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Alkaloids of in vitro cultures of Rhazya stricta

Amir Akhgari

Rhazya stricta Decne. (Apocynaceae) is a traditional medicinal plant in the Middle East and South Asia. It produces a large number of terpenoid indole alkaloids(TIAs), some of which possess important pharmacological properties. This study focused on the establishment of biotechnological production tools of R. stricta, namely undifferentiated cell cultures, and an Agrobacterium rhizogenes...

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Public examination: 29.5.2015

Anthropometric measurements of obesity in relation to mortality and cancer incidence among European adults

Xin Song

Background and aims: Obesity has become the sixth most important risk factor contributing to the overall burden of a variety of diseases worldwide. The association of anthropometric measures of obesity with mortality from various causes and incidence of cancers of various sites has been investigated, but it remains controversial. The aims of this study were to: 1) evaluate the epidemiolo...

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Public examination: 29.5.2015

Calcium A Key Player In Early Neural Development And Migration: TRPCs and VGCCs

Lauri Louhivuori

Signaling pathways linked to changes in the intracellular cytosolic concentrations of free calcium are involved in a plethora of cellular activities ranging from cell division, differentiation and migration, integration of neural circuits, as well as programmed neuronal cell death. Channels that permit the entrance of calcium into neuronal cells have gathered considerable interest due to...

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Public examination: 29.5.2015

Developing a physiotherapeutic testing battery for dogs with stifle dysfunction

Heli Hyytiäinen

Stifle dysfunction is one of the most common reasons for canine hindlimb lameness and an indication for dogs referral to physiotherapy. Until now, there has been a lack of testing batteries in animal physiotherapy, although these are an important part of the evaluation process in various patient groups in human physiotherapy.

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Public examination: 29.5.2015

The long-term outcome of frozen shoulder

Heidi Vastamäki

The purpose of the current study was to assess and report the long-term outcome of frozen shoulder. The 234 patients with 257 frozen shoulders were clinically followed up for a mean 9.7 years (range, 2-30). The study includes five peer-reviewed articles. The specific aims of this project were to study: 1) the long-term outcome of the natural course of idiopathic frozen shoulder, 2) the v...

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Public examination: 29.5.2015

Efficacy, Safety and Clinical Outcomes of Biologic Drugs in the Treatment of Rheumatoid Arthritis

Kalle Aaltonen

Rheumatoid Arthritis (RA) is an autoimmune disease, which is treated with anti-inflammatory and immunosuppressive medication comprising synthetic disease-modifying anti-rheumatic (sDMARDs) and biologic drugs. In this thesis all published randomized controlled trials studying the efficacy and safety of biologic drugs based on the inhibition of tumor necrosis factor (TNF) were identified, ...

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Public examination: 29.5.2015

Candidate therapeutic targets against acute myeloid leukemia identified via screening combinatorial peptide and chemical libraries

Katja Karjalainen

Acute myeloid leukemia (AML), although rare, is highly malignant neoplasms that account for a majority of leukemia-associated deaths. AML results from an over-growth of immature myeloid cells in the bone marrow. These cells are functionally abnormal and interfere with the production of normal hematopoietic cells. Despite apparent phenotypic uniformity, AML is a heterogeneous group of mye...

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Public examination: 29.5.2015

TUMOUR GLYCOSYLATION AND GLYCOPROTEINS AS BIOMARKERS IN COLORECTAL CANCER

Tuomas Kaprio

Colorectal cancer (CRC) is one of the world s three most common cancers, and its incidence is rising. Novel biomarkers are essential for diagnostic and prognostic tools and to identify patients for targeted and individualized therapy. Covering all human cells, the carbohydrate units of glycoproteins, glycolipids, and proteoglycans are glycans. Carcinoma-related glycan structures are pote...

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Public examination: 29.5.2015

Natural stimuli and experimental setups in the study of the neural basis of social interaction

Lotta Hirvenkari

Social interaction consists of events of different modalities that unfold on a subsecond timescale and are usually influenced by all involved participants. Therefore, social interaction is difficult to be simulated in laboratory, as simple, static, and unidirectional stimuli and tasks do not cover its properties accurately enough. However, moving towards more natural experimental setups ...

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Public examination: 29.5.2015

Ice formation, growth and associated substrate supply determine sea-ice bacterial community dynamics

Eeva Eronen-Rasimus

Sea ice, at its maximum extent, is one of the largest biomes on Earth. In addition to the polar oceans, it covers extensive sea areas at lower latitudes such as the Baltic Sea and the Sea of Okhotsk. During ice formation, organic and inorganic components in the parent seawater are concentrated into saline brines within the ice, which serve as a habitat for diverse auto- and heterotrophic...

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Public examination: 29.5.2015

DIAGNOSIS AND TREATMENT OF PREMALIGNANT CHANGES OF PHOTODAMAGED SKIN: Novel Hyperspectral Imaging and New Therapeutical Aspects

Noora Neittaanmäki-Perttu

ABSTRACT Background and purpose: As the skin cancer burden continues to increase, there is an urgent need for novel methods for the early detection of skin cancers, and for new cost-effective treatments. The hyperspectral imaging system (HIS) is a novel technique which offers the dual advantages of allowing the imaging of large skin areas rapidly and non-invasively. Daylight photodynamic...

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Public examination: 29.5.2015

Temporal and spatial turnover of freshwater diatoms - Implications for bioassessment

Laura Virtanen

Water quality in streams usually changes fast, and sensitive biological indicators are essential for monitoring these changes. Diatoms are widely used in biological stream quality assessments. However, there are temporal and spatial variations in diatom communities that may result in unreliable quality assessments. Under different kinds of environmental stressors, diatoms can produce def...

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Public examination: 29.5.2015

HEALTHY INDIVIDUALS DECISION MAKING IN ONLINE POKER: PERSPECTIVES ON EMOTIONAL STABILITY AND WELLBEING

Michael Laakasuo

In our previous studies it has been found that a phenomenon labeled tilting is a form of moral anger. When players are in tilt they make a series of bad decisions, chase their losses and express anger by cursing their opponents. In the context of tilting, the players also report episodes of memory loss. Additionally, we also developed a scale that measures the level of a player's poker e...

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Public examination: 29.5.2015

Collaborative knowledge construction in the context of problem-based learning - Exploring learning from conflicting ideas and knowledge

Matti Aarnio

Today's medical education faces the challenge of developing students competencies to resolve ever more complex problems in collaboration with other professionals. Problem-based learning (PBL) has proven useful for developing many of the competencies needed in modern healthcare. In PBL students collaboratively construct knowledge to explain and solve problems related to real-life situatio...

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Public examination: 30.5.2015

Cell-based bioluminescent high-throughput screening methods in antibacterial drug discovery

Susanna Nybond

Due to the emergence of multidrug resistant bacteria, bacterial infections are still a major healthcare problem. Many factors have led to a discovery void of new antibacterial agents, rendering the current antibiotic pipeline inadequate for future medical needs. For example, the outcomes from pure biochemical high-throughput screening (HTS) assays have, in many cases, not led to successf...

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Public examination: 4.6.2015

Life cycle of a cloud condensation nucleus, CCN

Mikhail Paramonov

The research conducted and presented herein concentrates primarily on the life cycle of a cloud condensation nucleus CCN. The primary motivation of the work is the importance of CCN in the global aerosol-cloud-climate system, and focus is placed on the production of CCN, their behaviour in the atmosphere and their properties with respect to CCN activation, as well as the removal pathways...

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Public examination: 5.6.2015

Lake-atmosphere greenhouse gas exchange in relation to atmospheric forcing and lake biogeochemistry

Jouni Heiskanen

Greenhouse gas (GHG) emissions from lakes result from processes between the watershed, lake characteristics and the atmosphere. The organic matter loading from the watershed both provides carbon for the lake biota and in major part defines water clarity, which, in addition to wind and heat flux, is essential in thermocline formation. Thermal stratification suppresses the wind-induced mom...

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Public examination: 5.6.2015

Role of Gli3 during intramembranous calvarial bone development

Lotta Veistinen

The flat bones of the skull, the calvarial bones, develop by intramembranous ossification during which mesenchymal cells first condense and subsequently differentiate into osteoblasts. Sutures separate the calvarial bones and facilitate the synchronized growth of the underlying brain and the calvaria.

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Public examination: 5.6.2015

Matrix metalloproteinases and toll-like receptors in early-stage oral tongue squamous cell carcinoma

Laura K. Mäkinen

Predicting the clinical course of an early-stage oral tongue squamous cell carcinoma (OTSCC) is challenging, as even small tumors can behave aggressively. OTSCC often metastasizes to the cervical lymph nodes, and the presence of lymph node metastasis at the time of diagnosis is considered the most important tumor-related prognostic factor in OTSCC. The mechanisms of this disease progress...

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Public examination: 5.6.2015

The prediction of single-tree biomass, logging recoveries and quality attributes with laser scanning techniques

Ville Kankare

The precise knowledge of forest structural attributes play an essential role in decision-making, forest management procedure planning and in wood supply chain optimization. Laser scanning (LS) is one of the most promising remote sensing techniques, which can be used to estimate forest attributes at all levels, from single trees to global applications. The main objectives of the present t...

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Public examination: 5.6.2015

Fear of childbirth

Hanna Rouhe

Every 10th pregnant women suffers from severe fear of childbirth. It causes anxiety and physical symptoms during pregnancy, and may interfere with mother-infant bonding. Caesarean sections on maternal request are rising worldwide. The major indication is fear of childbirth. There is no clinical guideline regarding how to help these women. This present study was designed to investigate th...

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Public examination: 5.6.2015

Being a young activist in the late Mubarak era - An ethnography of political engagement in Egypt

Henri Onodera

This is an ethnographic study of the lived experiences of young activists during the last years of Mubarak s presidency in Egypt. Its general aim is to provide an understanding of what it was like to be involved in opposition politics during a period when the eventual end of Mubarak s rule in 2011 was little more than a collective aspiration. Drawing on different strands of qualitative s...

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Public examination: 5.6.2015

Hyvä koti ja henkinen äitiys lastentarhatyön esikuvina - Aate- ja käsitehistoriallinen tutkielma Suomen varhaiskasvatuksen taustasta

Maija Meretniemi

Tutkimus tarkastelee aate- ja käsitehistoriallisesti lastentarhanopettajien näkökulmasta suomalaisen lastentarhan johtavina periaatteina olleita käsitteitä " hyvä koti" ja "henkinen äitiys" aikakaudella noin 1890-1950. Keskeinen tutkimusongelma on yksityisen ja julkisen jännite lastentarhatoiminnan aatteellisissa lähtökohdissa, toiminnan tavoitteissa sekä lastentarhanopettajien itseymmär...

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Public examination: 6.6.2015

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I varje pärlas kärna finns en orenhet: Om historikern som profet och träldomens ofrånkomlighet i Fredrik Långs roman Mitt liv som Pythagoras

Köhler, Sebastian / 28.05.2015

I varje pärlas kärna finns en orenhet: Om historikern som profet och träldomens ofrånkomlighet i Fredrik Långs roman Mitt liv som Pythagoras Köhler, Sebastian Denna pro gradu-avhandling undersöker framför allt det historiska, men också det filosofiska i Fredrik Långs roman Mitt liv som Pythagoras (2005). Romanen är en fantasifull berättelse om den antika filosofen och matematikern Pythag...

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Numerical Modelling of Mid-Crustal Flow Applied to Svecofennian Orogeny

Lammi, Hannu / 26.05.2015

Numerical Modelling of Mid-Crustal Flow Applied to Svecofennian Orogeny Lammi, Hannu This work explores the lateral spreading of hot, thick, Paleoproterozoic crust via a series of 2D thermomechanical numerical models based on two geometrical a priori models of the thickened crust: plateau and plateau margin. High Paleoproterozoic radiogenic heat production is assumed. The material viscos...

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Rakennetun ympäristön esteettinen laatu ja kaupunkisuunnittelukulttuurin murros

Vihanninjoki, Vesa / 27.05.2015

Rakennetun ympäristön esteettinen laatu ja kaupunkisuunnittelukulttuurin murros Vihanninjoki, Vesa Tämä pro gradu -tutkielma käsittelee ympäristön esteettisyyden määrittelyä ja esteettisen ympäristön tuottamista suomalaisen kaupunkisuunnittelun kontekstissa. Tutkielmani teoreettinen perusta on filosofisessa estetiikassa erityisesti fenomenologisessa ympäristöestetiikassa mutta tutkie...

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Pohjaveden kloridipitoisuuksien muutokset ensimmäisen Salpausselän alueella

Lindroos, Nina / 26.05.2015

Pohjaveden kloridipitoisuuksien muutokset ensimmäisen Salpausselän alueella Lindroos, Nina Ensimmäisellä Salpausselällä esiintyy suuria, hyvälaatuisia pohjavesiesiintymiä, joilla on riski pilaantua tiesuolauksen vaikutuksesta. Tiesuolaa (natriumkloridia) on käytetty Suomessa teiden liukkaudentorjuntamenetelmänä 1950-luvulta alkaen. Tiesuolan kokonaiskäyttömäärä oli Suomessa suurimmillaan...

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