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Carbon dioxide-based syntheses of oxazolidinones and other cyclic carbamates

Teemu Niemi

Carbon dioxide is often considered a comparatively unreactive molecule due to its nonpolar nature and the presence of strong double bonds. However, its electron-deficient carbon atom is susceptible to nucleophilic attack, a property that has been exploited in organic synthesis for well over a century. If the nucleophilic attack is performed by an amine, a carbamate species is formed. Th...

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Public examination: 28.9.2018

Soil changes and long-term ecosystem recovery from physical and chemical load – stump harvesting and sprinkling infiltration as case studies

Lilli Kaarakka

Human-induced disturbances may change vegetation and carbon (C) and nitrogen (N) processes in the forest floor and the soil beneath it. The aim of this dissertation was to study the effects of physical and chemical disturbance on boreal forest soil and vegetation. Two contrasting soil-affecting treatments – stump harvesting and sprinkling infiltration – were studied as case studies. Spri...

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Public examination: 28.9.2018

The Value of Patient Reporting of Adverse Drug Reactions to the Pharmacovigilance Systems

Pedro Inacio

Patient reporting of adverse drug reactions (ADRs) has become an important element of pharmacovigilance. The aim of this thesis was to research the value of patient reporting of ADRs to pharmacovigilance systems. The study consists of 4 original studies, of which study I and II are interrelated. Study I identified which are the clinical and subjective aspects of adverse drug reactions (A...

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Public examination: 28.9.2018

Acute phase proteins in healthy and sick dairy and beef calves and their association with growth

Leena Seppä-Lassila

The acute phase response (APR) is a component of the innate immune system, a general and non-specific response that limits the spread of infection and removes factors potentially harmful to the body. Infection, neoplasm or tissue trauma initiates an acute phase response, resulting in visible systemic signs of illness, fever, reduction of appetite and depression. APR also induces a variet...

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Public examination: 28.9.2018

Long-acting reversible contraception (LARC) after medically induced abortion

Riina Korjamo

The total number of induced abortions has declined, but the 32–45% proportion of repeat abortions has remained stable. Medical abortion has replaced the surgical method and up to 97% of abortions are medically induced today in Finland. Long-acting reversible contraception (LARC), i.e., intrauterine devices and contraceptive implants, is very effective. Initiation of LARC methods at the t...

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Public examination: 28.9.2018

Emotions and psychophysiological responses in organizational social interaction

Mikko Salminen

Emotions have various effects in work life and in organizational social interaction. Daily work events evoke emotional reactions, which are communicated to colleagues and clients. The communicated emotions may evoke corresponding affective response in the perceiver and, thus, the emotions become social. Existing emotional state may have an effect on the performance of work tasks, such as...

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Public examination: 28.9.2018

CHRONIC DENTAL DISEASES AND SYSTEMIC HEALTH: CARDIOVASCULAR DISEASES AND CANCER

Eunice Virtanen

Chronic dental diseases are highly prevalent worldwide. The possible associations between oral diseases and general health have been studied and periodontitis has been associated with cardiovascular diseases, diabetes, pre-term and low-birth weight infants, Alzheimer’s disease, and also with cancer. Apical periodontitis associates with cardiovascular diseases and diabetes. Nevertheless, ...

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Public examination: 28.9.2018

Restricted energy intake strategies for growing and finishing dairy bulls offered grass silage-based diets

Katariina Manni

Beef production in Finland is mostly based on dairy breeds. To compensate for the lack of domestic beef, slaughterhouse pricing favours lean and heavy carcasses. Higher carcass weights increase the probability of increasing fatness. It is necessary to control fatness because consumers generally favour low-fat products. In addition, excessive fat accumulation decreases the efficiency of f...

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Public examination: 28.9.2018

Analysing Ecological Communities with Joint Species Distribution Models

Anna Norberg

In community ecology, we are interested in the patterns of occurrence and abundance of multiple species coexisting and interacting in an area or habitat. There is a large array of modelling methods that can be used as species distribution models, each of which based on different assumptions on how the surrounding conditions affect the distribution of species and communities. Teasing apar...

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Public examination: 28.9.2018

An integrative perspective on visitor spatial behaviour in urban green spaces : Linking movement, motivations, values and biodiversity for participatory planning and management

Silviya Korpilo

Understanding use by and movement of people in urban green spaces is important to planning and management in order to balance between multiple user needs and the preservation of natural resources as ecologically and socially viable. Yet, in the current literature, little attention is paid to the intraspatial (i.e. within the area) behaviour of visitors and how this relates to the socio-e...

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Public examination: 28.9.2018

Inhalable antifibrotic compounds - Development of a formulation method and formulation of antifibrotic small molecule tilorone as inhalable dry powder

Ville Vartiainen

The purpose of this work was to develop a formulation method to produce high quality inhalable dry powder, to formulate an anti-fibrotic small molecule tilorone to a respirable form, and to assess its anti-fibrotic potential in pulmonary administration. The aerosol flow reactor method was used to produce carrier-free formulations of water soluble and insoluble drugs as well as combinati...

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Public examination: 28.9.2018

FANCM Mutations in Breast Cancer Risk and Survival

Johanna Kiiski

Breast cancer is the most diagnosed malignancy and the leading cause of cancer mortality in women worldwide. In Finland, approximately 5,000 cases are diagnosed annually, constituting about 30% of all new female cancers. Although commonly referred to as a single disease, breast cancer is a clinically and morphologically heterogeneous disorder. Different histologic and molecular subtypes ...

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Public examination: 28.9.2018

International Organisations and the Securitisation of the Environment in Post-Conflict Western Balkans

Emma Hakala

Environmental security is broadly defined as a concept concerned with the relationship of threats between environmental change and human society. While its focus often is on the consequences of environmental threats like pollution and climate change, it also entails the potential of environment to serve as a basis for cooperation. This Doctoral dissertation is a historical analysis of th...

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Public examination: 29.9.2018

Health-related quality of life in patients with chronic pain

Pekka Vartiainen

Chronic pain impairs health and both physical and cognitive function, and is associated with considerable psychosocial problems. The management of chronic pain is challenging, and multidisciplinary pain management (MPM) is considered the most efficacious method of treating chronic pain. However, treatment outcomes vary greatly, and it is not possible to predict which patients will benefi...

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Public examination: 29.9.2018

Pietististä humanistiksi? : Olavi Kares herännäisyyden, kirkon ja yhteiskunnan muutoksen keskellä 1945 - 1974

Kimmo Ylikangas

Olavi Kares (1903–1988) oli yksi toisen maailmansodan jälkeisen ajan keskeisimmistä herännäisvaikuttajista. Hän oli myös merkittävä kirkollinen vaikuttaja. Tutkimukseni lähtökohta on, että Kareksessa tapahtui aatteellinen ja uskonnollis-teologinen muutos. Selvitän, miten hänen ajattelunsa muuttui, mistä muutokset johtuvat ja mitä vaikutuksia tällä muutoksella oli. Toisen maailmansodan jä...

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Public examination: 29.9.2018

Hijacking responsibility - Philosophical studies on health distribution

Johanna Ahola-Launonen

In this thesis, I examine the theoretical background of a political trend, namely, the responsibilization of the individual. The trend turns complex societal issues like poverty and sickness into simple questions of individual responsibility. I show that what underlies it is a simplified and misunderstood version of luck egalitarianism, or responsibility-sensitive egalitarianism. The the...

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Public examination: 2.10.2018

Essays on Pharmaceutical Policies and Markets

Olena Izhak

The thesis is a collection of three essays analyzing pharmaceutical markets and regulations. In the first chapter using the Finnish prescription registry I empirically evaluate how the probability of substitution of a prescribed drug in a pharmacy depends on the pharmacists' profits and patients' out of pocket costs. I find that the more pharmacists stand to loose from successful substit...

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Public examination: 3.10.2018

Lääkkeisiin ja lääkkeen kaltaisiin tuotteisiin liittyvät toiveet ja illuusiot - psykodynaaminen näkökulma

Ilari Sirenius

Tutkimuksessa tarkastellaan lääkkeisiin ja lääkkeen kaltaisiin tuotteisiin liittyviä toiveita ja illuusioita psykodynaamisestä näkökulmasta. Kirjallisuuskatsauksessa tarkastellaan lääkeinformaation ja lääkeneuvonnan kehittymistä, hoitomyönteisyyttä ja hoitoon sitoutumista sekä kuvataan lääkkeiden käyttöön liittyvää psykodynaamista ajattelua: ihmisen mielen maailmaa ja sen kehittymistä ja...

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Public examination: 4.10.2018

Experience in Michel Foucault's Philosophy

Sanna Tirkkonen

In everyday language the word “experience” is used in different senses: it might refer to a subjective phenomenon, expertise that is gained through time or something people have in common and share with others. Scientific, experiential knowledge is commonly considered opposite to personal experience. In the history of Western thinking, however, “experience” is frequently associated with ...

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Public examination: 5.10.2018

PRETARGETED PET IMAGING OF POROUS SILICON NANOPARTICLES AND MONOCLONAL ANTIBODIES - DEVELOPMENT OF 18F-FLUOROGLYCOSYLATED TETRAZINE TRACER FOR THE IEDDA REACTION IN VIVO

Outi Keinänen

Positron emission tomography (PET) is a sensitive and quantitative molecular imaging method. Nowadays PET is widely used in the clinic, and increasingly in drug discovery and development. In pretargeted PET imaging, the targeting moiety, such as an antibody or a nanoparticle, is first let to localize and bind to its target and any excess is allowed to clear from the body before radiolabe...

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Public examination: 5.10.2018

Queer Politics of Memory - Undisciplined Sexualities as Glimpses and Fragments in Finnish and Estonian Pasts

Riikka Taavetti

This study analyses the construction of queer and undisciplined sexualities in Finnish and Estonian personal and cultural memories from the 1990s to the present. The study makes a theoretical contribution to the understanding of queer as historical and localised concept by focusing on geographical areas regarded as the semiperiphery, that is, Finland and Estonia, and combining the discus...

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Public examination: 5.10.2018

INVOLUNTARY MUSICAL IMAGERY – EVERYDAY BUT EPHEMERAL

Lassi Liikkanen

Involuntary musical imagery (INMI) refers to a conscious experience of music that is unbidden by the subject. Often this experience consists of the repetition of a short musical fragment of melodic, popular music. This dissertation focuses on INMI, which emerged as a research topic in the early 2000s among a small community of general and music psychologists, neuroscientists and musicolo...

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Public examination: 5.10.2018

Novel Biomarkers in Metastatic Renal Cell Carcinoma

Patrick Penttilä

During the past decade, basic and translational cancer research has provided new information regarding the mechanisms underlying tumor growth, proliferation, and metastasis in renal cell carcinoma (RCC). Understanding of the molecular pathogenesis of RCC has identified new targets for therapeutic intervention. Angiogenesis, involving complex signaling pathways such as vascular endothel...

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Public examination: 5.10.2018

Seed quality attributes in seedling production of Norway spruce (Picea abies (L.) Karst.)

Katri Himanen

The artificial regeneration of Norway spruce (Picea abies (L.) Karst.) in the Nordic countries relies on planting containerized seedlings originating from seeds collected from either seed orchards or forest stands. The aim of this thesis is to investigate the effect of seed quality attributes on seedling production and to study whether it is possible to enhance germinability and seedling...

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Public examination: 5.10.2018

Contributions to the theory of multiplicative chaos

Janne Junnila

This thesis discusses various aspects of multiplicative chaos of log-correlated fields. It consists of an introduction and three papers. The introduction contains an overview of multiplicative chaos in general and is written in a somewhat pedagogical style. In addition, it highlights some of the results that appear in the three research articles. Topics that are discussed include distrib...

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Public examination: 6.10.2018

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AGGREGAATTORIT ÄÄNITTEIDEN DIGITAALISESSA JAKELUSSA Tekijänoikeuslainsäädännön ja verotuksen näkökulmasta

Laine, Annina / 27.04.2017

AGGREGAATTORIT ÄÄNITTEIDEN DIGITAALISESSA JAKELUSSA Tekijänoikeuslainsäädännön ja verotuksen näkökulmasta Laine, Annina Tiivistelmä/Referat – Abstract Internet ja digitaalitekniikan kehitys on mullistanut musiikkialaa merkittävästi ja huomattava osa äänitteistä siirtyy nykyään kuuntelijalle digitaalisessa muodossa. Kuluttajille äänitemarkkinoiden digitalisoituminen merkitsee, että mus...

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Kartellivahingon määrän todistaminen vahingonkorvausoikeudenkäynnissä

Korhonen, Sofie / 27.04.2017

Kartellivahingon määrän todistaminen vahingonkorvausoikeudenkäynnissä Korhonen, Sofie Tiedekunta/Osasto Fakultet/Sektion – Faculty Oikeustieteellinen tiedekunta Laitos/Institution– Department Tekijä/Författare – Author Sofie Korhonen Työn nimi / Arbetets titel – Title Kartellivahingon määrän todistaminen vahingonkorvausoikeudenkäynnissä Oppiaine /Läroämne – Subject Oikeustalo...

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The Patent Economics of Synthetic Biology

Bützow, Alexander / 27.04.2017

The Patent Economics of Synthetic Biology Bützow, Alexander Kyseinen työ tutkii uutta bioteknologian muotoa, synteettistä biologiaa, ja sen suhdetta eurooppalaiseen immateriaalioikeuteen, erityisesti patenttioikeuteen. Tutkielman keskeiset kysymykset koskevat sen selvittämisestä, onko 1) synteettisen biologian keksinnöt systeemisesti soveltumattomia nykyiseen patenttioikeuteen, ja 2...

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Vastuun rajoittaminen asianajotoimeksiantosopimukseen perustuvan vastuunhallinnan keinona

Sotamaa, Rasmus / 27.04.2017

Vastuun rajoittaminen asianajotoimeksiantosopimukseen perustuvan vastuunhallinnan keinona Sotamaa, Rasmus Asianajajan mahdollisuuksiin rajata vastuutaan on perinteisesti suhtauduttu varovaisen torjuvasti niin Suomessa kuin muissakin Pohjoismaissa. Torjuvan suhtautumisen perusteet on usein liitetty asianajotoiminnan erityiseen luonteeseen. Vastuunrajoitukset on nähty erityisesti asianaja...

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