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Functions of morphosyntactic alternations, and information flow in Surgut Khanty Discourse

Sachiko Sosa

Khanty is a Uralic language spoken in Western Siberia. Surgut Khanty with 2000 speakers is one of the variants of Eastern Khanty. Most speakers are bilinguals and Surgut Khanty is nowadays an endangered language. The main aim of this dissertation is to find the functions of rich morphosyntactic devices in Surgut Khanty. I limited the analysis on comparisons variation between alignments. ...

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Public examination: 31.5.2017

J.V. Snellmans Philosophie der Persönlichkeit

Lauri Kallio

The study discusses the philosophy of Finnish philosopher J.V. Snellman (1806-81). The focus is on Snellman's so-called philosophy of personality, which he presented in his work "Essay on the speculative Development of the Idea of Personality" (Tübingen, 1841). Besides this work he addressed his philosophy of personality in his other works and in his public lectures. In his philosophy of...

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Public examination: 1.6.2017

Oral health in patients with chronic kidney disease - emphasis on periodontitis

Karita Nylund

Background: Periodontitis is a common bacteria-induced chronic inflammatory disease with mild symptoms. It leads to destruction of the periodontium and finally to tooth loss in a susceptible patient. Periodontitis is associated with many systemic diseases such as diabetes, atherosclerosis, cardiovascular diseases, and chronic kidney disease (CKD) through low-grade systemic inflammation. ...

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Public examination: 1.6.2017

Early Treatment Prediction and Immunological Effects of Tyrosine Kinase Inhibitor Therapy in Chronic-Phase Chronic Myeloid Leukemia

Mohamed Mostafa Mohamed Ahmed El Missiry

Tyrosine kinase inhibitors (TKIs) blocking the BCR-ABL1 oncokinase activity have led to a revolutionary progress in the treatment and prognosis of chronic myeloid leukemia (CML). Nevertheless, a small fraction of patients still does not respond satisfactorily to TKI treatment. Therefore, early prediction of treatment response remains one of the major research focuses in order to perform ...

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Public examination: 2.6.2017

On the solar radiative effects of atmospheric ice and dust

Päivi Haapanala

Both atmospheric ice and mineral dust are considered to play important roles in our climate system through their impacts on the radiative energy budget. These impacts depend on the size, shape, composition and concentration of the ice and dust particles. However, the non-spherical shape of these particles yields uncertainties in our understanding how they interact with radiation. One of ...

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Public examination: 2.6.2017

Nicotine Dependence ? Identifying the Contribution of Specific Genes

Jenni Hällfors

Cigarette smoking is a worldwide health burden causing several diseases. Chronic obstructive pulmonary disease, heart disease and several cancers remain the main avoidable causes for premature deaths. Among smokers, tobacco use is largely motivated by nicotine dependence (ND). Smoking is influenced by the complex interplay between genetic vulnerability, environmental risk factors and ind...

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Public examination: 2.6.2017

Finnish population genetics in a forensic context

Anu Neuvonen

Finland’s unusual history and resulting genetic structure have a number of consequences for the practical applications of genetic testing in Finland today, including forensic analysis. The objective of this study was to characterize coding and noncoding genetic variation in the Finnish gene pool using forensic markers, in order to improve the efficiency of forensic testing in Finland whi...

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Public examination: 2.6.2017

Uncovering a sugar tolerance network: SIK3 and Cabut as downstream effectors of Mondo-Mlx

Meri Teesalu

Simple carbohydrates constitute a big part of our everyday diet, as significant consumption increases have occurred in recent decades. This has coincided with a dramatic rise in people suffering from metabolic disorders, such as diabetes and obesity. However, the genetic factors ensuring a healthy response to sugar intake remain poorly understood. To keep blood glucose in a healthy range...

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Public examination: 2.6.2017

Physical health of patients with schizophrenia: findings from a health examination study

Saana Eskelinen

Patients with schizophrenia have an increased risk of comorbid somatic diseases compared to the general population. Their life expectancy is reduced by ca. 15 years, mostly due to premature deaths from physical conditions. Regular evaluation of physical health is recommended in the schizophrenia treatment guidelines. However, the overall picture of somatic problems emerging in a comprehe...

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Public examination: 2.6.2017

Superovulation and embryo transfer in dairy cattle – effect of management factors with emphasis on sex-sorted semen

Marja Mikkola

Multiple ovulation and embryo transfer (MOET) has been established in cattle breeding since the 1970s. It is an efficient means to increase the number of offspring from genetically superior females. Despite nearly 50 years of development, the average number of transferable embryos recovered in a single embryo collection has remained nearly constant at approximately six embryos per donor....

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Public examination: 2.6.2017

Outcome of long-term language contact - Transfer of Egyptian phonological features onto Greek in Graeco-Roman Egypt

Sonja Dahlgren

In this work I have studied the language contact situation between Egyptian and Greek in Roman period Egypt. I have analysed the language use of a corpus written by Egyptian scribe apprentices, OGN I (Ostraca greci da Narmuthis), rich with nonstandard variation due to the imperfect Greek learning of the young scribes. I concentrated on finding Egyptian phonological influence from the mis...

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Public examination: 3.6.2017

Suomen musiikkioppilaitoshistoriaa - Toiminta ulkomaisten esikuvien pohjalta vuoteen 1969

Jukka Kuha

Tutkimus koskee maamme institutionaalisten musiikkioppilaitosten historiaa Ruotsin vallan ajalta vuoteen 1969. Sille niin sanottuna punaisena lankana on laajahko selvitys musiikkikoulutuksen ja musiikkioppilaitosten syntymisestä Euroopassa, koska ulkomailta saatiin esikuvat maamme oppilaitoksille. Tarkastelun kohteina ovat edelliseen sisältyvinä akatemioiden, musiikkiakatemioiden ja ylio...

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Public examination: 5.6.2017

Spatio-temporal perspectives on aquatic carbon dynamics and limnoecological change in climate-sensitive lakes

Marttiina Rantala

Northern lakes are displaying widespread ecological reorganizations in response to global change. These sensitive freshwater ecosystems are an integral component of subarctic and arctic landscapes and play a critical role in regional and global biogeochemical cycles. To understand lake ecosystem responses to direct and indirect climate forcing, and to estimate future trajectories of envi...

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Public examination: 7.6.2017

Exploring Hand-Based Haptic Interfaces for Mobile Interaction Design

Yi-Ta Hsieh

Visual attention is crucial in mobile environments, not only for staying aware of dynamic situations, but also for safety reasons. However, current mobile interaction design forces the user to focus on the visual interface of the handheld device, thus limiting the user's ability to process visual information from their environment. In response to these issues, a common solution is to enc...

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Public examination: 8.6.2017

Geographies of wellbeing and development : Empirical analyses on the relationship between objective and subjective measures of wellbeing in Europe

Mikko Weckroth

This thesis investigates the cross-sectional association between different quantifiable societal dimensions that indicate spatially varying levels of wellbeing and development. The analysis is grounded in human geography but applies an explicitly interdisciplinary focus, combining theories and measures from economic geography, cultural studies, spatial economics, sociology and social psy...

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Public examination: 9.6.2017

Bioactive and protective polyphenolics from roots and stumps of conifer trees (Norway spruce and Scots pine)

Harri Latva-Mäenpää

The current era of bioeconomy strives to develop new, innovative products from natural raw materials in a sustainable way. In this PhD thesis, we have searched potential bioactive compounds from different parts of the neglected roots and stumps of conifer trees for high value products. Our aim was to establish deeper knowledge concerning chemical compositions of specified and defined bio...

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Public examination: 9.6.2017

Ruptured Abdominal Aortic and Iliac Artery Aneurysms

Matti Laine

Aneurysms of the abdominal aorta (AAA) or the iliac arteries (IAA) are potentially lethal conditions that can be treated with surgical interventions. The recent shift towards endovascular treatment has resulted in lower immediate mortality from elective AAA surgery. Because of the high mortality from ruptured AAA (RAAA), screening programmes have been established in some countries with p...

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Public examination: 9.6.2017

Algorithms and Data Structures for Sequence Analysis in the Pan-Genomic Era

Daniel Valenzuela

This thesis is motivated by two important processes in bioinformatics, namely variation calling and haplotyping. The contributions range from basic algorithms for sequence analysis, to the implementation of pipelines to deal with real data. Variation calling characterizes an individual's genome by identifying how it differs from a reference genome. It uses reads -- small DNA fragments...

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Public examination: 9.6.2017

The Impact of Membrane Phospholipid Composition and Extracellular Vesicles on the Immunoregulative Properties of Human Mesenchymal Stromal Cells

Lotta Kilpinen

Human mesenchymal stromal cells (hMSCs) are currently used in many advanced cellular therapies. The clinical use of hMSCs requires extensive cell expansion, but the consequences of expansion, especially at the molecular level, are not fully understood. The therapeutic effect of hMSCs is mediated paracrine interactions with immune cells modulating both innate and adaptive immune response....

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Public examination: 9.6.2017

Poetiikka ja pietismi 1700- ja 1800-luvun suomalaisessa virsirunoudessa

Eeva-Liisa Bastman

Tutkimus käsittelee pietististen herätysliikkeiden piirissä 1700- ja 1800-luvun vaihteessa syntynyttä suomenkielistä virsirunoutta. Tutkimuksessa tarkastellaan virttä lyriikan lajina ja virsirunouden poetiikkaa, eli virrelle tyypillisiä muodollisia ja sisällöllisiä piirteitä ja lajille ominaisia merkityksenmuodostamisen tapoja. Tutkimuksen keskiössä on kaksi virsikokoelmaa: 1780-luvun Or...

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Public examination: 9.6.2017

Save the nation! A social psychological study of political blogs as a medium for nationalist communication and persuasion

Katarina Pettersson

This doctoral dissertation explores how populist radical right politicians in Finland and Sweden use political blogs for the purpose of nationalist political communication and persuasion. The study builds upon research that has highlighted the growing importance of social media in the transmission of radical right, nationalist and anti-immigration political discourse, and to the central ...

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Public examination: 9.6.2017

Etiopathogenesis and Treatment of Localized Provoked Vulvodynia

Päivi Tommola

Localized provoked vulvodynia (LPV), a subset of vulvodynia, is associated with pain induced by touch to the vulvar vestibular mucosa in the absence of any other recognizable disease. This results in severe dyspareunia. LPV mostly affects young fertile-aged women, with an incidence of 8-15%. LPV severely impairs a patient s quality of life, and can even result in infertility since women ...

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Public examination: 9.6.2017

Esophageal Adenocarcinoma: Pathogenesis, Prevention, and Prognosis

Tuuli Kauttu

Esophageal adenocarcinoma (EAC) is a cancer with a poor prognosis that has increased in Western countries in the recent decades. Among its predisposing factors are gastroesophageal reflux disease, Barrett´s esophagus (BE), obesity, increasing age, and male gender. To decrease EAC incidence and to improve its prognosis, preventive methods and enhanced knowledge of its pathogenesis are ess...

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Public examination: 9.6.2017

Atomic Layer Deposition and Lithium-ion Batteries: Studies on new materials and reactions for battery development

Miia Mäntymäki

The increasing interest in both portable electronic devices and electric vehicles has given rise to a new wave of research into lithium-ion batteries. Lithium-ion batteries are the technology of choice for these applications, as they offer both high power and high energy densities. However, much research on this subject is still needed to answer the technology demands of future applicati...

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Public examination: 9.6.2017

Tulkintojen ristitulessa - Kristian Smedsin Tuntematon sotilas teatteri- ja mediaesityksenä

Julia Pajunen

Väitöskirjani on tapaustutkimus Kristian Smedsin Suomen Kansallisteatteriin ohjaamasta ja sovittamasta Tuntemattomasta sotilaasta (2007–2009). Tutkimustehtäväni on selvittää miten Smedsin ohjaus tuotti performatiivisen jännitteen säilyttämisen ja uudelleen luomisen välille kansallisteoksena pidetyn romaanin uudelleentulkinnalla. Tutkin Smedsin Tuntemattoman sotilaan teatteritapaukseksi m...

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Public examination: 9.6.2017

Protecting Against Child-Killing Demons: Uterus Amulets in the Late Antique and Byzantine Magical World

Heta Björklund

This doctoral dissertation examines medicinal-magical amulets pertaining to the uterus and the protection of women and children, the accompanying tradition of magical texts, and the mythology and folktales of demons believed to kill children and parturient women. The amulets and the folktales of the demons they were believed to protect against are intertwined. The amulets cannot be studi...

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Public examination: 9.6.2017

Leuconostoc bacteriocins and their application in genome editing

Xing Wan

Leuconostocs are lactic acid bacteria used as starters in food fermentations. They can also be spoilage bacteria, especially in vacuum packed meat products. Many Leuconostocs produce antimicrobial peptides, also known as bacteriocins. Leuconostoc bacteriocins are usually small, less than 10 kDa non-modified peptides, which are secreted by dedicated transporters. These bacteriocins kill m...

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Public examination: 9.6.2017

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AGGREGAATTORIT ÄÄNITTEIDEN DIGITAALISESSA JAKELUSSA Tekijänoikeuslainsäädännön ja verotuksen näkökulmasta

Laine, Annina / 27.04.2017

AGGREGAATTORIT ÄÄNITTEIDEN DIGITAALISESSA JAKELUSSA Tekijänoikeuslainsäädännön ja verotuksen näkökulmasta Laine, Annina Tiivistelmä/Referat – Abstract Internet ja digitaalitekniikan kehitys on mullistanut musiikkialaa merkittävästi ja huomattava osa äänitteistä siirtyy nykyään kuuntelijalle digitaalisessa muodossa. Kuluttajille äänitemarkkinoiden digitalisoituminen merkitsee, että mus...

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Kartellivahingon määrän todistaminen vahingonkorvausoikeudenkäynnissä

Korhonen, Sofie / 27.04.2017

Kartellivahingon määrän todistaminen vahingonkorvausoikeudenkäynnissä Korhonen, Sofie Tiedekunta/Osasto Fakultet/Sektion – Faculty Oikeustieteellinen tiedekunta Laitos/Institution– Department Tekijä/Författare – Author Sofie Korhonen Työn nimi / Arbetets titel – Title Kartellivahingon määrän todistaminen vahingonkorvausoikeudenkäynnissä Oppiaine /Läroämne – Subject Oikeustalo...

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The Patent Economics of Synthetic Biology

Bützow, Alexander / 27.04.2017

The Patent Economics of Synthetic Biology Bützow, Alexander Kyseinen työ tutkii uutta bioteknologian muotoa, synteettistä biologiaa, ja sen suhdetta eurooppalaiseen immateriaalioikeuteen, erityisesti patenttioikeuteen. Tutkielman keskeiset kysymykset koskevat sen selvittämisestä, onko 1) synteettisen biologian keksinnöt systeemisesti soveltumattomia nykyiseen patenttioikeuteen, ja 2...

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Vastuun rajoittaminen asianajotoimeksiantosopimukseen perustuvan vastuunhallinnan keinona

Sotamaa, Rasmus / 27.04.2017

Vastuun rajoittaminen asianajotoimeksiantosopimukseen perustuvan vastuunhallinnan keinona Sotamaa, Rasmus Asianajajan mahdollisuuksiin rajata vastuutaan on perinteisesti suhtauduttu varovaisen torjuvasti niin Suomessa kuin muissakin Pohjoismaissa. Torjuvan suhtautumisen perusteet on usein liitetty asianajotoiminnan erityiseen luonteeseen. Vastuunrajoitukset on nähty erityisesti asianaja...

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