Bläddra eller sök avhandlingar
Vauvan syntymä perheeseen on yksi ihmiselämän suurimpia asioita. Vastaavasti odotuksen päättyminen vauvan kuolemaan kohdussa, synnytyksessä tai pian syntymän jälkeen on ihmistä perustavanlaatuisesti koskettava ja järkyttävä asia. Länsimaisessa hyvinvointivaltiossa asian järkyttävyyttä lisää se, että on totuttu uskomaan lääketieteen mahdollisuuksiin pitää odotettu vauva hengissä. Kun kast...
Disputationen: 21.9.2018
Many mathematical models of population dynamics are formulated as Volterra integral equations coupled with integro-differential equations. They can be interpreted as delay equations, where the value of a function, or its derivative, is prescribed in terms of the past values. Because delay equations generate infinite-dimensional dynamical systems, it often proves impossible to get analyti...
Disputationen: 21.9.2018
Introduction: Modern HIV therapy has dramatically changed the life expectancy of HIV-positive people. For the past 20 years, annual cervical screening with Papanicolaou (PAP) smears has been recommended for all women living with HIV (WLWH) due to the excess risk of squamous intraepithelial lesions (SIL) and invasive cervical cancer. Increasing life expectancy and good physical health has...
Disputationen: 21.9.2018
Northern circumpolar permafrost peatlands store ~300 Pg of organic carbon (C), and play a critical role in regulating global biogeochemical cycles. Amplified warming in high-latitude regions is threatening this large C stock, because permafrost thawing will expose previously frozen C to decomposition. Permafrost thaw-induced hydrological changes together with warming will influence plant...
Disputationen: 21.9.2018
This thesis consists of two parts where Indoor Environmental Quality is studied in the first part by analyzing polycyclic aromatic hydrocarbons (PAHs) and biological contamination levels in floor dust inside an educational building and dwellings within the capital city of Jordan (Amman). Exposure, dose and health risk assessments of PAHs were also performed. The second part investigates ...
Disputationen: 21.9.2018
Blood and lymphatic vessels form extensive networks, which deliver oxygen and nutrients to the tissues and remove extravasated fluid. Malfunction of this vasculature results in various diseases such as tumors and ischemic and inflammatory diseases and lymphedema. The molecular mechanism by which vascular endothelial receptors (VEGFRs) control vessel growth and function in physiological a...
Disputationen: 21.9.2018
The global discourse on people-centered development appeals for a normative dimension in donor policies. As a major donor organization, the European Union (EU) presents itself as a normative actor on the global stage. However, it is often criticized for lacking normative practice. This dissertation addresses this criticism and assesses the EU’s normative policy coherence for development ...
Disputationen: 22.9.2018
Carbon dioxide is often considered a comparatively unreactive molecule due to its nonpolar nature and the presence of strong double bonds. However, its electron-deficient carbon atom is susceptible to nucleophilic attack, a property that has been exploited in organic synthesis for well over a century. If the nucleophilic attack is performed by an amine, a carbamate species is formed. Th...
Disputationen: 28.9.2018
Human-induced disturbances may change vegetation and carbon (C) and nitrogen (N) processes in the forest floor and the soil beneath it. The aim of this dissertation was to study the effects of physical and chemical disturbance on boreal forest soil and vegetation. Two contrasting soil-affecting treatments – stump harvesting and sprinkling infiltration – were studied as case studies. Spri...
Disputationen: 28.9.2018
Patient reporting of adverse drug reactions (ADRs) has become an important element of pharmacovigilance. The aim of this thesis was to research the value of patient reporting of ADRs to pharmacovigilance systems. The study consists of 4 original studies, of which study I and II are interrelated. Study I identified which are the clinical and subjective aspects of adverse drug reactions (A...
Disputationen: 28.9.2018
The acute phase response (APR) is a component of the innate immune system, a general and non-specific response that limits the spread of infection and removes factors potentially harmful to the body. Infection, neoplasm or tissue trauma initiates an acute phase response, resulting in visible systemic signs of illness, fever, reduction of appetite and depression. APR also induces a variet...
Disputationen: 28.9.2018
The total number of induced abortions has declined, but the 32–45% proportion of repeat abortions has remained stable. Medical abortion has replaced the surgical method and up to 97% of abortions are medically induced today in Finland. Long-acting reversible contraception (LARC), i.e., intrauterine devices and contraceptive implants, is very effective. Initiation of LARC methods at the t...
Disputationen: 28.9.2018
Emotions have various effects in work life and in organizational social interaction. Daily work events evoke emotional reactions, which are communicated to colleagues and clients. The communicated emotions may evoke corresponding affective response in the perceiver and, thus, the emotions become social. Existing emotional state may have an effect on the performance of work tasks, such as...
Disputationen: 28.9.2018
Chronic dental diseases are highly prevalent worldwide. The possible associations between oral diseases and general health have been studied and periodontitis has been associated with cardiovascular diseases, diabetes, pre-term and low-birth weight infants, Alzheimer’s disease, and also with cancer. Apical periodontitis associates with cardiovascular diseases and diabetes. Nevertheless, ...
Disputationen: 28.9.2018
Beef production in Finland is mostly based on dairy breeds. To compensate for the lack of domestic beef, slaughterhouse pricing favours lean and heavy carcasses. Higher carcass weights increase the probability of increasing fatness. It is necessary to control fatness because consumers generally favour low-fat products. In addition, excessive fat accumulation decreases the efficiency of f...
Disputationen: 28.9.2018
In community ecology, we are interested in the patterns of occurrence and abundance of multiple species coexisting and interacting in an area or habitat. There is a large array of modelling methods that can be used as species distribution models, each of which based on different assumptions on how the surrounding conditions affect the distribution of species and communities. Teasing apar...
Disputationen: 28.9.2018
Understanding use by and movement of people in urban green spaces is important to planning and management in order to balance between multiple user needs and the preservation of natural resources as ecologically and socially viable. Yet, in the current literature, little attention is paid to the intraspatial (i.e. within the area) behaviour of visitors and how this relates to the socio-e...
Disputationen: 28.9.2018
The purpose of this work was to develop a formulation method to produce high quality inhalable dry powder, to formulate an anti-fibrotic small molecule tilorone to a respirable form, and to assess its anti-fibrotic potential in pulmonary administration. The aerosol flow reactor method was used to produce carrier-free formulations of water soluble and insoluble drugs as well as combinati...
Disputationen: 28.9.2018
Breast cancer is the most diagnosed malignancy and the leading cause of cancer mortality in women worldwide. In Finland, approximately 5,000 cases are diagnosed annually, constituting about 30% of all new female cancers. Although commonly referred to as a single disease, breast cancer is a clinically and morphologically heterogeneous disorder. Different histologic and molecular subtypes ...
Disputationen: 28.9.2018
Environmental security is broadly defined as a concept concerned with the relationship of threats between environmental change and human society. While its focus often is on the consequences of environmental threats like pollution and climate change, it also entails the potential of environment to serve as a basis for cooperation. This Doctoral dissertation is a historical analysis of th...
Disputationen: 29.9.2018
Chronic pain impairs health and both physical and cognitive function, and is associated with considerable psychosocial problems. The management of chronic pain is challenging, and multidisciplinary pain management (MPM) is considered the most efficacious method of treating chronic pain. However, treatment outcomes vary greatly, and it is not possible to predict which patients will benefi...
Disputationen: 29.9.2018
Olavi Kares (1903–1988) oli yksi toisen maailmansodan jälkeisen ajan keskeisimmistä herännäisvaikuttajista. Hän oli myös merkittävä kirkollinen vaikuttaja. Tutkimukseni lähtökohta on, että Kareksessa tapahtui aatteellinen ja uskonnollis-teologinen muutos. Selvitän, miten hänen ajattelunsa muuttui, mistä muutokset johtuvat ja mitä vaikutuksia tällä muutoksella oli. Toisen maailmansodan jä...
Disputationen: 29.9.2018
AGGREGAATTORIT ÄÄNITTEIDEN DIGITAALISESSA JAKELUSSA Tekijänoikeuslainsäädännön ja verotuksen näkökulmasta Laine, Annina Tiivistelmä/Referat – Abstract Internet ja digitaalitekniikan kehitys on mullistanut musiikkialaa merkittävästi ja huomattava osa äänitteistä siirtyy nykyään kuuntelijalle digitaalisessa muodossa. Kuluttajille äänitemarkkinoiden digitalisoituminen merkitsee, että mus...
Kartellivahingon määrän todistaminen vahingonkorvausoikeudenkäynnissä Korhonen, Sofie Tiedekunta/Osasto Fakultet/Sektion – Faculty Oikeustieteellinen tiedekunta Laitos/Institution– Department Tekijä/Författare – Author Sofie Korhonen Työn nimi / Arbetets titel – Title Kartellivahingon määrän todistaminen vahingonkorvausoikeudenkäynnissä Oppiaine /Läroämne – Subject Oikeustalo...
The Patent Economics of Synthetic Biology Bützow, Alexander Kyseinen työ tutkii uutta bioteknologian muotoa, synteettistä biologiaa, ja sen suhdetta eurooppalaiseen immateriaalioikeuteen, erityisesti patenttioikeuteen. Tutkielman keskeiset kysymykset koskevat sen selvittämisestä, onko 1) synteettisen biologian keksinnöt systeemisesti soveltumattomia nykyiseen patenttioikeuteen, ja 2...
Vastuun rajoittaminen asianajotoimeksiantosopimukseen perustuvan vastuunhallinnan keinona Sotamaa, Rasmus Asianajajan mahdollisuuksiin rajata vastuutaan on perinteisesti suhtauduttu varovaisen torjuvasti niin Suomessa kuin muissakin Pohjoismaissa. Torjuvan suhtautumisen perusteet on usein liitetty asianajotoiminnan erityiseen luonteeseen. Vastuunrajoitukset on nähty erityisesti asianaja...