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Effects of postmenopausal hot flushes and hormone therapy on quality of life and cardiovascular autonomic function

Hanna Hautamäki

Hot flushes, the most characteristic symptoms in menopause, are encountered by c.a. 80% of women. Hot flushes and other menopausal complaints can significantly impair a woman s quality of life. Additionally, the majority of women experience premenstrual symptoms in their fertile age. Due to the resemblance between premenstrual and menopausal symptoms, women with severe premenstrual sympt...

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Public examination: 21.11.2014

Diagnosis and Treatment of Pseudomyxoma Peritonei

Petrus Järvinen

Pseudomyxoma peritonei (PMP) is best treated by surgery. It was formerly treated by serial debulking. The current gold standard is complete cytoreductive surgery (CRS) to be followed by hyperthermic intraperitoneal chemotherapy (HIPEC). Improved survival figures for patients treated by CRS and HIPEC combined have been reported recently. The aim of this PhD research was to evaluate (I) th...

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Public examination: 21.11.2014

Proteomic profiling of an opportunistic human and animal pathogen Staphylococcus epidermidis

Pia Siljamäki

Staphylococcus epidermidis (SE) is an opportunistic pathogen capable of infecting humans and animals. It is a frequent cause of hospital-acquired infections in humans and of intramammary infections (IMIs) in dairy cows. The protein expression profiles and the genomes of three SE strains, one associated with bovine mastitis (PM221), one representing a commensal/low-virulent human strain (...

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Public examination: 21.11.2014

Assessment of TNFα blocking therapy in inflammatory bowel disease patients in deep remission

Pauliina Molander

In the era of TNFα-blocking therapy, MH and even DR have been suggested as new therapeutic targets in both CD and UC. Recent studies have indicated that DR may be achieved in roughly half of IBD patients on TNFα-blocking maintenance therapy, resulting in more favorable treatment outcomes. However, considering the potential side-effects and economic issues associated with long-term immuno...

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Public examination: 21.11.2014

Hemodynamic Collapse after Coronary Artery Bypass Grafting

Janne Karhunen

Sudden hemodynamic collapse after coronary artery bypass surgery is a major complication associated with high mortality and morbidity. There are many well-established risk stratification systems to assess the risk of mortality and morbidity after cardiac surgery. These risk scores, however, do not predict severe immediate postoperative complications such as sudden hemodynamic collapse.

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Public examination: 21.11.2014

Activation of innate immune responses by non-pathogenic and pathogenic bacteria in human leukocytes

Sinikka Latvala

The human body is continuously interacting with microbes. Cells of the immune system protect the host from microbes some of which can occasionally cause diseases. Macrophages and dendritic cells (DC) play a central role in innate and adaptive immune responses and they are activated in response to microbial stimulation. During activation these cells produce cytokines, soluble mediators th...

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Public examination: 21.11.2014

Regulation of leukocyte integrin binding to Ig-family ligands

Liisa Uotila

The adhesion molecules of blood cells are of great importance in the regulation of many of the most central processes of the human body, e.g. haematopoiesis, immune functions, haemostasis and wound healing, and the delivery of oxygen to the tissues. Leukocyte β2 integrins, VLA-4 integrin and members of the immunoglobulin superfamily like ICAMs (intercellular adhesion molecules) and VCAM ...

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Public examination: 21.11.2014

The Still Lifes of Edwaert Collier (1642-1708)

Minna Tuominen

Among seventeenth-century Dutch still life painters Edwaert Collier is best known for his vanitas paintings. He also painted a considerable number of trompe l oeils. These paintings constitute the primary material for my thesis, along with the biographical records from Breda, Haarlem, Leiden, Amsterdam and London, all places where Collier lived. This research is an examination of the var...

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Public examination: 21.11.2014

Functional surfaces and nanoparticles based on semifluorinated copolymers

Lauri Valtola

The main objectives of the present research were the synthesis and characterization of organosoluble semifluorinated copolymers from various monomers. Polymers were synthesized either by free radical solution polymerization yielding random copolymers or by atom transfer radical polymerization to build up block structures.

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Public examination: 21.11.2014

Anticipatory look-ahead fixations in real curve driving

Esko Lehtonen

In the visual control of locomotion, gaze is used to sample information in an anticipatory manner. In car driving, this anticipation functions at both a short and long time distance. At the short time distance, gaze leads the locomotion with a small (1‒3 s) time headway. Many steering models have explained this behavior by interpreting that drivers track a steering point on the road to o...

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Public examination: 21.11.2014

Host-pathogen coevolution through trade-offs and coinfection

Hanna Susi

At the very core of the evolution of living organisms lie interactions with other species. Between two coevolving species, a change in one species may generate selection for a change in the other species. In host-pathogen coevolution the central dilemma is to understand how infectivity and virulence evolve. Infectivity is the ability to infect a given host while virulence is the harm the...

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Public examination: 21.11.2014

Image processing methods for limited angle tomography and sparse angle tomography

Martti Kalke

The purpose of this thesis was two-fold: Firstly, to evaluate if limited angle tomography is suitable for clinical implant planning. Secondly, to improve clinical image quality and workflow of the limited angle tomography by developing new imaging processing algorithms.

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Public examination: 21.11.2014

A novel pre-treatment for cheese production: Biochemistry, sensory perception and consumer acceptance

Kevin Cárthaigh Deegan

Homogenisation is a physical process which results in the reduction in the size of fat-globules to reduce creaming. It is not generally used in cheesemaking as it allows access of the indigenous enzyme lipoprotein lipase (LPL) to the triacylglycerol core of the fat globule, resulting in uncontrollable lipolysis and rancidity both in the milk and cheese made therefrom. It was hypothesised...

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Public examination: 22.11.2014

The Lopnor dialect of Uyghur - A descriptive analysis

Esmael Abdurehim

In this corpus-based study, I have developed a comprehensive grammatical description of the Lopnor dialect of Uyghur, which is an endangered Turkic variety spoken in the northwestern part of China. This dissertation consists of a description of the phonology, morphology and syntax of the Lopnor dialect.

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Public examination: 24.11.2014

Collaborative Mobile Energy Awareness

Eemil Lagerspetz

We have created a mobile energy measurement application and gathered energy measurement data from over 725,000 devices, running over 300,000 applications, in heterogeneous environments, and constructed models of what is normal in each context for each application. We have used this data to find energy abnormalities in the wild, and provide users of our application advice on how to deal w...

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Public examination: 24.11.2014

Traceability for nanometre scale measurements : Atomic force microscopes in dimensional nanometrology

Virpi Korpelainen

Reliability of measurement is a crucial element of both research and industry. Metrological traceability to the SI unit metre guarantees commensurate units, also at nanometre range. In this thesis, a traceability chain is established for nanometre scale measurements. Measurement instruments and methods were developed for accurate measurements, calibration of instruments and transfer stan...

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Public examination: 26.11.2014

CHARACTERIZATION OF NEUROTOXIN GENE LOCATION, TOXIGENESIS AND COLD TOLERANCE IN CLOSTRIDIUM BOTULINUM

Zhen Zhang

Clostridium botulinum is an infamous pathogen that produces botulinum neurotoxin, the causative agent of potentially fatal, neuroparalytic disease in humans and animals called botulism. Despite decades of research, much remains unknown regarding neurotoxin gene location, toxigenesis, and physiology of C. botulinum. First, it is unclear whether mobile genetic elements can mediate transmis...

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Public examination: 28.11.2014

Psychiatric symptoms in vertigo patients

Sirpa Ketola

Vertigo and dizziness are among the most frequent complaints in primary care. The symptoms are usually self-limited, and the clinical course is benign, with full recovery. In many cases, however, vertigo and dizzy spells recur, leading to impairment and chronic outcome. A number of studies have documented a high prevalence of psychiatric comorbidity in vertiginous patients. Vertigo and d...

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Public examination: 28.11.2014

The healthy Nordic diet, obesity and obesity-related metabolic risk factors

Noora Kanerva

Obesity causes metabolic dysregulations that increase the risk of cardiovascular disease (CVD) and type 2 diabetes (T2D). Diet is known to play a key role in preventing obesity. In epidemiological studies, because single food and nutrient studies focusing on obesity have produced generally inconsistent results, nutrition researchers have shifted to exploring the health related effects of...

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Public examination: 28.11.2014

Tall oil fatty acid-based alkyd-acrylic copolymers: Synthesis, characterization, and utilization in surface coating applications

Pirita Rämänen

Due to increased awareness of environmental issues and tightened legislation, bio-based substitutes for traditional petroleum-based polymers are being increasingly sought. Tall oil fatty acid (TOFA) is an attractive material for that purpose being a by-product of kraft pulping. Thus, it is abundant year-round, the price is reasonable, and it does not compete with foodstuff materials. In ...

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Public examination: 28.11.2014

Neuro-cognitive factors contributing to paranormal beliefs: core knowledge violations, cognitive inhibition, and the social brain

Tapani Riekki

The present thesis consists of six studies that investigate different cognitive factors that contribute to believing and unbelieving in paranormal, superstitious, magical, and supernatural (commonly referred to as paranormal beliefs). Earlier studies have found several factors reaching from personality factors to cognitive factors to cultural factors that contribute to believing. However...

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Public examination: 28.11.2014

VALUES, FAIRNESS AND LEGITIMACY : IN THE CONTEXT OF FINNISH FOREST AND NATURE CONSERVATION POLICY

Annukka Valkeapää

This study focuses on the values, fairness, and legitimacy of forest-related decision-making in Finland. This context can be described with the opposing values of the intensive use of forests and biodiversity conservation. Further, the legitimacy of decision-making processes in the field has been questioned by various stakeholder groups. The purpose of forest policy in Finland is to enha...

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Public examination: 28.11.2014

Antiangiogenic and proteolytic activities of prostate-specific antigen

Johanna Mattsson

Prostate-specific antigen (PSA) is a very useful biomarker for prostate cancer. The PSA concentration in circulation increases due to leakage of PSA from cancerous tissue. Normally PSA, a serine protease with chymotrypsin-like enzymatic activity, is secreted into seminal fluid by the epithelial cells of the prostate. The major physiological function of PSA in seminal fluid is to digest s...

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Public examination: 28.11.2014

Epidemiology and clinical associations of human parechovirus and Ljungan virus

Pekka Kolehmainen

Human parechovirus (HPeV) and Ljungan virus (LV) are non-enveloped, single-stranded RNA viruses that form the genus Parechovirus in the family Picornaviridae. The interest in these viruses has notably increased over the past 15 years because of their strengthened associations to human and animal diseases. HPeV types 1 and 3 have been associated with more severe infections in young childr...

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Public examination: 28.11.2014

Adhesion and Survival Tools of the Bacterium Deinococcus geothermalis

Christina Liedert

The known natural habitats of Deinococcus geothermalis are geothermal springs and deep ocean subsurfaces. The bacterium has also found its way to manmade environments, including paper machines and drinking water distribution systems, from which it is very difficult to remove due to its resistance towards industrial washing procedures, dehydration and even high doses of ionizing radiation...

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Public examination: 28.11.2014

Molecular mechanisms regulating glucose uptake into podocytes: Role of ezrin, septin 7 and nonmuscle myosin IIA

Anita Wasik

Diabetic nephropathy (DN) is a major microvascular complication of diabetes and a common cause of end-stage renal disease. Mechanisms leading to the development of DN are not fully understood, but podocyte injury is involved. Interestingly, in respect to glucose uptake podocytes are uniquely insulin sensitive cells. Insulin rapidly induces remodeling of the actin cytoskeleton and leads t...

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Public examination: 28.11.2014

Proportionality and Best Interests:Calibrating the Twin Pillars of Child Justice in Nigeria

Uchenna Emelonye

This thesis adopted the law in context methodology after due consideration of other legal research methodologies. To situate child justice within the parameters of child rights, this thesis analyzed the normative underpinning of child rights and found that its foundation is traceable to the International Bill of Human Rights. It also examined the philosophical foundations of child rights...

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Public examination: 28.11.2014

Perspectives on Mobility and Travelling : A study of references to functionally-bound forms of individual movement in non-literary texts from New Kingdom Deir el-Medina

Patricia Berg

Throughout history, people have moved between places. One approach of studying the relationship between people and the environment they live within is called a phenomenology of landscape. According to this approach, all landscapes are embedded in the social and individual times of memory and there is a right way to move around in the familiar landscape. In this dissertation I present tex...

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Public examination: 28.11.2014

On spectrum of the linear water-wave problem in cuspidal domains

Jussi Martin

In this thesis we study the spectrum of a certain boundary value problem in cuspidal domains. This boundary value problem originates from the linear theory of water-waves. One particular motivation for studying the problem in cuspidal domains, is that in some cases the cuspidal shape could act as a wave absorbing structure. Furthermore, the problem itself has also mathematical interest o...

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Public examination: 28.11.2014

New insights into enhancing morphine analgesia: from glia to pharmacokinetics

Tuomas Lilius

Opioid analgesics are effective in relieving acute and chronic pain. However, adverse effects and the development of opioid dependence and tolerance may restrict the use of opioids and result in inadequate pain relief. The effects of four structurally and functionally different drugs already on the market, ibudilast, atipamezole, spironolactone, and ketamine, were studied in coadministra...

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Public examination: 28.11.2014

”Uinuvat metsävaramme käytön piiriin” : Valtionmetsien käytön suuri murros 1939-1970

Antti Parpola

The use of Finland s national forests changed with World War II. During the 1940s and 1950s, the total cut tripled in relation to the area managed for timber production, and the area clear-cut increased six-fold. These new intensive logging practices became standard in the remote forests of eastern and northern Finland. This study explains how and why the agency governing the Finnish nat...

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Public examination: 29.11.2014

Pragmatische Phraseologismen und ihre lexikografische Darstellung : Am Beispiel eines mehrsprachigen elektronischen Spezialwörterbuches für Übersetzer

Anna Ruusila

This work integrates the research of phraseology, lexicography, and translation. The study is primarily concerned with a specific type of phraseologisms called pragmatic phraseologisms that are first and foremost pragmatically fixed. Pragmatic phraseologisms can be divided into two groups: routine formulae and conversational formulae. Both of them have numerous functions in different com...

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Public examination: 29.11.2014

How do teachers benefit from training on social interaction skills? : Developing and utilising an instrument for the evaluation of teachers social and emotional learning

Markus Talvio

By using their social interaction skills, teachers create an autonomous and supportive climate in the classroom. Research, however, is scarce on how teachers can develop these skills despite being emphasised as key tools in modern learning psychology. This intervention study explored the development of teachers social and emotional learning (SEL) skills during Gordon s Teacher Effectiven...

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Public examination: 29.11.2014

Maternal hypertensive disorders during pregnancy and the mental health and cognitive functioning of the adult offspring: the Helsinki Birth Cohort Study

Soile Tuovinen

Hypertensive pregnancy disorders complicate approximately 10% of all pregnancies. They may compromise placental functioning and, thus, affect the fetal developmental milieu. It is therefore highly plausible that they have consequences for the developmental outcomes of the offspring. However, their role in the developmental plasticity phenomenon dubbed programming remains relatively unexp...

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Public examination: 29.11.2014

Työn mieltä etsimässä : Työhyvinvoinnin edistäminen ammatinopettajien työssä

Annarita Koli

This dissertation concerns work-related well-being of vocational teachers and the possibilities for well-being promotion in changing work activity. Previous studies concerning teachers’ occupational well-being and change have focused either on individual teachers as recipients of change, or on the characteristics and reforms of teaching work on a general level. Only rarely has work-relat...

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Public examination: 29.11.2014

The Artifact Project. Promoting Design Learning in the Elementary Classroom

Kaiju Kangas

Designing, from its very premise, aims to create something new. Therefore, it can be seen as a form of object-oriented process of knowledge-creation, which, in turn, is considered a fundamental future competence. In order to productively participate in the future society, students need experience of creative knowledge work practices from an early stage of their education. Since the objec...

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Public examination: 29.11.2014

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Eräiden biopolttoainesovelluksiin käyttökelpoisten mikroleväkantojen fotosynteesin valo- ja lämpötilavasteet

Nieminen, Martta / 21.11.2014

Eräiden biopolttoainesovelluksiin käyttökelpoisten mikroleväkantojen fotosynteesin valo- ja lämpötilavasteet Nieminen, Martta Niin Euroopan unionin kuin kansainvälisenkin energiapolitiikan päämääränä on viime vuosina ollut lisätä uusiutuvien polttoaineiden osuutta kokonaiskulutuksesta. Syinä trendiin ovat hupenevat fossiiliset polttoainevarannot ja kansakuntien pyrkimys energiaomavaraisu...

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Hur påverkar tidigare graviditetsdiabetes och levnadsvanorna fertiliteten?

Björkstrand, Julia Maria / 20.11.2014

Hur påverkar tidigare graviditetsdiabetes och levnadsvanorna fertiliteten? Björkstrand, Julia Maria Målet för avhandlingen är att undersöka sambandet mellan graviditetsdiabetes (GDM) och sekundär infertilitet, samt levnadsvanor som kan öka risken för sekundär infertilitet. Undersökningen gjordes på ett material som insamlats för The Finnish Gestational Diabetes Prevention Study (RADIEL),...

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Ukraina ja Putinin Venäjä: Kremlin turvallisuuspalvelutaustaisen eliitin reaktio Ukrainan vuoden 2004 oranssiin vallankumoukseen

Koskinen, Aleksi / 21.11.2014

Ukraina ja Putinin Venäjä: Kremlin turvallisuuspalvelutaustaisen eliitin reaktio Ukrainan vuoden 2004 oranssiin vallankumoukseen Koskinen, Aleksi Yleisen historian pro gradu -tutkielma: Helsingin yliopisto, filosofian, historian, kulttuurin ja taiteiden tutkimuksen laitos, 2014.

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Vanhempien osallisuuden elementtejä suomalaisen varhaiskasvatuksen kontekstissa

Tanneraho, Maija / 20.11.2014

Vanhempien osallisuuden elementtejä suomalaisen varhaiskasvatuksen kontekstissa; Elements of parent involvement in the context of Finnish early childhood education Tanneraho, Maija Tutkimuksen tarkoituksena on tuoda esille vanhempien osallisuuden elementit, joita suoma-laisen varhaiskasvatuksen kontekstista löytyy varhaiskasvattajien kokemusten ja näkemys-ten pohjalta. Tutkimuksen viitek...

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