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Microvascular reconstruction of traumatic compound bone and soft tissue defects of the tibia and ankle - Long-term patient-reported outcomes

Jussi Repo

Extensive compound fractures with bone and soft tissue defects or sequelae of prolonged complications in the tibia and the ankle region can be treated with microvascular reconstruction techniques in selected patients. The aim of this study was to assess the reliability and validity of the new Finnish version of the Lower Extremity Functional Scale (LEFS) among foot and ankle patients and...

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Väitöstilaisuus: 20.1.2017

Towards more profitable and sustainable milk and beef production system

Pauliina Kokko

Achieving and maintaining national self-sufficiency in milk and meat play important roles in ensuring future food security. Currently, Finland is self-sufficient in milk. However, beef production, which is strongly related to dairy production, has fallen below consumption mainly because of a decreased number of dairy cows and low profitability. Even though the efficiency and productivity...

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Väitöstilaisuus: 20.1.2017

Tammerkosken kansallismaisema teollisuusperintönä - Verkatehtaasta Finlaysoniin 1965-2005

Marja Lähteenmäki

Purku-uhan alla olevat tehdasrakennukset herättävät nykyään Tampereella kiihkeää keskustelua. Miksi tehtaista tuli niin tärkeitä tamperelaisille, ettei niiden purkaminen ollut enää ensisijainen ja ainoa vaihtoehto? Tässä tutkimuksessa kuvataan miten tehdasrakennuksista tuli suojelukohteita. Verkatehtaan ja Finlaysonin tapausten (1965 2005) kautta tutkitaan myös laajempia yhteiskunnallisi...

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Väitöstilaisuus: 20.1.2017

Improving adenovirus-based immunotherapies for treatment of solid tumors

Mikko Siurala

New treatment modalities are needed for patients with advanced cancer, who have undergone several unsuccessful pretreatments. Cancer immunotherapy has emerged as a promising field of medicine with the potential to induce durable responses in these patients. Within the immunotherapy field, a diverse set of approaches have been employed, all of which aim at combating tumors with the cells ...

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Väitöstilaisuus: 20.1.2017

Delayed puberty: etiology, outcome and interactions with growth

Tero Varimo

During puberty, adolescents achieve reproductive capability and attain adult height. An intact hypothalamic-pituitary-gonadal (HPG) axis is crucial for the normal onset of puberty. Pubertal timing is influenced by genetic and environmental factors, but the exact mechanisms that trigger puberty remain elusive. A finding of a paternally-inherited loss-of-function mutation in makorin ring f...

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Väitöstilaisuus: 20.1.2017

Impacts of restoration of forestry-drained peatlands on nutrient and organic carbon exports and methane dynamics

Markku Koskinen

In this study, the effects of restoration of forestry-drained peatlands on the nutrient and organic carbon exports and methane dynamics of the restored sites are explored. The study consists of four sub-studies. Two of the sub-studies are concerned with the effects on water quality and export of elements of restoration and were conducted on a catchment scale. One of the studies was condu...

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Väitöstilaisuus: 20.1.2017

The role of cortical oscillations in the estimation and maintenance of sensory and duration information in working memory

Shrikanth Kulashekhar

Working memory is used to maintain information for cognitive operations, and its deficits are associated with several neuropsychological disorders. Human functional magnetic resonance imaging (fMRI) f isolated key brain areas associated with the maintenance of sensory and duration information. However, the systems-level mechanisms coordinating the collective neuronal activity in these br...

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Väitöstilaisuus: 20.1.2017

Effects of microsurgical nerve repair on sensory function after breast reconstruction

Helena Puonti

A beautiful, naturally-shaped and symmetrical breast mound will be created for a breast cancer patient after mastectomy using a free abdominal flap. The disadvantage with the breast reconstructed with this method is its lack of sensation, even some spontaneous reinnervation takes place from the surrounding tissues. The objective of the present study was to find and develope a method of d...

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Väitöstilaisuus: 27.1.2017

A Conversation Analysis of Social Interaction in the Functional Capacity Interview

Mika Simonen

This ethnomethodological conversation analysis study investigates how functional capacity interviews are organized in social interaction, thereby documenting recurrent assessment practices. Although interviewing is respected, due to its centrality in knowledge production in contemporary society, little is known about conducting functional capacity interviews per se. Moreover, as demonstr...

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Väitöstilaisuus: 27.1.2017

Optimization of early cleaning and precommercial thinning methods in juvenile stand management of Norway spruce stands

Karri Uotila

The purpose of the work done for this thesis was to construct and develop the concept of cost-efficient Juvenile Stand Management (JSM) for planted Norway spruce (Picea abies L. Karst) stands. The principles of time based management were followed, by integrating regeneration activities as a cost-efficient value chain and by minimizing non-value-adding work with straightforward decision m...

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Väitöstilaisuus: 27.1.2017

Clinical and genetic risk factors in acute coronary syndromes

Satu Vaara

Coronary artery disease (CAD), acute coronary syndromes (ACS), and other conditions related to atherosclerosis are leading causes of death in developed countries. The incidence of CAD cannot be explained only by clinical risk factors, such as hypertension, dyslipidemia, diabetes and smoking; the genetics also matters. Major findings concerning the genetics of CAD have emerged during the ...

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Väitöstilaisuus: 27.1.2017

Unity or Diversity? - Turkish Nationalism, Kurds, and the Turkish Mainstream Press

Anu Leinonen

This work examines: 1) how Kurds and their demands for cultural and political rights were represented in the Turkish-language mainstream press (1999 2005), and 2) the debates over proposals to change the conceptualizations of the citizenship of Turkey within attempts for a resolution to Turkey s Kurdish issue (in 2005 and 2009). To achieve this, news and columns published in the Milliyet...

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Väitöstilaisuus: 27.1.2017

Poliittinen prosessi ja demokratiakokeilujen tartunnat koulun arjessa

Tuure Tammi

Miten poliittisuutta voitaisiin ymmärtää koulun arjessa tapahtuvana prosessina? Miten siihen voitaisiin koulussa tarttua demokraattista keskustelua ja päätöksentekoa harjoittamalla? Muun muassa näitä kysymyksiä kartoittava väitöskirjani koostuu neljästä osatutkimuksesta sekä yhteenveto-osiosta. Osatutkimuksissa tarkastelen kouluun yhdistyviä demokratiakokeiluita. Yhteenvedossa ajattelen ...

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Väitöstilaisuus: 27.1.2017

Globus and dysphagia - clinical features and diagnostics

Pia Järvenpää

Globus, a non-painful sensation of a lump in the throat, is a common symptom; however, little is known about the etiology, and the causes have remained controversial. Dysphagia is a multifaceted symptom. Identifying the stage of the swallowing process at which the problem occurs directs us to possible further investigations in dysphagia diagnostics. The aim of this thesis was to investig...

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Väitöstilaisuus: 27.1.2017

In your Light we see the Light - Martin Luther’s Understanding of Faith and Reality between 1513 and 1521

Ilmari Karimies

The aim of the dissertation is to investigate and clarify Martin Luther's understanding of faith and of reality in his biblical lectures between the years 1513 and 1521. The method of the study is systematic analysis. With regard to its content the work can be seen as an investigation of the history of ideas or dogma. The general context of the study is the examination of the cognition o...

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Väitöstilaisuus: 27.1.2017

Biomarkers of chronic allograft injury in children after renal transplantation

Jenni Miettinen

Renal transplantation (RTx) is a treatment of choice for children with end-stage renal disease. Excellent short-term survival is followed by moderate long-term results, and a considerable number of kidney grafts fail over the decades. Chronic allograft injury (CAI) is a multifactorial entity that manifests as a progressive deterioration of glomerular filtration rate (GFR), and histopatho...

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Väitöstilaisuus: 27.1.2017

Self-control, social cognitions, and automatic social images: Insights into determinants of healthy lifestyle among young men in military service

Marja Kinnunen

Despite being aware of public health guidelines, young men often consume too little vegetables, too much fast food, are quite inactive, and have relatively poor fitness levels. The aims were to examine the following: Is higher self-control associated with improved health behaviors, better fitness, and lower Body Mass Index (BMI)? Is the healthier eating of people with high self-control a...

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Väitöstilaisuus: 27.1.2017

Ecological fitness and interspecies interactions of food-spoilage-associated lactic acid bacteria: insights from the genome analyses and transcriptome profiles

Margarita Andreevskaya

Lactic acid bacteria (LAB) play a dual role in food manufacturing. While being indispensable for food fermentations and preservation, they are also involved in spoilage of foods and beverages, and some food-borne LAB are pathogens. Particularly, they became the main spoilage organisms in the cold-stored modified atmosphere packaged (MAP) foods. LAB species composition and their relative ...

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Väitöstilaisuus: 28.1.2017

Considering Character and Excuses as Blame Mitigation - A Comparative Analysis of Strawsonian and Aristotelian Accounts of Moral Responsibility

Eero Kaila

This dissertation is aimed at clarifying the concept of moral responsibility within Anglophone, analytic ethics broadly defined, as well as looking at the concept of character to inquire about its role embedded within these theories. In this work, it is claimed that considerations of character matter when moral responsibility is assessed.

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Väitöstilaisuus: 28.1.2017

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HPV:n aiheuttamien kohdunkaulan solumuutosten diagnostiikka papan ja kolposkopian avulla: retrospektiivinen tutkimus

Leino, Kristina / 16.01.2017

HPV:n aiheuttamien kohdunkaulan solumuutosten diagnostiikka papan ja kolposkopian avulla: retrospektiivinen tutkimus Leino, Kristina Kohdunkaulasyövän seulontojen löydösten ja niitä seuraavien jatkotutkimustulosten korrelaatiosta ei ole Suomessa tehty riittävästi kattavia tutkimuksia. Tutkimuksemme tavoitteena oli tutkia kolposkopiassa käyneiden naisten tulo-papan, kolposkopian yhteydess...

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Retrospektiv undersökning angående livmoderhalscellförändringarnas loop-behandling och dess komplikationer

Mehrabkhani, Soroush / 16.01.2017

Retrospektiv undersökning angående livmoderhalscellförändringarnas loop-behandling och dess komplikationer Mehrabkhani, Soroush Målet med undersökningen är, att samla information av patienter angående loop-behandling på grund av cellförändringar i livmoderhalsen som orsakas av papillomvirus, HPV. Vissa av dessa förändringar kräver inga åtgärder, medan andra svårare förändringar kräver lo...

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Diversity of leisure-time sport activities in adolescence as a predictor of leisure-time physical activity in adulthood

Mäkelä, Sara / 16.01.2017

Diversity of leisure-time sport activities in adolescence as a predictor of leisure-time physical activity in adulthood Mäkelä, Sara; Aaltonen, Sari; Korhonen, Tellervo; Rose, Richard J.; Kaprio, Jaakko Abstract Because sustained physical activity is important for a healthy life, this paper examined whether a greater diversity of sport activities during adolescence predicts higher le...

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Identification of homozygous deletion in ACAN and other candidate variants in familial classical Hodgkin lymphoma by exome sequencing

Ristolainen, Heikki / 16.01.2017

Identification of homozygous deletion in ACAN and other candidate variants in familial classical Hodgkin lymphoma by exome sequencing Ristolainen, Heikki; Kilpivaara, Outi; Kamper, Peter; Taskinen, Minna; Saarinen, Silva; Leppä, Sirpa; d'Amore, Francesco; Aaltonen, Lauri A. Tutkimuksessamme tarkastelimme Lähi-idästä lähtöisin olevaa perhettä, jossa kolmella viidestä lapsesta on todettu n...

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