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Kun vauvaonni vaihtuu kuoleman suruun - Narratiivinen tutkimus kohtukuolemasta, lapsen kuoleman aiheuttamasta surusta ja selviytymisprosessista sekä kirkon tuesta

Juha Itkonen

Vauvan syntymä perheeseen on yksi ihmiselämän suurimpia asioita. Vastaavasti odotuksen päättyminen vauvan kuolemaan kohdussa, synnytyksessä tai pian syntymän jälkeen on ihmistä perustavanlaatuisesti koskettava ja järkyttävä asia. Länsimaisessa hyvinvointivaltiossa asian järkyttävyyttä lisää se, että on totuttu uskomaan lääketieteen mahdollisuuksiin pitää odotettu vauva hengissä. Kun kast...

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Disputationen: 21.9.2018

Capture the past to portray the future - Numerical bifurcation analysis of delay equations, with a focus on population dynamics

Francesca Scarabel

Many mathematical models of population dynamics are formulated as Volterra integral equations coupled with integro-differential equations. They can be interpreted as delay equations, where the value of a function, or its derivative, is prescribed in terms of the past values. Because delay equations generate infinite-dimensional dynamical systems, it often proves impossible to get analyti...

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Disputationen: 21.9.2018

Sexual and reproductive health of women living with HIV in Finland

Inka Aho

Introduction: Modern HIV therapy has dramatically changed the life expectancy of HIV-positive people. For the past 20 years, annual cervical screening with Papanicolaou (PAP) smears has been recommended for all women living with HIV (WLWH) due to the excess risk of squamous intraepithelial lesions (SIL) and invasive cervical cancer. Increasing life expectancy and good physical health has...

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Disputationen: 21.9.2018

Responses of Arctic permafrost peatlands to climate changes over the past millennia

Hui Zhang

Northern circumpolar permafrost peatlands store ~300 Pg of organic carbon (C), and play a critical role in regulating global biogeochemical cycles. Amplified warming in high-latitude regions is threatening this large C stock, because permafrost thawing will expose previously frozen C to decomposition. Permafrost thaw-induced hydrological changes together with warming will influence plant...

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Disputationen: 21.9.2018

Exposure to coarse particles and floor dust biological and chemical contamination inside Jordanian indoor environments

Androniki Maragkidou

This thesis consists of two parts where Indoor Environmental Quality is studied in the first part by analyzing polycyclic aromatic hydrocarbons (PAHs) and biological contamination levels in floor dust inside an educational building and dwellings within the capital city of Jordan (Amman). Exposure, dose and health risk assessments of PAHs were also performed. The second part investigates ...

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Disputationen: 21.9.2018

Analysis of vascular endothelial growth factor - receptor functions in gene-targeted mice

Krista Heinolainen

Blood and lymphatic vessels form extensive networks, which deliver oxygen and nutrients to the tissues and remove extravasated fluid. Malfunction of this vasculature results in various diseases such as tumors and ischemic and inflammatory diseases and lymphedema. The molecular mechanism by which vascular endothelial receptors (VEGFRs) control vessel growth and function in physiological a...

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Disputationen: 21.9.2018

Normative Policy Coherence for Development in EU External Policies : A Case Study of the European Union's Development and Trade Policies towards Vietnam

Sandra Häbel

The global discourse on people-centered development appeals for a normative dimension in donor policies. As a major donor organization, the European Union (EU) presents itself as a normative actor on the global stage. However, it is often criticized for lacking normative practice. This dissertation addresses this criticism and assesses the EU’s normative policy coherence for development ...

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Disputationen: 22.9.2018

Carbon dioxide-based syntheses of oxazolidinones and other cyclic carbamates

Teemu Niemi

Carbon dioxide is often considered a comparatively unreactive molecule due to its nonpolar nature and the presence of strong double bonds. However, its electron-deficient carbon atom is susceptible to nucleophilic attack, a property that has been exploited in organic synthesis for well over a century. If the nucleophilic attack is performed by an amine, a carbamate species is formed. Th...

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Disputationen: 28.9.2018

Soil changes and long-term ecosystem recovery from physical and chemical load – stump harvesting and sprinkling infiltration as case studies

Lilli Kaarakka

Human-induced disturbances may change vegetation and carbon (C) and nitrogen (N) processes in the forest floor and the soil beneath it. The aim of this dissertation was to study the effects of physical and chemical disturbance on boreal forest soil and vegetation. Two contrasting soil-affecting treatments – stump harvesting and sprinkling infiltration – were studied as case studies. Spri...

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Disputationen: 28.9.2018

The Value of Patient Reporting of Adverse Drug Reactions to the Pharmacovigilance Systems

Pedro Inacio

Patient reporting of adverse drug reactions (ADRs) has become an important element of pharmacovigilance. The aim of this thesis was to research the value of patient reporting of ADRs to pharmacovigilance systems. The study consists of 4 original studies, of which study I and II are interrelated. Study I identified which are the clinical and subjective aspects of adverse drug reactions (A...

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Disputationen: 28.9.2018

Acute phase proteins in healthy and sick dairy and beef calves and their association with growth

Leena Seppä-Lassila

The acute phase response (APR) is a component of the innate immune system, a general and non-specific response that limits the spread of infection and removes factors potentially harmful to the body. Infection, neoplasm or tissue trauma initiates an acute phase response, resulting in visible systemic signs of illness, fever, reduction of appetite and depression. APR also induces a variet...

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Disputationen: 28.9.2018

Long-acting reversible contraception (LARC) after medically induced abortion

Riina Korjamo

The total number of induced abortions has declined, but the 32–45% proportion of repeat abortions has remained stable. Medical abortion has replaced the surgical method and up to 97% of abortions are medically induced today in Finland. Long-acting reversible contraception (LARC), i.e., intrauterine devices and contraceptive implants, is very effective. Initiation of LARC methods at the t...

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Disputationen: 28.9.2018

Emotions and psychophysiological responses in organizational social interaction

Mikko Salminen

Emotions have various effects in work life and in organizational social interaction. Daily work events evoke emotional reactions, which are communicated to colleagues and clients. The communicated emotions may evoke corresponding affective response in the perceiver and, thus, the emotions become social. Existing emotional state may have an effect on the performance of work tasks, such as...

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Disputationen: 28.9.2018

CHRONIC DENTAL DISEASES AND SYSTEMIC HEALTH: CARDIOVASCULAR DISEASES AND CANCER

Eunice Virtanen

Chronic dental diseases are highly prevalent worldwide. The possible associations between oral diseases and general health have been studied and periodontitis has been associated with cardiovascular diseases, diabetes, pre-term and low-birth weight infants, Alzheimer’s disease, and also with cancer. Apical periodontitis associates with cardiovascular diseases and diabetes. Nevertheless, ...

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Disputationen: 28.9.2018

Restricted energy intake strategies for growing and finishing dairy bulls offered grass silage-based diets

Katariina Manni

Beef production in Finland is mostly based on dairy breeds. To compensate for the lack of domestic beef, slaughterhouse pricing favours lean and heavy carcasses. Higher carcass weights increase the probability of increasing fatness. It is necessary to control fatness because consumers generally favour low-fat products. In addition, excessive fat accumulation decreases the efficiency of f...

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Disputationen: 28.9.2018

Analysing Ecological Communities with Joint Species Distribution Models

Anna Norberg

In community ecology, we are interested in the patterns of occurrence and abundance of multiple species coexisting and interacting in an area or habitat. There is a large array of modelling methods that can be used as species distribution models, each of which based on different assumptions on how the surrounding conditions affect the distribution of species and communities. Teasing apar...

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Disputationen: 28.9.2018

An integrative perspective on visitor spatial behaviour in urban green spaces : Linking movement, motivations, values and biodiversity for participatory planning and management

Silviya Korpilo

Understanding use by and movement of people in urban green spaces is important to planning and management in order to balance between multiple user needs and the preservation of natural resources as ecologically and socially viable. Yet, in the current literature, little attention is paid to the intraspatial (i.e. within the area) behaviour of visitors and how this relates to the socio-e...

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Disputationen: 28.9.2018

Inhalable antifibrotic compounds - Development of a formulation method and formulation of antifibrotic small molecule tilorone as inhalable dry powder

Ville Vartiainen

The purpose of this work was to develop a formulation method to produce high quality inhalable dry powder, to formulate an anti-fibrotic small molecule tilorone to a respirable form, and to assess its anti-fibrotic potential in pulmonary administration. The aerosol flow reactor method was used to produce carrier-free formulations of water soluble and insoluble drugs as well as combinati...

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Disputationen: 28.9.2018

FANCM Mutations in Breast Cancer Risk and Survival

Johanna Kiiski

Breast cancer is the most diagnosed malignancy and the leading cause of cancer mortality in women worldwide. In Finland, approximately 5,000 cases are diagnosed annually, constituting about 30% of all new female cancers. Although commonly referred to as a single disease, breast cancer is a clinically and morphologically heterogeneous disorder. Different histologic and molecular subtypes ...

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Disputationen: 28.9.2018

International Organisations and the Securitisation of the Environment in Post-Conflict Western Balkans

Emma Hakala

Environmental security is broadly defined as a concept concerned with the relationship of threats between environmental change and human society. While its focus often is on the consequences of environmental threats like pollution and climate change, it also entails the potential of environment to serve as a basis for cooperation. This Doctoral dissertation is a historical analysis of th...

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Disputationen: 29.9.2018

Health-related quality of life in patients with chronic pain

Pekka Vartiainen

Chronic pain impairs health and both physical and cognitive function, and is associated with considerable psychosocial problems. The management of chronic pain is challenging, and multidisciplinary pain management (MPM) is considered the most efficacious method of treating chronic pain. However, treatment outcomes vary greatly, and it is not possible to predict which patients will benefi...

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Disputationen: 29.9.2018

Pietististä humanistiksi? : Olavi Kares herännäisyyden, kirkon ja yhteiskunnan muutoksen keskellä 1945 - 1974

Kimmo Ylikangas

Olavi Kares (1903–1988) oli yksi toisen maailmansodan jälkeisen ajan keskeisimmistä herännäisvaikuttajista. Hän oli myös merkittävä kirkollinen vaikuttaja. Tutkimukseni lähtökohta on, että Kareksessa tapahtui aatteellinen ja uskonnollis-teologinen muutos. Selvitän, miten hänen ajattelunsa muuttui, mistä muutokset johtuvat ja mitä vaikutuksia tällä muutoksella oli. Toisen maailmansodan jä...

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Disputationen: 29.9.2018

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AGGREGAATTORIT ÄÄNITTEIDEN DIGITAALISESSA JAKELUSSA Tekijänoikeuslainsäädännön ja verotuksen näkökulmasta

Laine, Annina / 27.04.2017

AGGREGAATTORIT ÄÄNITTEIDEN DIGITAALISESSA JAKELUSSA Tekijänoikeuslainsäädännön ja verotuksen näkökulmasta Laine, Annina Tiivistelmä/Referat – Abstract Internet ja digitaalitekniikan kehitys on mullistanut musiikkialaa merkittävästi ja huomattava osa äänitteistä siirtyy nykyään kuuntelijalle digitaalisessa muodossa. Kuluttajille äänitemarkkinoiden digitalisoituminen merkitsee, että mus...

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Kartellivahingon määrän todistaminen vahingonkorvausoikeudenkäynnissä

Korhonen, Sofie / 27.04.2017

Kartellivahingon määrän todistaminen vahingonkorvausoikeudenkäynnissä Korhonen, Sofie Tiedekunta/Osasto Fakultet/Sektion – Faculty Oikeustieteellinen tiedekunta Laitos/Institution– Department Tekijä/Författare – Author Sofie Korhonen Työn nimi / Arbetets titel – Title Kartellivahingon määrän todistaminen vahingonkorvausoikeudenkäynnissä Oppiaine /Läroämne – Subject Oikeustalo...

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The Patent Economics of Synthetic Biology

Bützow, Alexander / 27.04.2017

The Patent Economics of Synthetic Biology Bützow, Alexander Kyseinen työ tutkii uutta bioteknologian muotoa, synteettistä biologiaa, ja sen suhdetta eurooppalaiseen immateriaalioikeuteen, erityisesti patenttioikeuteen. Tutkielman keskeiset kysymykset koskevat sen selvittämisestä, onko 1) synteettisen biologian keksinnöt systeemisesti soveltumattomia nykyiseen patenttioikeuteen, ja 2...

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Vastuun rajoittaminen asianajotoimeksiantosopimukseen perustuvan vastuunhallinnan keinona

Sotamaa, Rasmus / 27.04.2017

Vastuun rajoittaminen asianajotoimeksiantosopimukseen perustuvan vastuunhallinnan keinona Sotamaa, Rasmus Asianajajan mahdollisuuksiin rajata vastuutaan on perinteisesti suhtauduttu varovaisen torjuvasti niin Suomessa kuin muissakin Pohjoismaissa. Torjuvan suhtautumisen perusteet on usein liitetty asianajotoiminnan erityiseen luonteeseen. Vastuunrajoitukset on nähty erityisesti asianaja...

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