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Transcription Factors Foxi3 and Sox2 in the Regulation of Tooth Development

Maria Jussila

Teeth are ectodermal organs, which form from the embryonic epithelium and mesenchyme. Reciprocal interactions between these two tissues, regulated by the conserved signaling pathways, guide tooth morphogenesis. Activity of each signaling pathway is mediated by transcription factors, which activate or repress target genes of the pathway. During morphogenesis, the shape of the dental epith...

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Public examination: 22.8.2014

Functional Sequence Annotation in an Error-prone Environment

Patrik Koskinen

As more and more sequences are submitted to public databases, so will grow more computationally challenging sequence retrieval systems. When for example the UniProtKB/TrEMBL doubles in size annually, the tools used today might not be sufficient tomorrow. Faster and computationally lighter methods are needed for sequence retrieval. This study presents a computationally more efficient tool...

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Public examination: 22.8.2014

Copper and bacteria related to Finnish Emmental cheese

Lourdes Mato Rodriguez

Traditional Swiss Emmental utilizes copper vats, whereas Finnish Emmental is manufactured using stainless steel cheese vats, and a copper sulfate solution is added into the cheese-milk to reach copper levels in the final cheese of a maximum 15 ppm. Other manufacturers use stainless steel vats but no copper is added. Despite the economical importance of Emmental cheese for the Finnish dai...

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Public examination: 22.8.2014

Multi-stimuli responsive polymers based on calix[4]arenes and dibenzo-18-cro

Szymon Wiktorowicz

The possibility to respond to external stimuli with change in physicochemical properties of a polymeric system is appealing to a broad range of scientists as it may result in the preparation of exciting new smart materials. Whilst numerous reports exist on polymers which respond to single stimulus such as temperature, light, pH, redox, etc., the examples of multiple stimuli responsive po...

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Public examination: 22.8.2014

Delivery of biologics to the retinal pigment epithelium

Astrid Subrizi

Biologics are increasingly used in the treatment of ocular diseases such as age-related macular degeneration (AMD) that cannot be controlled with conventional small molecule drugs. AMD is a multifactorial eye disease that carries significant risk of morbidity and vision loss. In Finland and other western countries, AMD affects one in three people older than 75 years, and until the early ...

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Public examination: 22.8.2014

Yhteen- ja vähennyslaskustrategioiden rakentaminen alkuopetuksen matematiikassa : Yhden luokan oppilaiden erilaiset oppimispolut tehokkaisiin strategioihin

Jari Lakka

Tutkimuksessa selvitetään 1. ja 2. luokan oppilaiden käyttämiä laskustrategioita yhteen- ja vähennyslaskuissa. Pohjana laskustrategioiden kehittymiselle nähdään lukukäsitteen kehittyminen. Laskustrategioita tutkitaan niiden kehittymisestä puutteellisista strategioista aina tehtävän automatisoitumiseen asti. Samalla sivutaan päässälaskustrategioita (mentaalisia strategioita). Aihetta on m...

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Public examination: 22.8.2014

Bidrag till Fennoskandiens språkliga förhistoria i tid och rum

Mikko Heikkilä

Väitöskirjassani "Bidrag till Fennoskandiens språkliga förhistoria i tid och rum" ("Aikapaikkaisia lisiä Fennoskandian kielelliseen esihistoriaan") tutkin poikkitieteellistä lähestymistapaa noudattaen Pohjois-Euroopan kielellistä esihistoriaa erityisesti rautakaudella (n. 700 eKr.―1200 jKr.), mutta jonkin verran myös pronssikaudella (n. 1700―700 eKr.) ja Suomen varhaiskeskiajalla (n. 120...

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Public examination: 23.8.2014

Continuous Context Inference on Mobile Platforms

Bhattacharya, Sourav

In this thesis we develop novel methods for continuous and sustained context inference on mobile platforms. We address challenges present in real-world deployment of two popular context recognition tasks within ubiquitous computing and mobile sensing, namely localization and activity recognition. In the first part of the thesis, we provide a new localization algorithm for mobile devices ...

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Public examination: 25.8.2014

Molecular dynamics simulations of drug delivery liposomes and their interactions with bloodstream elements

Aniket Magarkar

Drug delivery is a vital issue in pharmaceutical research; once a drug candidate molecule is identified, it must be delivered to the target area of the body where it can take effect. In addition, non-specific distribution of drug molecules to areas other than the drug target must be decreased to avoid unwanted side effects. To achieve this, nanotechnological drug delivery systems can be ...

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Public examination: 25.8.2014

Vienan Karjalan asutushistoria nimistön valossa

Denis Kuzmin

Väitöskirjatutkimuksen kohteena on Vienan Karjalan asutuksen muodostuminen ennen kaikkea paikannimistön valossa. Väitöstutkimuksen pääosa koostuu kuudesta artikkelista, joiden keskeisenä teemana on nykyisen Karjalan tasavallan pohjoisosien etninen historia. Tutkimus keskittyy historiallisissa lähteissä mainittuihin etnisiin ryhmiin kuten saamelaisiin, karjalaisiin, hämäläisiin, savolaisi...

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Public examination: 27.8.2014

Pseudopeptides and Peptidomimetics Modulating the Proteolytic Activity of Kallikrein-related Peptidase 3

Kristian Meinander

The highly prostate specific serine protease kallikrein-related peptidase 3 (KLK3, also known as prostate specific antigen, PSA) is widely used as a biomarker for prostate cancer and it has also been postulated that it may play a part in tumour growth. Especially interestesting is the antiangiogenic effect exerted by proteolytically active KLK3 in cell line models. In order to stimulate ...

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Public examination: 28.8.2014

Micronuclei in Human peripheral Lymphocytes - Mechanistic Origin and Use as a Biomarker of Genotoxic Effects in Occupational Exosure

Ghita Falck

The formation of micronuclei (MN) in peripheral blood lymphocytes represents one of the earliest cytogenetic effects of exposure to genotoxic carcinogens. An increased frequency of MN and of other cytogenetic alterations, such as chromosomal aberrations and sister chromatid exchanges, in a well-controlled study of occupationally exposed people, is usually considered a strong indication o...

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Public examination: 29.8.2014

Second language lexis and the idiom principle

Svetlana Vetchinnikova

This work sets out to examine how second language (L2) users of English acquire, use and process lexical items. For this purpose three types of data were collected from five non-native students of the University of Helsinki. First, each student s drafts of Master s thesis chapters written over a period of time were compiled into a language usage corpus. Second, academic publications a st...

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Public examination: 29.8.2014

Russian Greatpowerness: Foreign policy, the Two Chechen Wars and International Organisations

Hanna Smith

This dissertation addresses the difficulties encountered in international relations between Russia and the West, specifically Europe, in spite of their cultural and geographical proximity and the expectation that Russia and Europe would share values and interests following the collapse of the Soviet Union. The problem is addressed through focussing on a particular aspect of Russia s nati...

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Public examination: 29.8.2014

A taxonomic revision of the Taeniidae Ludwig, 1886 based on molecular phylogenies

Antti Lavikainen

The most pathogenic zoonotic cestodes of humans belong to the family Taeniidae. Members of this family (taeniids) are parasites of mammals requiring predatory definitive hosts and herbivorous or omnivorous intermediate hosts. Due to the major medical, veterinary and economic importance, taeniids have been a topic of intensive taxonomic, ecological and epidemiological studies resulting in...

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Public examination: 29.8.2014

Porous Silicon-Based Multicomposites for Controlled Drug Delivery

Dongfei Liu

The co-loading of different therapeutic molecules into a single carrier offers several advantages over individual administration. The aim of this dissertation was to develop a robust platform that would enable precise control over the loading and release of different drug cargos to facilitate combination therapy.

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Public examination: 29.8.2014

Ischaemia-Reperfusion-Induced Kidney Injury : Experimental studies on the effects of caloric restriction, AMPK activator AICAR and α2-adrenoceptor agonists in the rat

Juha Lempiäinen

Ischaemia-reperfusion (I/R) injury of the kidneys is a common cause of acute kidney injury (AKI). The incidence of AKI among hospitalized patients is between 2-10%, and the mortality rates are high. Currently there is no medication for AKI. The aim of the present study was to increase our knowledge of the pathophysiological mechanisms underlying ischaemic AKI and to identify tentative dr...

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Public examination: 29.8.2014

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Molecular cloning, and preliminary phenotypic and molecular characterization of the Flower-related Ubiquitin E3 ligases

Govindan, Ashokkumar / 20.08.2014

Molecular cloning, and preliminary phenotypic and molecular characterization of the Flower-related Ubiquitin E3 ligases Govindan, Ashokkumar Ubiquitin-mediated proteolysis regulates many basic cellular processes in plant development. Especially, in Arabidopsis thaliana over 1400 genes encode components of the ubiquitin/26S proteasome pathway. Approximately, 90% of the genes encode subuni...

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Utilization of modified wood shavings as growing media for selected horticultural crops

Binte Mostafiz, Suraiya / 19.08.2014

Utilization of modified wood shavings as growing media for selected horticultural crops Binte Mostafiz, Suraiya Plant production in soilless systems is attracting increased interest day by day. The major reason for these interest is the fact that soilless medium can help to eliminate soil-borne diseases and give an understanding of plant nutritional requirements. The aim of this thesis i...

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Kalatuotteiden valinta: saatavilla olevien laatuvihjeiden merkitys ja kuluttajan kyvyt kalatuotteiden arvioinnissa

Ekström, Hanna / 18.08.2014

Kalatuotteiden valinta: saatavilla olevien laatuvihjeiden merkitys ja kuluttajan kyvyt kalatuotteiden arvioinnissa Ekström, Hanna Kala on maailmanlaajuisesti tunnistettu tärkeäksi elintarvikkeeksi ja tarjoaa elinkeinon suurelle määrälle maailman väestöä. Se on myös yksilötasolla tärkeä osa ravitsemusta. Kalan kulutuksen tutkiminen on tärkeää, sillä siten saadaan tietoa kuluttajien mielty...

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Suomenopettajien kielivalinnat : Käytännöt, motiivit, käsitykset

Jäppinen, Leo / 20.08.2014

Suomenopettajien kielivalinnat : Käytännöt, motiivit, käsitykset Jäppinen, Leo Tutkielma käsittelee suomenopettajien luokkahuoneessa puhumia kieliä. Kielten käytön lisäksi siinä tarkastellaan opettajien motiiveja kielivalinnoilleen sekä heidän käsityksiään suomenopetuksen vaikutuksesta opiskelijan oman äidinkielen taitoon ja arvostukseen sekä identiteettiin. Erityisesti keskitytään opisk...

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