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GENETICS OF PRIMARY IMMUNODEFICIENCY IN FINLAND

Luca Trotta

Primary Immunodeficiency (PIDs) categorize a broad and heterogeneous group of inborn immunity errors. Despite being generally quite rare, PIDs collectively account for consistent morbidity and mortality. Currently, more than 350 monogenic PIDs have been recognised to embody clinical phenotypes ranging from life-threatening infections to autoimmune/inflammatory diseases, allergies and/or ...

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Väitöstilaisuus: 24.1.2019

Take not Jews and Christians as Intimates! : Depictions of Jews and Christians in Modern Shīʿi Qurʾānic Exegesis

Maria Pakkala

Modern Shīʿi commentaries on the Qurʾān are understudied in comparison with their classical or Sunni counterparts. This dissertation attempts to fill in some of this academic lacuna by shedding light on one of the major Shīʿi Qurʾānic commentators of our times. The topic of my research is the perception of Jews and Christians in the thought of the Lebanese Shīʿi scholar Grand Ayatollah a...

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Väitöstilaisuus: 25.1.2019

Developing official control in Finnish slaughterhouses

Jenni Luukkanen

Official control in slaughterhouses, consisting of meat inspection and food safety inspection, has an important role in ensuring meat safety, animal health and welfare, and prevention of transmissible animal diseases. Meat inspection in the European Union (EU) includes the inspection of food chain information, live animals (ante-mortem inspection), and carcasses and offal (post-mortem in...

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Väitöstilaisuus: 25.1.2019

Visualizing congestion with ultrasound - diagnostic and therapeutic implications

Jonas Öhman

The syndrome of Acute Heart Failure (AHF) is a very common cause for hospitalization, and carries a poor prognosis both in hospital and after discharge. The syndrome is caused by a various disease of the cardiovascular system and the heart. Congestion due to elevated cardiac filling pressures is the key physiological feature in AHF. There is to date very little evidence-based therapy exi...

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Väitöstilaisuus: 25.1.2019

Arterial Embolization in Gastrointestinal Bleeding

Taina Nykänen

Gastrointestinal bleeding is a common surgical emergency resulting in significant morbidity and mortality. The first line intervention in most cases is therapeutic endoscopy. When endoscopy fails or is not feasible, the traditional second line treatment is surgery. Emergency surgery is associated with significant morbidity and mortality, and the less invasive transcatheter arterial embol...

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Väitöstilaisuus: 25.1.2019

Kolme kriisiä ja kansalliset rahapelit : Yhteiskunnallisten murroskausien vaikutus suomalaisen rahapelijärjestelmän muotoutumiseen

Jukka Ahonen

The study analyzes the historical formation of the Finnish gambling system with particular focus on non-economic factors related to the legalization of gambling. The development of the gambling system is examined from the perspective of three periods which turn out to be critical turning points in society. Firstly, the start of football pools during the year of the Winter War, 1940, and ...

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Väitöstilaisuus: 25.1.2019

Obesity and associated health risks - outcomes of maternal early pregnancy obesity and child's cognition

Satu Kumpulainen

Alarming rates of the world’s adult population is meeting the criteria for obesity. Moreover, increasing amount of women at reproductive age are entering pregnancy with obesity. Growing evidence suggests that excessive maternal weight during pregnancy does not only pose a risk for poorer maternal physical and mental health but is also resulting in adverse outcomes in offspring. One of th...

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Väitöstilaisuus: 25.1.2019

Masentuneen elämänhallinnan tukeminen perusterveydenhuollossa

Anneli Kuusinen-Laukkala

Depression is a multi-faceted syndrome both in view of the background and support, treatment and rehabilitation and thus a big challenge in the whole society. To be able to prevent and treat it individually we need multiple ways to recognize determinants and risk factors of depression. The family, the nearests and the work are in the main role in developing and supporting the sense of co...

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Väitöstilaisuus: 25.1.2019

Chlamydia trachomatis and Reproductive health

Tiina Rantsi

Chlamydia trachomatis infection is the most common bacterial sexually transmitted infection (STI) worldwide. It has been linked to severe reproductive morbidity, including tubal factor infertility (TFI), ectopic pregnancy (EP), miscarriage and preterm delivery (PTD), but the evidence has mostly been based on clinical case-control studies, and the data retrieved from population-based stud...

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Väitöstilaisuus: 25.1.2019

Underlying Mechanisms of Prolyl Oligopeptidase Inhibition, Deletion, and Restoration on the α-Synuclein Aggregation Process

Reinis Svarbachs

Neurodegenerative disorders are characterized by accumulation of toxic protein species that are followed by a gradual loss of neurons in certain brain regions and person’s loss of movement and dementia. The cause of the protein accumulation is not fully understood but is partially influenced by the disturbances in the protein degradation pathways, post-translational protein modifications...

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Väitöstilaisuus: 25.1.2019

Glucuronidation activity of individual UDP-glucuronosyltransferases : Comparison of activity and substrate specificity among recombinant human UGT enzymes and differences between dog and human subfamily 1A UGT enzymes

Johanna Troberg

UDP-glucuronosyltransferases (UGTs) are a group of important conjugation enzymes that transfer a sugar moiety from UDP-glucuronic acid onto a nucleophilic group in substrate compounds. This glucuronidation reaction converts compounds into more water-soluble forms, and thereby enhances their excretion into bile, feces or urine. Frequently prescribed drugs are often eliminated through gluc...

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Väitöstilaisuus: 25.1.2019

Studies on Neural Mechanisms Underlying Emotions : Experiments with pharmaceutical and physiological stimuli on behavior and brain signals in rodents and non-human primates

Zuyue Chen

This thesis investigated aspects of emotion processing by applying behavioral testing, pharmacological manipulations and electrophysiological recordings in animal experiments, and focused on questions that have relevance in understanding human emotion processing. Studies I and II aimed at elucidating whether paracetamol, a widely used pain-killer and fever-reducing medication, might also...

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Väitöstilaisuus: 25.1.2019

Associations between circadian factors and noncommunicable diseases; A population-based study in Finland

Syaron Basnet

The aim of this thesis was to study the association between circadian factors and common noncommunicable diseases. To our knowledge, these associations have not been investigated before in a large population-based cohort. The study of these associations is important as the global morbidity and mortality rates for noncommunicable diseases are increasing. Thus, there is a need to better un...

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Väitöstilaisuus: 25.1.2019

Perception, action and attention in locomotor control : An experimental and computational investigation of driving

Jami Pekkanen

This thesis is an inquiry into how humans use their imperfect perception, limited attention and action under uncertainty to successfully conduct time-critical tasks. This is done in four studies. The experimental task in the first two is car following while being visually distracted. The third study presents a new method for analyzing eye-movement signals recorded in challenging recordin...

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Väitöstilaisuus: 28.1.2019

LONG-TERM OUTCOME OF YOUNG ADULTS WITH ISCHEMIC STROKE

Karoliina Aarnio

Ischemic stroke (IS) is one of the most common causes of death and disability worldwide. Around 10% of ISs affect young adults less than 50 years of age. Incidence of IS in young adults is approximately 10-20/100 000 people per year in the developed countries. Young patients typically have many years of active life ahead, and have families and work to take care of. Therefore, their long-...

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Väitöstilaisuus: 1.2.2019

GENETICS OF DIVERSE PHENOTYPES IN HIRSCHSPRUNG DISEASE - EXTENSION OF AGANGLIONOSIS, HEREDITY AND MEDULLARY THYROID CARCINOMA

Valtter Virtanen

The aim of this doctoral thesis was to identify the genetic variations of Hirschsprung disease (HD) among Finnish HD patients. How the different genotypes affect different HD phenotypes, such as the extension of aganglionosis, heredity, and HD-associated medullary thyroid cancer (MTC) was also explored. The entire patient cohort consisted of 112 HD patients. Of them, 91 adult HD patients...

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Väitöstilaisuus: 1.2.2019

Cardiovascular risk factors among Russian, Somali and Kurdish origin populations in Finland

Natalia Skogberg

Cardiovascular diseases (CVDs) are the leading cause of death globally. To a large extent, CVDs can be prevented through following healthy lifestyles. Cardiovascular risk factors have been regularly monitored at a national level in a number of high-income countries, including Finland. This monitoring data has been utilised in decision making and service planning to reduce regional and so...

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Väitöstilaisuus: 1.2.2019

Statistical analysis of aerosol mass spectra - chemometrics and chemical speciation

Mikko Äijälä

Climate change and degraded air quality rank among the most severe environmental problems that humanity currently faces. Atmospheric aerosols - the fine particles suspended in air – play a significant role in both of them. Aerosols affect Earth’s radiation balance via their interactions with radiation (scattering and absorption of light) and atmospheric water vapour (cloud formation, lif...

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Väitöstilaisuus: 1.2.2019

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AGGREGAATTORIT ÄÄNITTEIDEN DIGITAALISESSA JAKELUSSA Tekijänoikeuslainsäädännön ja verotuksen näkökulmasta

Laine, Annina / 27.04.2017

AGGREGAATTORIT ÄÄNITTEIDEN DIGITAALISESSA JAKELUSSA Tekijänoikeuslainsäädännön ja verotuksen näkökulmasta Laine, Annina Tiivistelmä/Referat – Abstract Internet ja digitaalitekniikan kehitys on mullistanut musiikkialaa merkittävästi ja huomattava osa äänitteistä siirtyy nykyään kuuntelijalle digitaalisessa muodossa. Kuluttajille äänitemarkkinoiden digitalisoituminen merkitsee, että mus...

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Kartellivahingon määrän todistaminen vahingonkorvausoikeudenkäynnissä

Korhonen, Sofie / 27.04.2017

Kartellivahingon määrän todistaminen vahingonkorvausoikeudenkäynnissä Korhonen, Sofie Tiedekunta/Osasto Fakultet/Sektion – Faculty Oikeustieteellinen tiedekunta Laitos/Institution– Department Tekijä/Författare – Author Sofie Korhonen Työn nimi / Arbetets titel – Title Kartellivahingon määrän todistaminen vahingonkorvausoikeudenkäynnissä Oppiaine /Läroämne – Subject Oikeustalo...

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The Patent Economics of Synthetic Biology

Bützow, Alexander / 27.04.2017

The Patent Economics of Synthetic Biology Bützow, Alexander Kyseinen työ tutkii uutta bioteknologian muotoa, synteettistä biologiaa, ja sen suhdetta eurooppalaiseen immateriaalioikeuteen, erityisesti patenttioikeuteen. Tutkielman keskeiset kysymykset koskevat sen selvittämisestä, onko 1) synteettisen biologian keksinnöt systeemisesti soveltumattomia nykyiseen patenttioikeuteen, ja 2...

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Vastuun rajoittaminen asianajotoimeksiantosopimukseen perustuvan vastuunhallinnan keinona

Sotamaa, Rasmus / 27.04.2017

Vastuun rajoittaminen asianajotoimeksiantosopimukseen perustuvan vastuunhallinnan keinona Sotamaa, Rasmus Asianajajan mahdollisuuksiin rajata vastuutaan on perinteisesti suhtauduttu varovaisen torjuvasti niin Suomessa kuin muissakin Pohjoismaissa. Torjuvan suhtautumisen perusteet on usein liitetty asianajotoiminnan erityiseen luonteeseen. Vastuunrajoitukset on nähty erityisesti asianaja...

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