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Leaf orientation and the spectral reflectance of field crops

Xiaochen Zou

Leaf angle distribution (LAD) is one of the most important parameters used to describe the structure of horizontally homogeneous vegetation canopies, such as field crops. LAD affects how incident photosynthetically active radiation is distributed on plant leaves, thus directly affecting plant productivity. However, the LAD of crops is difficult to quantify; usually it is assumed to be sp...

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Väitöstilaisuus: 27.5.2015

The health of Finnish Sami in light of mortality and cancer pattern

Leena Soininen

The Sami are regarded as indigenous people of Scandinavia and northwest Russia. Their traditional dwelling zone consists of the most northern parts of those countries. In addition to the Arctic environmental circumstances, some radioactive and chemical pollution has been found in the environment of the Sami. In this study, the mortality and cancer incidence of the Finnish Sami groups (No...

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Väitöstilaisuus: 27.5.2015

Towards bettering HIV/AIDS understandings - A phenomenographic-comparison of the conceptions of HIV-positive university students in Finland and Nigeria

Emmanuel Okwara Kalu

More than half of those newly infected with HIV/AIDS are between the ages of 15 and 24 (UNICEF, UNAIDS and WHO 2002). The disease s challenge is not limited to students already diagnosed with the disease, but also to students in limbo (students who do not know their status), because about 50% of those living with HIV do not know their status (UNAIDS 2012). However, voluntary HIV screenin...

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Väitöstilaisuus: 27.5.2015

Nanoparticle volatility and growth: Implications for interactions between biogenic and anthropogenic aerosol components

Silja Häme

Aerosol particles are important atmospheric constituents. They exist in both polluted and remote areas but the sizes and concentrations of these particles vary greatly depending on location. Aerosol particles damage human health via inhalation, reduce visibility with high mass loadings, and among all, contribute to climate change. Particles directly scatter and absorb solar radiation. In...

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Väitöstilaisuus: 28.5.2015

Fine morphological alterations during brain injury and recovery analyzed with intravital microscopy

Mikhail Kislin

Acute brain trauma and ischemia are severe injuries that have no adequate treatment to date. In vivo two-photon microscopy allows studying longitudinally the process of injury development and brain recovery. This thesis summarizes the work on: i) animal model of acute brain injury and role of extracellular matrix in neuronal recovery and plasticity, ii) investigation of mitochondria duri...

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Väitöstilaisuus: 28.5.2015

The Impact of Tobacco Legislation on Restaurant Workers’ Exposure to Tobacco Smoke in Finland

Jere Reijula

Exposure to tobacco smoke significantly increases the risk of several diseases including cancer, cardiovascular and pulmonary diseases. Prohibition of smoking in workplaces effectively protects workers against occupational exposure to secondhand smoke (SHS). However, Finnish restaurant employees have still been exposed to SHS at work until recent years. In 2000, a reform in tobacco legis...

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Väitöstilaisuus: 28.5.2015

Metaproteomics of the Human Intestinal Tract to Assess Microbial Functionality and Interactions with the Host

Carolin Kolmeder

Human physiological processes are complemented by those of the microbiota, the collection of all microbes living in and on our body. The human intestinal microbiota is one of the most prominent representatives and many associations with a wide spectrum of human diseases have been identified. Analysing faecal material with nucleic acid based approaches revealed the species richness of the...

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Väitöstilaisuus: 28.5.2015

Alkaloids of in vitro cultures of Rhazya stricta

Amir Akhgari

Rhazya stricta Decne. (Apocynaceae) is a traditional medicinal plant in the Middle East and South Asia. It produces a large number of terpenoid indole alkaloids(TIAs), some of which possess important pharmacological properties. This study focused on the establishment of biotechnological production tools of R. stricta, namely undifferentiated cell cultures, and an Agrobacterium rhizogenes...

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Väitöstilaisuus: 29.5.2015

Anthropometric measurements of obesity in relation to mortality and cancer incidence among European adults

Xin Song

Background and aims: Obesity has become the sixth most important risk factor contributing to the overall burden of a variety of diseases worldwide. The association of anthropometric measures of obesity with mortality from various causes and incidence of cancers of various sites has been investigated, but it remains controversial. The aims of this study were to: 1) evaluate the epidemiolo...

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Väitöstilaisuus: 29.5.2015

Calcium A Key Player In Early Neural Development And Migration: TRPCs and VGCCs

Lauri Louhivuori

Signaling pathways linked to changes in the intracellular cytosolic concentrations of free calcium are involved in a plethora of cellular activities ranging from cell division, differentiation and migration, integration of neural circuits, as well as programmed neuronal cell death. Channels that permit the entrance of calcium into neuronal cells have gathered considerable interest due to...

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Väitöstilaisuus: 29.5.2015

Developing a physiotherapeutic testing battery for dogs with stifle dysfunction

Heli Hyytiäinen

Stifle dysfunction is one of the most common reasons for canine hindlimb lameness and an indication for dogs referral to physiotherapy. Until now, there has been a lack of testing batteries in animal physiotherapy, although these are an important part of the evaluation process in various patient groups in human physiotherapy.

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Väitöstilaisuus: 29.5.2015

The long-term outcome of frozen shoulder

Heidi Vastamäki

The purpose of the current study was to assess and report the long-term outcome of frozen shoulder. The 234 patients with 257 frozen shoulders were clinically followed up for a mean 9.7 years (range, 2-30). The study includes five peer-reviewed articles. The specific aims of this project were to study: 1) the long-term outcome of the natural course of idiopathic frozen shoulder, 2) the v...

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Väitöstilaisuus: 29.5.2015

Efficacy, Safety and Clinical Outcomes of Biologic Drugs in the Treatment of Rheumatoid Arthritis

Kalle Aaltonen

Rheumatoid Arthritis (RA) is an autoimmune disease, which is treated with anti-inflammatory and immunosuppressive medication comprising synthetic disease-modifying anti-rheumatic (sDMARDs) and biologic drugs. In this thesis all published randomized controlled trials studying the efficacy and safety of biologic drugs based on the inhibition of tumor necrosis factor (TNF) were identified, ...

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Väitöstilaisuus: 29.5.2015

Candidate therapeutic targets against acute myeloid leukemia identified via screening combinatorial peptide and chemical libraries

Katja Karjalainen

Acute myeloid leukemia (AML), although rare, is highly malignant neoplasms that account for a majority of leukemia-associated deaths. AML results from an over-growth of immature myeloid cells in the bone marrow. These cells are functionally abnormal and interfere with the production of normal hematopoietic cells. Despite apparent phenotypic uniformity, AML is a heterogeneous group of mye...

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Väitöstilaisuus: 29.5.2015

TUMOUR GLYCOSYLATION AND GLYCOPROTEINS AS BIOMARKERS IN COLORECTAL CANCER

Tuomas Kaprio

Colorectal cancer (CRC) is one of the world s three most common cancers, and its incidence is rising. Novel biomarkers are essential for diagnostic and prognostic tools and to identify patients for targeted and individualized therapy. Covering all human cells, the carbohydrate units of glycoproteins, glycolipids, and proteoglycans are glycans. Carcinoma-related glycan structures are pote...

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Väitöstilaisuus: 29.5.2015

Natural stimuli and experimental setups in the study of the neural basis of social interaction

Lotta Hirvenkari

Social interaction consists of events of different modalities that unfold on a subsecond timescale and are usually influenced by all involved participants. Therefore, social interaction is difficult to be simulated in laboratory, as simple, static, and unidirectional stimuli and tasks do not cover its properties accurately enough. However, moving towards more natural experimental setups ...

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Väitöstilaisuus: 29.5.2015

Ice formation, growth and associated substrate supply determine sea-ice bacterial community dynamics

Eeva Eronen-Rasimus

Sea ice, at its maximum extent, is one of the largest biomes on Earth. In addition to the polar oceans, it covers extensive sea areas at lower latitudes such as the Baltic Sea and the Sea of Okhotsk. During ice formation, organic and inorganic components in the parent seawater are concentrated into saline brines within the ice, which serve as a habitat for diverse auto- and heterotrophic...

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Väitöstilaisuus: 29.5.2015

DIAGNOSIS AND TREATMENT OF PREMALIGNANT CHANGES OF PHOTODAMAGED SKIN: Novel Hyperspectral Imaging and New Therapeutical Aspects

Noora Neittaanmäki-Perttu

ABSTRACT Background and purpose: As the skin cancer burden continues to increase, there is an urgent need for novel methods for the early detection of skin cancers, and for new cost-effective treatments. The hyperspectral imaging system (HIS) is a novel technique which offers the dual advantages of allowing the imaging of large skin areas rapidly and non-invasively. Daylight photodynamic...

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Väitöstilaisuus: 29.5.2015

Collaborative knowledge construction in the context of problem-based learning - Exploring learning from conflicting ideas and knowledge

Matti Aarnio

Today's medical education faces the challenge of developing students competencies to resolve ever more complex problems in collaboration with other professionals. Problem-based learning (PBL) has proven useful for developing many of the competencies needed in modern healthcare. In PBL students collaboratively construct knowledge to explain and solve problems related to real-life situatio...

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Väitöstilaisuus: 30.5.2015

Cell-based bioluminescent high-throughput screening methods in antibacterial drug discovery

Susanna Nybond

Due to the emergence of multidrug resistant bacteria, bacterial infections are still a major healthcare problem. Many factors have led to a discovery void of new antibacterial agents, rendering the current antibiotic pipeline inadequate for future medical needs. For example, the outcomes from pure biochemical high-throughput screening (HTS) assays have, in many cases, not led to successf...

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Väitöstilaisuus: 4.6.2015

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Kiinteässä tilassa olevan selluloosan kemiallinen muokkaus & Selluloosan asylointireaktion kontrollointi ionisissa nesteissä ja liuotinsysteemeissä

Iivanainen, Tatu / 20.05.2015

Kiinteässä tilassa olevan selluloosan kemiallinen muokkaus & Selluloosan asylointireaktion kontrollointi ionisissa nesteissä ja liuotinsysteemeissä Iivanainen, Tatu Tässä tutkielmassa on perehdytty kirjallisuuskatsauksen avulla kiinteässä tilassa olevan selluloosan muokkaukseen kiinteitä, nestemäisiä ja kaasumaisia reagensseja käyttäen sekä erilaisiin selluloosan aktivointitapoihin m...

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Kehittämistutkimus: Orgaanisten yhdisteiden hapetus-pelkistysreaktioiden kokeelliset työt lukion kemian oppimisen tukena

Vilen, Heli / 20.05.2015

Kehittämistutkimus: Orgaanisten yhdisteiden hapetus-pelkistysreaktioiden kokeelliset työt lukion kemian oppimisen tukena Vilen, Heli Orgaanisten yhdisteiden hapetus-pelkistysreaktiot ovat yksi keskeisimmistä reaktiotyypeistä orgaanisessa kemiassa. Nämä reaktiot ovat tärkeä orgaanisen kemian sisältö myös lukion opetussuunnitelman perusteissa. Kokeellisuus on kemialle luonteenomainen tied...

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Laskennallinen tutkimus rikkihappoa sisältävien klustereiden muodostumisesta ilmakehässä

Nanna, Myllys / 20.05.2015

Laskennallinen tutkimus rikkihappoa sisältävien klustereiden muodostumisesta ilmakehässä Nanna, Myllys Ilmakehässä tapahtuva hiukkasmuodostus on tärkeä tutkimuskohde, sillä muodostuvat sekundäärihiukkaset vaikuttavat ihmisten terveyteen ja maapallon säteilytasapainoon. Hiukkasmuodostuksen ensiaskeleista ei ole toistaiseksi tarkkaa tietoa, mutta laskennallisten ja kokeellisten tutkimusten...

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Ihmis- ja kulttuurikuva suomalaisissa esihistorian näyttelyissä

Rönkä, Minna / 22.05.2015

Ihmis- ja kulttuurikuva suomalaisissa esihistorian näyttelyissä Rönkä, Minna Tässä työssä tutkin ihmis- ja kulttuurikuvaa seitsemässä suomalaisessa esihistorian näyttelyssä. Tarkastelen näyttelyä mediaesityksenä eli representaationa, joka ei välitä neutraalia tai totuudenmukaista kuvaa esihistoriasta, vaan jonka välittämän menneisyyskuvan taustalla ovat oman aikamme tulkinnat, oletukse...

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