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Mathematical modeling of treatment resistance in cancer

Emilia Kozlowska

Cancer is one of the world’s most lethal diseases. Although our understanding of this disease is expanding continuously, treatments for many types of cancers are still ineffective. The main reason for the high mortality of cancer patients is resistant to therapy. Since resistance to therapy is a complex and dynamical process, an interdisciplinary approach is necessary to understand it. T...

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Väitöstilaisuus: 24.5.2019

Human listeriosis : Grouping of human Listeria monocytogenes isolates with PFGE and AscI restriction enzyme

Gloria Lopez Valladares

Isolates of Listeria monocytogenes (N=932) collected from human cases of invasive listeriosis in Sweden between 1958 and 2010 were serotyped and characterised with pulsed-field gelelectrophoresis (PFGE) and AscI restriction enzyme. The genotype diversity of L. monocytogenes isolates was investigated and related to genotypic results from epidemiological information on human infection, in ...

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Väitöstilaisuus: 24.5.2019

Volatile organic compound fluxes from northern forest soils

Mari Mäki

Emissions of biogenic volatile organic compounds (BVOCs) cool down the global climate via their impacts on aerosol and cloud formation. Climate change will likely have a major impact on BVOC fluxes from the biosphere, including soils, due to temperature-driven plant biosynthesis of volatile organic compounds (VOCs), compound volatility and microbial activity. Soils are a poorly quantifie...

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Väitöstilaisuus: 24.5.2019

Preparing for the unprecedented – Moving towards quantitative understanding of oil spill impacts on Arctic marine biota

Maisa Nevalainen

The risk of a major oil spill in the Arctic has become a matter of global concern, since climate change is extending the ice-free period and bringing more shipping to the area. The Arctic is already under great pressure from climate change, and an oil spill in this unique and sensitive environment could be a catastrophe for its biota. Fortunately, no major oil spill has happened in the t...

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Väitöstilaisuus: 24.5.2019

Healthcare Utilization in Rheumatic Diseases

Nina Mars

Rheumatoid arthritis (RA), psoriatic arthritis (PsA), juvenile idiopathic arthritis (JIA) and axial spondyloarthritis (AxSpA; including ankylosing spondylitis) are inflammatory rheumatic diseases contributing to a substantial burden on both the patient and society. During the past couple of decades, active treatment strategies and pharmacological advancements have altered their cost stru...

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Väitöstilaisuus: 24.5.2019

Data limited fisheries: Incorporating expert knowledge into stock assessment

Anna Chrysafi

Stock assessment is a critical step in fisheries management, since it directly estimates reference points that help determine whether a population’s size is acceptable and subsequently, to set harvest levels. Therefore, many international agreements require that all exploited aquatic populations are assessed quantitatively. However, for the majority of the worlds’ harvested fish stocks, ...

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Väitöstilaisuus: 28.5.2019

Language identification in texts

Tommi Jauhiainen

This work investigates the task of identifying the language of digitally encoded text. Automatic methods for language identification have been developed since the 1960s. During the years, the significance of language identification as an important preprocessing element has grown at the same time as other natural language processing systems have become mainstream in day-to-day application...

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Väitöstilaisuus: 28.5.2019

A Study in Authenticity : Admissible Concealed Indicators of Authority and Other Features of Forgeries—A Case Study on Clement of Alexandria, Letter to Theodore, and the Longer Gospel of Mark

Timo Paananen

A standard approach in historically minded disciplines to documents and other artefacts that have become suspect is to concentrate on their dissimilarities with known genuine artefacts. While such an approach works reasonably well with relatively poor forgeries, more skilfully done counterfeits have tended to divide expert opinions, demanding protracted scholarly attention. As there has ...

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Väitöstilaisuus: 29.5.2019

Formation of hydrothermal REE-phosphate deposits

Stefan S. Andersson

Rare earth elements (REE) are important metals used in green and low-carbon energy and information technologies and are widely used for geological petrogenetic studies. It is becoming increasingly evident that the REE can be mobile in certain hydrothermal fluids and even form hydrothermal REE deposits. This study focuses on the formation of hydrothermal REE deposits rich in the REE-phosp...

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Väitöstilaisuus: 29.5.2019

A pragmatist inquiry into the art of living – Seeking reasonable and life-enhancing values within the fallible human condition

Frank Martela

We are already engaged in a stream of experiencing in which we strive to navigate our way toward what we value. Taking this depiction of the human condition as the starting point, in this dissertation my aim is to embark on an inquiry that aims to identify a few reasonable tools of thinking that may help humans live more reflective and meaningful lives. The project builds strongly on ...

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Väitöstilaisuus: 29.5.2019

Variation in the Use and Norms of English Verb Forms: A Study of Finnish University Students and Teachers

Satu von Boehm

This study focuses on variation in Finnish university students’ use of English verb forms and teachers’ assessment of such use. The goal of the study was to identify the nature and extent of variation in both students’ responses and teachers’ assessment of these responses. The study demonstrates that there is extensive variation in both students’ use of English verb forms and in teachers...

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Väitöstilaisuus: 29.5.2019

Tetralogy of Fallot in Finland

Pekka Ylitalo

Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart defect. Postoperative patients with TOF are mostly compromised by chronic pulmonary regurgitation and chronic right ventricular volume load. These patients suffer from impaired exercise capacity and have an increased risk of sudden cardiac death (SCD) and heart failure. This thesis investigates the long-term outcome o...

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Väitöstilaisuus: 29.5.2019

Computational investigation of cancer genomes

Amjad Alkodsi

Cancer is a leading cause of death worldwide, and its incidence is increasing due to modern lifestyle that prolonged human life. All cancers originate from a single cell that had acquired genetic aberrations enabling uncontrolled proliferation. Each cancer is unique in its aberrant genetic makeup, which defines, to large extent, its biology, aggressiveness, and vulnerabilities to differe...

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Väitöstilaisuus: 29.5.2019

Arviointi, tieto ja hallinta : Peruskoulun paikallisen arvioinnin genealogia

Hannele Pitkänen

Tutkimuksessa analysoin perusopetuksen paikallisen arvioinnin – koulujen ja kuntien itsearvioinnin – muotoutumista suomalaisessa perusopetuksen arviointidiskurssissa. Genealogian tapaan tutkimus on lähtenyt nykyisestä ymmärryksestä – ymmärryksestä, jonka mukaisesti arviointi on välttämätön ja luonnollinen osa koulujen ja koulutuksen järjestäjien toimintaa sekä viime kädessä keskeinen kei...

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Väitöstilaisuus: 29.5.2019

Homo interculturalis – Identity, interculturality and career learning within European Union institutions

Mika Launikari

This research examines the subjective dimensions of intra-EU labor mobility among staff working for decentralized EU agencies located in Greece (Cedefop), Ireland (Eurofound) and Italy (European Training Foundation), and the development of their identity, interculturality and career capitals. The qualitative data for this doctoral dissertation were gathered through thematic interviews he...

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Väitöstilaisuus: 31.5.2019

Life-course determinants of frailty

Markus Haapanen

The proportion of those aged 60 years and older is expected to double from 12 to 24 per cent by the year 2050. The prevalence of frailty increases rapidly with older age and is characterized by loss in biological reserve and resistance to stressors across several physiological systems. Frail people are at an increased risk of adverse health outcomes including hospitalization and prematur...

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Väitöstilaisuus: 31.5.2019

Improving capacity for large-area monitoring of forest disturbance and recovery

Joanne White

Information needs associated with forest monitoring have become increasingly complex. Data to support these information needs are required to be systematically generated, spatially exhaustive, spatially explicit, and to capture changes at a spatial and temporal resolution that is commensurate with both natural and anthropogenic impacts. Moreover, reporting obligations impose additional e...

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Väitöstilaisuus: 31.5.2019

Prolyl oligopeptidase and alpha-synuclein in the regulation of nigrostriatal dopaminergic neurotransmission

Ulrika Julku

Dopamine is one of the main neurotransmitters in the brain. Dopaminergic signalling regulates reward, memory, attention and motor functions. In the synapses of dopaminergic neurons, dopamine transporter (DAT) re-uptakes dopamine into the presynaptic nerve terminals after dopamine release terminating the dopaminergic signal and acting as one of the main regulators for kinetics of dopamine...

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Väitöstilaisuus: 31.5.2019

Abdominal Aortic Infections

Ivika Heinola

Background. Abdominal aortic infections are dreaded disorders in vascular surgery, linked to high morbidity and mortality. Mycotic aneurysm as a primary infection of the abdominal aorta (MAAA) and an aortic graft infection (AGI) are different entities; however, due to bacterial presence in aorta and perivascular tissue, the principles of management are the same. Due to low incidence and ...

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Väitöstilaisuus: 31.5.2019

THE NUP98-NSD1 FUSION GENE IN ACUTE MYELOID LEUKEMIA

Jarno Kivioja

The objective of this thesis was to facilitate molecular detection and treatment of acute myeloid leukemia (AML) patients with recurrent t(5;11)(q35;p15.4) translocation, which joins nucleoporin 98 (NUP98) and nuclear receptor binding SET-domain protein 1 (NSD1) genes together. These patients suffer from a malignant disease with highly unfavorable prognosis and no evidence regarding effi...

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Väitöstilaisuus: 31.5.2019

Jumalan valtakunnan merkki : Kirkon ykseys kommuuniona Wolfhart Pannenbergin ekklesiologiassa

Matti Väätäinen

Ecclesiology has been one of the rising areas in systematic theology in the recent decades. The leading, paradigmatic theme has been communion ecclesiology: the unity of the church and the fellowship of Christians have been understood generally as communion, meaning shared life (koinonia). This kind of koinonia or communion of the church is justified by a trinitarian way on the basis of ...

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Väitöstilaisuus: 1.6.2019

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AGGREGAATTORIT ÄÄNITTEIDEN DIGITAALISESSA JAKELUSSA Tekijänoikeuslainsäädännön ja verotuksen näkökulmasta

Laine, Annina / 27.04.2017

AGGREGAATTORIT ÄÄNITTEIDEN DIGITAALISESSA JAKELUSSA Tekijänoikeuslainsäädännön ja verotuksen näkökulmasta Laine, Annina Tiivistelmä/Referat – Abstract Internet ja digitaalitekniikan kehitys on mullistanut musiikkialaa merkittävästi ja huomattava osa äänitteistä siirtyy nykyään kuuntelijalle digitaalisessa muodossa. Kuluttajille äänitemarkkinoiden digitalisoituminen merkitsee, että mus...

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Kartellivahingon määrän todistaminen vahingonkorvausoikeudenkäynnissä

Korhonen, Sofie / 27.04.2017

Kartellivahingon määrän todistaminen vahingonkorvausoikeudenkäynnissä Korhonen, Sofie Tiedekunta/Osasto Fakultet/Sektion – Faculty Oikeustieteellinen tiedekunta Laitos/Institution– Department Tekijä/Författare – Author Sofie Korhonen Työn nimi / Arbetets titel – Title Kartellivahingon määrän todistaminen vahingonkorvausoikeudenkäynnissä Oppiaine /Läroämne – Subject Oikeustalo...

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The Patent Economics of Synthetic Biology

Bützow, Alexander / 27.04.2017

The Patent Economics of Synthetic Biology Bützow, Alexander Kyseinen työ tutkii uutta bioteknologian muotoa, synteettistä biologiaa, ja sen suhdetta eurooppalaiseen immateriaalioikeuteen, erityisesti patenttioikeuteen. Tutkielman keskeiset kysymykset koskevat sen selvittämisestä, onko 1) synteettisen biologian keksinnöt systeemisesti soveltumattomia nykyiseen patenttioikeuteen, ja 2...

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Vastuun rajoittaminen asianajotoimeksiantosopimukseen perustuvan vastuunhallinnan keinona

Sotamaa, Rasmus / 27.04.2017

Vastuun rajoittaminen asianajotoimeksiantosopimukseen perustuvan vastuunhallinnan keinona Sotamaa, Rasmus Asianajajan mahdollisuuksiin rajata vastuutaan on perinteisesti suhtauduttu varovaisen torjuvasti niin Suomessa kuin muissakin Pohjoismaissa. Torjuvan suhtautumisen perusteet on usein liitetty asianajotoiminnan erityiseen luonteeseen. Vastuunrajoitukset on nähty erityisesti asianaja...

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