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Numerical and analytical investigations of physics beyond the Standard Model

Sara Tähtinen

This thesis consists of three separate research papers, and an introductory overview concentrating on the physics relevant for these subjects. In the first paper we use classical, real-time simulations to study gravitational wave production in the early Universe. The second paper focuses on extended Technicolor corrections to the Higgs mass. The third paper uses lattice gauge field theor...

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Väitöstilaisuus: 16.11.2018

Genetic Reconstruction of Ancient Northern European Cattle and Sheep Populations

Marianna Niemi

Ancient DNA holds tremendous potential to answer multidisciplinary research covering topics in evolution and origins of species, their population genetics and migration. The data produced can also be used to date events in the history of particular species. Here, for the first time, these aspects are studied by analysing ancient and contemporary DNA samples from cattle and sheep from the...

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Väitöstilaisuus: 16.11.2018

Understanding Ancestral Land as a Definer of Indigeneity : The Evidence of Toponyms from the Semai and Tl'azt'en Cultural Contexts

Karen Heikkilä

Investigated in this thesis is an important but largely ignored component of indigenous oral traditions: place-names. Building on toponymic research conducted with Tl’azt’en Nation, the thesis retains a deeper focus on Semai Orang Asli toponyms and place narratives. Argumentation for the importance of documenting indigenous toponyms for reasons of cultural posterity, particularly the use...

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Väitöstilaisuus: 16.11.2018

Vitamin D and extraskeletal effects in children : Studies on infections, allergies and inflammation

Jenni Rosendahl

Vitamin D is essential for normal childhood growth and bone development. For almost 90 years, vitamin D supplementation has been recommended for children in Finland. Besides its essential effects on bone and mineral metabolism, vitamin D has several extraskeletal actions and is an important modulator of the immune system. Vitamin D status is defined by serum 25-hydroxyvitamin D concentra...

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Väitöstilaisuus: 16.11.2018

Analysis of gene mutations in exhaled breath condensate from healthy and lung cancer individuals and profiling of mutations and gut microbiota in stools from patients with gastrointestinal neoplasms

Omar Youssef

Lung and gastrointestinal (GIT) cancers are two types of malignancies in which early diagnosis has a significant impact on prognosis and better survival rate. Exhaled breath condensate (EBC) from lung cancer patients and stool from patients with GIT tumors can represent non-invasive sources for diagnosis of malignancy at an early stage. These materials contain DNA from cells exfoliated f...

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Väitöstilaisuus: 16.11.2018

Pulseless Electrical Activity : Treatment during and after cardiopulmonary resuscitation and patient survival

Sini Saarinen

Aims: The aim was to investigate the treatment of cardiac arrest (CA) patients with pulseless electrical activity (PEA) during and after cardiopulmonary resuscitation (CPR). Material and Methods: Treatment of the underlying cause of PEA during CPR was evaluated among in-hospital cardiac arrest (IHCA) patients. Factors determining the intensity of hospital care, treatment methods and surv...

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Väitöstilaisuus: 16.11.2018

Development of Mass Spectrometric Methods for Analysis of Anabolic Androgenic Steroids

Laura Hintikka

Anabolic-androgenic steroids (AAS) are synthetic compounds that are structurally related to testosterone. AAS are an important class of drugs that are commonly abused in sport and are classified as prohibited substances according to the World Anti-Doping Agency (WADA). AAS are metabolized extensively in the human body and excreted to urine mostly as glucuronides or sulphates. These conju...

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Väitöstilaisuus: 16.11.2018

Pohjoinen polku kapitalismin ympäristöhistoriaan : Tervakapitalismi, yhteisvauraus ja sosioekologinen mullistus 1800-luvun Kainuussa

Tero Toivanen

This doctoral dissertation analyses the social and ecological changes in nineteenth-century northern Finland in the context of capitalist world-system. The object of the study is the ‘socio-ecological turmoil in Kainuu’, or the transformation in the assembly of sources of livelihood, social relations and conceptions of nature in the region known as Kainuu. The study researches why and ho...

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Väitöstilaisuus: 16.11.2018

Moniääninen ruokaympäristö – ruokakasvatuksen mahdollisuudet nuorisotaloilla

Eila Kauppinen

Eating habits are linked to the growth and development of children and young people as well as wellbeing in childhood and adulthood. The development of positive, sustainable eating habits can be promoted with the help of food education. Food education is especially important in modern society, as a wide range of food-related information is spread quickly through the social media channels...

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Väitöstilaisuus: 16.11.2018

Role of oscillations in visual perception: attention and working memory

Santeri Rouhinen

People have large differences in their visual attentional and working memory (WM) abilities. Both attention and WM are thought to comprise of representation of sensory information and its attentional / executive control. A common finding is that people’s ability to attend to or to memorize several items concurrently ranges from 2 to 4 items. How attention and working memory functions ari...

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Väitöstilaisuus: 19.11.2018

Chemical behaviour of bentonite in the near field of the KBS-3V concept

Aku Itälä

In Finland the spent nuclear fuel final repository of Posiva Oy is based on the Swedish KBS-3V multi-barrier concept. In this concept, the spent fuel rods are placed inside cast iron inserts surrounded by a gastight copper canister. The canister is placed in a vertical borehole and surrounded by bentonite clay rings at a depth of at least 400m in an underground bedrock facility at Olkilu...

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Väitöstilaisuus: 20.11.2018

Impacts of weather and climate on mortality and self-harm in Finland

Reija Ruuhela

Human beings are able to adapt to their climatic normal conditions, but weather extremes may pose a substantial health risks. The aims of this dissertation were to model the dependence of all-cause mortality on thermal conditions in Finland, and to assess changes in the relationship over the decades and regional differences in the relationships between hospital districts. Another aim was...

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Väitöstilaisuus: 21.11.2018

Telecouplings in a globalizing world: linking food consumption to outsourced resource use and displaced environmental impacts

Vilma Sandström

Globalization has increased the interconnections between world regions. The distal socio-economic and environmental interactions, feedbacks and outcomes between land systems are called telecouplings. The increase in telecouplings is also true with agricultural production and food systems as food trade has intensified in the past decades. This change has contributed to many positive aspec...

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Väitöstilaisuus: 21.11.2018

Thermodynamics and dynamics of polar ice sheets, glaciers and ice shelves under changing climate

Ilona Välisuo

Polar ice sheets, glaciers, and ice shelves, referred to as land ice in this document, are under transition in the changing climate. Observations show that glaciers have retreated and melt water discharge from land ice has increased together with the warming climate. Decreasing volume of land ice is reflected to the whole Earth system via changes in surface radiation balance, sea level r...

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Väitöstilaisuus: 23.11.2018

Deep Brain Stimulation of the Subthalamic Nucleus, Effect on Parkinsonian Motor Symptoms and Experimental Effects with CDNF

Antti Huotarinen

Parkinson’s disease (PD) is the second most common neurodegenerative disorder, affecting about 1% of people over 65. The cardinal motor symptoms of PD are mostly due to reduced dopaminergic signaling in the nigrostriatal system and can be effectively treated with dopaminergic medication. However, the most effective treatment, levodopa (L-DOPA), leads to dyskinesias or motor fluctuations....

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Väitöstilaisuus: 23.11.2018

TRANSITIONS TO ADULTHOOD AMONG FINNISH YOUNG PEOPLE - A mixed-methods study based on longitudinal register data and interviews with street-level professionals

Jaakko Harkko

Background: While the majority of Finnish young adults make transitions to adulthood rather uniformly and successfully, many individuals face exclusion from employment or low pay and job inequalities associated with insecure labour markets. The general aim of this study is to examine the transitions to adulthood of Finnish young people. The research describes how the processes of transit...

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Väitöstilaisuus: 23.11.2018

Antifungal and Antileukemic Compounds from Cyanobacteria: Bioactivity, Biosynthesis, and Mechanism of Action

Anu Humisto

Nature is a treasury of bioactive natural products that are developed into pharmaceuticals, cosmetics and other industrial applications. Natural products have an impact on all of us, for instance, in the form of antibiotics. Most of the drugs sold today are natural products or their derivatives. However, the need for new natural products has not decreased but is rather increasing. The in...

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Väitöstilaisuus: 23.11.2018

Metal(IV) Phosphate Based Functional Materials for Selectively Harvesting Rare-Earth Elements from Bauxite Residue

Wenzhong Zhang

Inorganic metal(IV) phosphates with adjustable structural features, strong acid resistance and selective ion-exchange capabilities are an ideal class of materials to be applied in solid-liquid metal separation processes. The surface hydroxyl groups with ion-exchange capability also grant the metal(IV) phosphates with vast possibilities for further functionalisation and hybridisation.

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Väitöstilaisuus: 23.11.2018

Effects of dietary management on the energy metabolism of periparturient dairy cows: regulation of lipidome and transcriptome

Nanbing Qin

High-producing dairy cows suffer from metabolic stress, particularly during the periparturient period. The high nutrient demand of milk production leaves the animals susceptible to various metabolic diseases after calving. Improving the health and welfare of high-producing dairy cows has been a long-term goal of dairy research and it is critical for the sustainability of the dairy indust...

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Väitöstilaisuus: 23.11.2018

Exercise and Falls among Frail Older People -Special Focus on People with Dementia

Niko Perttilä

Background: The term frailty is used to describe older persons who are at increased risk of adverse health outcomes. Various measures have been investigated but Fried’s criteria are used most often. However, there is still a lack of consensus on the definition of frailty. Simpler measures based on postal questionnaires have also been investigated in the assessment of frailty. Different m...

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Väitöstilaisuus: 23.11.2018

Revival and regeneration of Indigenous knowledge in intercultural bilingual teacher education - A study in the Ecuadorian Amazonia

Tuija Veintie

This doctoral dissertation examines how Indigenous knowledge is recognized and incorporated into a teacher education programme targeted at Amazonian Indigenous Shuar, Achuar and Kichwa students. It is based on an ethnographic field study in an intercultural bilingual teacher education (IBTE) institute in the Amazonian region of Ecuador. This study leans on theory and concepts deriving fr...

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Väitöstilaisuus: 23.11.2018

Diet, diabetes, and prevention of cognitive decline - Focus on lifestyle intervention

Jenni Lehtisalo

Late-life cognitive impairment and dementia are more common among individuals with type 2 diabetes, and these disorders also share risk factors, such as obesity, as well as protective factors, such as healthy diet. Diabetes prevention could improve cognitive performance later in life, and improvement in diet may potentially prevent cognitive impairment through several pathways. This stud...

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Väitöstilaisuus: 23.11.2018

Dekadens och queer i Hagar Olssons tidiga prosa

Eva Kuhlefelt

I min avhandling analyserar jag dekadensrelaterade och queert inspirerade motiv i fyra romaner av den finländska modernistpionjären Hagar Olsson (1893-1978): Lars Thorman och döden (1916), På Kanaanexpressen (1929), Det blåser upp till storm (1930) och Chitambo (1933). Syftet är att vidareutveckla de frågeställningar som den feministiskt orienterade Olssonforskningen introducerat och där...

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Väitöstilaisuus: 23.11.2018

Evaluation of epaxial muscle structure in dogs with spinal disease

Anna Boström

Epaxial muscle atrophy, decreased cross-sectional area (CSA) and increased fat infiltration has been found in dogs with spinal pathology. However, methods to quantify muscle structure have not been validated, and breed differences in the epaxial muscle architecture of dogs have not been considered in relation to spinal pathology. We aimed to validate a method to quantify epaxial muscle s...

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Väitöstilaisuus: 23.11.2018

Placental abruption - Studies on maternal and offspring long-term morbidity and mortality

Outi Riihimäki

Placental abruption, defined as a premature separation of the placenta from the uterine wall before delivery, is a serious obstetric complication with many potential adverse outcomes for both mother and fetus. The etiology of abruption is not fully understood. Smoking, previous abruption and hypertensive disorders are significant factors in the development of the condition. Children born...

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Väitöstilaisuus: 23.11.2018

ALTERATIONS AND IMPACT OF THROMBIN GENERATION AND CLOT FORMATION IN SOLVENT/DETERGENT PLASMA, FXIII DEFICIENCY AND LYSINURIC PROTEIN INTOLERANCE

Hanna Pitkänen

Hemostasis is a crucial biological process, in which thrombin generation (TG) and formation of fibrin network are key elements. Equally important is the capability to dissolve the blood clots through fibrinolysis to repair blood flow. This thesis seeks to recognize factors influencing TG, fibrin formation and fibrinolysis related to solvent/detergent (S/D) plasma, congenital factor XIII ...

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Väitöstilaisuus: 23.11.2018

Chronic physical diseases and depressive symptoms: Insight into the association of long QT syndrome and type 2 diabetes with depressive symptoms

Karolina Wesolowska

Individuals diagnosed with chronic physical diseases, such as coronary artery disease (i.e., a cardiac condition being a risk factor for ventricular arrhythmias) and type 2 diabetes (T2D; i.e., a metabolic condition characterized by high glucose levels), are at risk of developing mental health problems. In parallel, people with mental health problems, including depressive symptoms, have ...

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Väitöstilaisuus: 23.11.2018

Modelling circulation dynamics in the northern Baltic Sea

Antti Westerlund

Circulation and surface layer dynamics are of significant importance, for example, when considering how hazardous substances or nutrients are transported in the sea. The earliest studies mapping circulation patterns in the northern Baltic Sea were done before the Second World War and were based on lightship observations. Although the number of available observation points was low, these ...

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Väitöstilaisuus: 23.11.2018

Neurotoxin regulation and the temperature stress response in Clostridium botulinum

Gerald Mascher

Clostridium botulinum is a dangerous foodborne pathogen that forms highly resistant endospores and the extremely potent botulinum neurotoxin. Whereas endospores enable the survival and transmission of the organism in many harsh environments, the botulinum neurotoxin blocks neurotransmission and causes the severe and potentially lethal disease botulism in humans and animals. Both traits p...

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Väitöstilaisuus: 23.11.2018

Discourse Networks and Justifications of Climate Change Policy - News Media Debates in Canada, the United States, Finland, France, Brazil and India

Anna Kukkonen

This dissertation examines the role of discourse networks—defined as networks of policy actors who are related through shared political discourse—in climate change policy in Canada, the US, Finland, France, Brazil and India. The research material consists of statements from policy actors in over 2700 articles from 14 newspapers. My approach is guided by recent developments in the study o...

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Väitöstilaisuus: 24.11.2018

Anchoring craft - The object as an intercultural and intertemporal unifying factor

Liubov Vetoshkina

This study focuses on the potential of objects in craftwork activities, specifically in wooden boat building. The monograph addresses two polar trends in scientific conceptualisations of craftwork: eliminating objects from skill-focused analyses of crafts and eliminating the cultural and historical potential of objects in craftwork. This study aims to move beyond general interpretations ...

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Väitöstilaisuus: 24.11.2018

Long-term outcome of bipolar I and II disorders

Sanna Pallaskorpi

The Jorvi Bipolar Study (JoBS) is a collaborative bipolar research project between the Unit of Mental Health of the National Institute for Health and Welfare (former Department of Mental Health and Alcohol Research of the National Public Health Institute), Helsinki and the Department of Psychiatry, Jorvi Hospital (HUCH), Espoo, Finland. JoBS is a prospective, naturalistic cohort study of...

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Väitöstilaisuus: 24.11.2018

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AGGREGAATTORIT ÄÄNITTEIDEN DIGITAALISESSA JAKELUSSA Tekijänoikeuslainsäädännön ja verotuksen näkökulmasta

Laine, Annina / 27.04.2017

AGGREGAATTORIT ÄÄNITTEIDEN DIGITAALISESSA JAKELUSSA Tekijänoikeuslainsäädännön ja verotuksen näkökulmasta Laine, Annina Tiivistelmä/Referat – Abstract Internet ja digitaalitekniikan kehitys on mullistanut musiikkialaa merkittävästi ja huomattava osa äänitteistä siirtyy nykyään kuuntelijalle digitaalisessa muodossa. Kuluttajille äänitemarkkinoiden digitalisoituminen merkitsee, että mus...

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Kartellivahingon määrän todistaminen vahingonkorvausoikeudenkäynnissä

Korhonen, Sofie / 27.04.2017

Kartellivahingon määrän todistaminen vahingonkorvausoikeudenkäynnissä Korhonen, Sofie Tiedekunta/Osasto Fakultet/Sektion – Faculty Oikeustieteellinen tiedekunta Laitos/Institution– Department Tekijä/Författare – Author Sofie Korhonen Työn nimi / Arbetets titel – Title Kartellivahingon määrän todistaminen vahingonkorvausoikeudenkäynnissä Oppiaine /Läroämne – Subject Oikeustalo...

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The Patent Economics of Synthetic Biology

Bützow, Alexander / 27.04.2017

The Patent Economics of Synthetic Biology Bützow, Alexander Kyseinen työ tutkii uutta bioteknologian muotoa, synteettistä biologiaa, ja sen suhdetta eurooppalaiseen immateriaalioikeuteen, erityisesti patenttioikeuteen. Tutkielman keskeiset kysymykset koskevat sen selvittämisestä, onko 1) synteettisen biologian keksinnöt systeemisesti soveltumattomia nykyiseen patenttioikeuteen, ja 2...

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Vastuun rajoittaminen asianajotoimeksiantosopimukseen perustuvan vastuunhallinnan keinona

Sotamaa, Rasmus / 27.04.2017

Vastuun rajoittaminen asianajotoimeksiantosopimukseen perustuvan vastuunhallinnan keinona Sotamaa, Rasmus Asianajajan mahdollisuuksiin rajata vastuutaan on perinteisesti suhtauduttu varovaisen torjuvasti niin Suomessa kuin muissakin Pohjoismaissa. Torjuvan suhtautumisen perusteet on usein liitetty asianajotoiminnan erityiseen luonteeseen. Vastuunrajoitukset on nähty erityisesti asianaja...

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