

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Väitöstilaisuus: 19.12.2014

Systematizing morphology: a total evidence approach to ditrysian phylogenetics (Lepidoptera)

Maria Heikkilä

Lepidoptera (butterflies and moths) are one of the most diverse and species-rich groups of organisms. Currently, the number of described species is close to 160.000, but it is estimated that the true number of species could be as high as half a million. Nearly 99% of all Lepidoptera belong to the more advanced subclade Ditrysia. The focus of this thesis is the evolutionary history of the...

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Väitöstilaisuus: 19.12.2014

Role of 3'UTR in the regulation of neurotrophic factors BDNF and GDNF

Anmol Kumar

Neurotrophic factors such as brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) are a family of proteins which play an important role inside and outside central nervous system. While precise regulation of BDNF and GDNF levels in time and space in an organism is crucial in determining the biological outcome, mechanisms involved in controlling t...

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Väitöstilaisuus: 19.12.2014

Structural studies of O-acetylglucuronoxylans and their modifications in plant cell walls

Sun-Li Chong

O-acetylglucuronoxylans (AcGX) are the major hemicelluloses found in the secondary cell wall of dicotyledon species. The backbone is formed by β(1→4)-linked xylopyranosyl (Xylp) residues, which are substituted by α(1→2)-linked (4-O-methyl)glucopyranosyluronic acid ((Me)GlcpA). The AcGX are also highly acetylated on the 2-O or 3-O; or both positions of Xylp units. Notably, acetylation pat...

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Väitöstilaisuus: 19.12.2014

Activation of innate immune response in human macrophages by Herpes simplex virus-1 and crystallized monosodium urate

Juho Miettinen

Innate immunity provides the first line of defence against invading pathogens, and can also be activated by endogenous danger signals released upon tissue damage or injury. Macrophages play an important role in innate immunity. They perform the immune surveillance of their immediate surroundings seeking out tissue damage and/or invading pathogens via pattern recognition receptors. Macrop...

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Väitöstilaisuus: 19.12.2014

Evolution in salt: Genomic and structural approaches to halophilic archaea and their viruses

Salla Jaakkola

Extremely saline environments include salt lakes, evaporation ponds, and terrestrial environments, such as salt deserts and underground halite deposits. They are inhabited by halophilic microbes that require salt for living. Cell densities in hypersaline waters can be as high as 107-108 cfu/ml, and most of the cells are archaeal. The number of viruses can be ten times higher than that of...

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Väitöstilaisuus: 19.12.2014

Studies on Earnings Dynamics and Uncertainty in Return to Education

Otto Kässi

This thesis studies earnings differences and their dynamics empirically. It consists of an introductory chapter and three independent research papers. All of the three papers are done using Finnish registry data. Chapter two studies the evolution of income inequality from the end of 1980s until the year 2007. I present a statistical decomposition method, which is used to decompose earnin...

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Väitöstilaisuus: 19.12.2014

Physical activity, nutrition and stress response in young adults born preterm − determinants of health and disease : The Helsinki Study of Very Low Birth Weight Adults

Nina Kaseva

Advancements in neonatal care are resulting in increasing numbers of adult survivors after preterm birth at very low birth weight (VLBW, ≤ 1500 g). VLBW is associated with risk factors of non-communicable diseases, e.g. cardiovascular disease, osteoporosis and diabetes. We investigated mechanisms underlying the effects of preterm birth on later health in VLBW adults, with a focus on 1) p...

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Väitöstilaisuus: 19.12.2014

RARE GENOMIC DELETIONS UNDERLYING SCHIZOPHRENIA AND RELATED NEURODEVELOPMENTAL DISORDERS

Olli Pietiläinen

Severe mental disorders including schizophrenia often segregate within the same families. Twin and family studies suggest that this co-occurrence is largely genetic, which implies that the different mental disorders have a shared genetic background. Some symptomatic features, such as cognitive impairment also manifest to a variable degree in the majority of severe mental disorders. Cogni...

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Väitöstilaisuus: 19.12.2014

Väkivaltatyön käytännöt, sukupuoli ja toimijuus : Etnografinen tutkimus lähisuhdeväkivaltaa kokeneiden naisten auttamistyöstä Venäjällä

Maija Jäppinen

Early in the post-Soviet years, domestic violence emerged as a social problem in Russia. In contemporary Russia, non-governmental organisations (NGOs) opened the first women s crisis centres, followed by the set up of public crisis departments inside social service centres. This study examines the work with survivors of violence carried out in such centres. Analysis of the assistance pra...

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Väitöstilaisuus: 9.1.2015

Sequence variability of virulence genes and stress responses in Yersinia pseudotuberculosis

Eveliina Palonen

Yersinia pseudotuberculosis infections derive from ingestion of contaminated food or water. Typical symptoms of yersiniosis are fever and abdominal pain resulting from mesenteric lymphadenitis, and immunological sequelae are possible. The pathogen has recently caused several epidemics in Finland through fresh produce. However, the slow growth rate and poor competition of Y. pseudotubercu...

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Väitöstilaisuus: 9.1.2015

Hybrid Materials: Surface Modification of Different Silica Surfaces and Synthesis of Multiresponsive Hybrid Polymers

Mikko Karesoja

In this study several inorganic-organic hybrids and multiresponsive hybrid polymers were prepared and characterised in detail. Especially the focus has been on stimuli responsive materials but also on nanocomposites based on modified montmorillonite clay. Furthermore thin SiO2-capillaries were modified for electrophoretic separations. In all cases different controlled radical polymerisat...

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Väitöstilaisuus: 9.1.2015

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Storspiggens mesopredatoriska inverkan på trådalgsbältet i Östersjön

Johanson, Anna / 19.12.2014

Storspiggens mesopredatoriska inverkan på trådalgsbältet i Östersjön Johanson, Anna Havsekosystemen runt om i världen lider av antropogen inverkan såsom näringsutsläpp och utfiske. Speciellt utfiske av högre trofiska nivåer dvs. stora rovfiskar, anses ha ändrat dynamiken i flera näringsvävar. Ändringarna har lett till kraftiga trofiska kaskader som ökat eller minskat primärproduktionen s...

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Lihasikojen hyvinvoinnin yhteys tuotannon taloudelliseen tulokseen

Sampolahti, Heikki / 18.12.2014

Lihasikojen hyvinvoinnin yhteys tuotannon taloudelliseen tulokseen Sampolahti, Heikki Kotieläintalouden eettisyys ja eläinten hyvinvointi on ollut vahvasti esillä yhteiskunnallisessa kes-kustelussa. Tässä tutkimuksessa tarkasteltiin lihasikojen hyvinvoinnin ja tuotannon taloudellisen tuloksen välistä yhteyttä. Tutkimus koostuu kahdesta aineistosta: Welfare Quality-menetelmällä saadusta h...

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Distribution of melanin binding drugs – A kinetic study with pigmented and albino rats using SPECT/CT imaging method

Nurmi, Satu / 16.12.2014

Distribution of melanin binding drugs – A kinetic study with pigmented and albino rats using SPECT/CT imaging method Nurmi, Satu Many drugs are known to bind to melanin, a complex pigment polymer found in several human tissues. Melanin can act as a natural depot by prolonging the effect of the drug and reducing its toxicity. Since it is highly concentrated in the posterior part of the ey...

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Den deltagande demokratins ideal och praktik : En fallstudie i deltagande budgetering vid Helsingfors Ungdomscentral

Boldt, Georg / 17.12.2014

Den deltagande demokratins ideal och praktik : En fallstudie i deltagande budgetering vid Helsingfors Ungdomscentral Boldt, Georg Denna avhandling behandlar medborgardelaktighet i offentliga beslutsprocesser och framförallt de faktorer som måste uppfyllas för att deltagandet skall upplevas som meningsfullt. Avhandlingen är utförd som en fallstudie i Helsingfors stads Ungdomscentrals pil...

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