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Dietary fatty acids and vitamin D during early life and the risk of type 1 diabetes

Sari Niinistö

The aim of the present study was to evaluate the associations between the maternal intakes of fatty acids, vitamin D, and their respective dietary sources during pregnancy or lactation, as well as the child s fatty acid status, and the risk of type 1 diabetes. The present study is a prospective cohort belonging to the nutrition part of the Finnish Type 1 Diabetes Prediction and Preventio...

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Public examination: 17.12.2014

Early mathematics interventions - Supporting young children with low performance in mathematics

Riikka Mononen

The purpose of this thesis was to investigate the effectiveness of early mathematics interventions for young children with low performance in mathematics. Previous research has indicated that early mathematics skills are a strong predictor of later mathematics performance. The goal of early mathematics support by means of interventions is to improve mathematics performance, and consequen...

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Public examination: 17.12.2014

TGF-β family signaling in the regulation of cell plasticity in lung cells and mesothelioma

Jenni Tamminen

The aim of this thesis was to extend the understanding of molecular mechanisms of asbestos exposure related diseases asbestosis (lung fibrosis), lung cancer and mesothelioma. Epithelial-to-mesenchymal transition (EMT) is implicated in fibrosis and in cancer, both asbestos induced diseases. The first of the three studies investigated whether asbestos fibers induced EMT. In the next two st...

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Public examination: 19.12.2014

Inverse boundary problems involving the magnetic Schrödinger operator

Valter Pohjola

This thesis deals with various aspects of the inverse boundary value problem for the magnetic Schrödinger operator. The first paper extends earlier uniqueness results to the case where the domain is a half space. The two main features of this problem is that the domain is not a bounded set and that the DN-maps are known only on parts of the boundary. The results in this paper extend know...

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Public examination: 19.12.2014

Joseph Sittler and Early Ecotheology

Panu Pihkala

This study analyzes early twentieth-century ecotheology about which it provides a great deal of new information. The focal point is the work of Joseph Sittler (1904 1987), an American Lutheran and ecumenical theologian. Through the use of systematic analysis and historical methods, Sittler s thought is placed in context in relation to other early ecotheology and environmentalism. Many st...

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Public examination: 19.12.2014

Prognostic Models in Traumatic Brain Injury

Rahul Raj

Background: Prognostic models are important tools for heterogeneity adjustment in traumatic brain injury (TBI). Prognoses after TBI have been particularly challenging to predict, with limited availability of robust prognostic models. TBI patients are by definition trauma patients, and often treated in the intensive care unit (ICU). Several prognostic models for ICU and trauma patients ha...

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Public examination: 19.12.2014

Kirjoitelma ja tekijän ääni : Kehystämisen yhdyslauseet suomenkielisen ylioppilasaineen dialogisuuden hallinnassa

Riitta Juvonen

The study examines framing (or projecting) clause complexes in Finnish-language matriculation essays from the point of view of the intersubjective positioning of the writer. The clause complexes investigated comprise of a matrix clause and its complement, mainly an että that or a kuinka/miten how clause. The starting point for the analysis is the assumption that the matrix clause express...

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Public examination: 19.12.2014

Oral and nutritional problems among residents in assisted living facilities

Riitta Saarela

This study formed part of a developmental project in the Helsinki Metropolitan Area of Finland during 2003 2011 that aimed to develop nutritional care in long-term care facilities. The aim of this study was to assess tooth brushing/denture cleaning habits, dentition, chewing problems, and swallowing difficulties and their associations with nutritional status and eating habits. Furthermor...

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Public examination: 19.12.2014

Systematizing morphology: a total evidence approach to ditrysian phylogenetics (Lepidoptera)

Maria Heikkilä

Lepidoptera (butterflies and moths) are one of the most diverse and species-rich groups of organisms. Currently, the number of described species is close to 160.000, but it is estimated that the true number of species could be as high as half a million. Nearly 99% of all Lepidoptera belong to the more advanced subclade Ditrysia. The focus of this thesis is the evolutionary history of the...

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Public examination: 19.12.2014

Role of 3'UTR in the regulation of neurotrophic factors BDNF and GDNF

Anmol Kumar

Neurotrophic factors such as brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) are a family of proteins which play an important role inside and outside central nervous system. While precise regulation of BDNF and GDNF levels in time and space in an organism is crucial in determining the biological outcome, mechanisms involved in controlling t...

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Public examination: 19.12.2014

Structural studies of O-acetylglucuronoxylans and their modifications in plant cell walls

Sun-Li Chong

O-acetylglucuronoxylans (AcGX) are the major hemicelluloses found in the secondary cell wall of dicotyledon species. The backbone is formed by β(1→4)-linked xylopyranosyl (Xylp) residues, which are substituted by α(1→2)-linked (4-O-methyl)glucopyranosyluronic acid ((Me)GlcpA). The AcGX are also highly acetylated on the 2-O or 3-O; or both positions of Xylp units. Notably, acetylation pat...

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Public examination: 19.12.2014

Activation of innate immune response in human macrophages by Herpes simplex virus-1 and crystallized monosodium urate

Juho Miettinen

Innate immunity provides the first line of defence against invading pathogens, and can also be activated by endogenous danger signals released upon tissue damage or injury. Macrophages play an important role in innate immunity. They perform the immune surveillance of their immediate surroundings seeking out tissue damage and/or invading pathogens via pattern recognition receptors. Macrop...

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Public examination: 19.12.2014

Evolution in salt: Genomic and structural approaches to halophilic archaea and their viruses

Salla Jaakkola

Extremely saline environments include salt lakes, evaporation ponds, and terrestrial environments, such as salt deserts and underground halite deposits. They are inhabited by halophilic microbes that require salt for living. Cell densities in hypersaline waters can be as high as 107-108 cfu/ml, and most of the cells are archaeal. The number of viruses can be ten times higher than that of...

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Public examination: 19.12.2014

Studies on Earnings Dynamics and Uncertainty in Return to Education

Otto Kässi

This thesis studies earnings differences and their dynamics empirically. It consists of an introductory chapter and three independent research papers. All of the three papers are done using Finnish registry data. Chapter two studies the evolution of income inequality from the end of 1980s until the year 2007. I present a statistical decomposition method, which is used to decompose earnin...

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Public examination: 19.12.2014

Physical activity, nutrition and stress response in young adults born preterm − determinants of health and disease : The Helsinki Study of Very Low Birth Weight Adults

Nina Kaseva

Advancements in neonatal care are resulting in increasing numbers of adult survivors after preterm birth at very low birth weight (VLBW, ≤ 1500 g). VLBW is associated with risk factors of non-communicable diseases, e.g. cardiovascular disease, osteoporosis and diabetes. We investigated mechanisms underlying the effects of preterm birth on later health in VLBW adults, with a focus on 1) p...

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Public examination: 19.12.2014

RARE GENOMIC DELETIONS UNDERLYING SCHIZOPHRENIA AND RELATED NEURODEVELOPMENTAL DISORDERS

Olli Pietiläinen

Severe mental disorders including schizophrenia often segregate within the same families. Twin and family studies suggest that this co-occurrence is largely genetic, which implies that the different mental disorders have a shared genetic background. Some symptomatic features, such as cognitive impairment also manifest to a variable degree in the majority of severe mental disorders. Cogni...

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Public examination: 19.12.2014

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Distribution of melanin binding drugs – A kinetic study with pigmented and albino rats using SPECT/CT imaging method

Nurmi, Satu / 16.12.2014

Distribution of melanin binding drugs – A kinetic study with pigmented and albino rats using SPECT/CT imaging method Nurmi, Satu Many drugs are known to bind to melanin, a complex pigment polymer found in several human tissues. Melanin can act as a natural depot by prolonging the effect of the drug and reducing its toxicity. Since it is highly concentrated in the posterior part of the ey...

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The effect of different light spectra on berry callus pigment accumulation, lipid composition and secondary metabolism

Åman, Olli / 16.12.2014

The effect of different light spectra on berry callus pigment accumulation, lipid composition and secondary metabolism Åman, Olli Plant cells in plant cell cultures can be used for production of secondary metabolites and recombinant proteins. Producing the desired compounds can be problematic since cells grow slowly, yields can be low and sometimes plant cells do not produce the desired ...

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Neptunium sorption on corundum, montmorillonite and bentonite colloids

Elo, Outi / 16.12.2014

Neptunium sorption on corundum, montmorillonite and bentonite colloids Elo, Outi The largest amount of actinides possibly to be released into the environment, however, can be attributed to the geological disposal of spent nuclear fuel. Neptunium is more environmentally mobile than other transuranic elements and thus could escape into the environment. The long-lived neptunium isotope Np-2...

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Den deltagande demokratins ideal och praktik : En fallstudie i deltagande budgetering vid Helsingfors Ungdomscentral

Boldt, Georg / 17.12.2014

Den deltagande demokratins ideal och praktik : En fallstudie i deltagande budgetering vid Helsingfors Ungdomscentral Boldt, Georg Denna avhandling behandlar medborgardelaktighet i offentliga beslutsprocesser och framförallt de faktorer som måste uppfyllas för att deltagandet skall upplevas som meningsfullt. Avhandlingen är utförd som en fallstudie i Helsingfors stads Ungdomscentrals pil...

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