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The Evolutionary Feminism of Zhang Kangkang and the Developing Dialogue between Darwinism and Gender Studies

Qingbo Xu

This dissertation studies the work of Zhang Kangkang (a contemporary Chinese woman writer, 1950- ) in the light of evolutionary feminism (also called Darwinian feminism, which studies gender issues from an evolutionary perspective, brings feminist concerns into the fields of evolutionary biology, psychology and sociobiology, and illuminates and rectifies androcentric biases in these fiel...

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Disputationen: 5.11.2014

FROM SILENCE TO SOUNDS - Outcomes of cochlear implantation in Finnish adults and children

Eila Lonka

Individuals with profound deafness have damages in the inner and outer hair cells in the cochlea. For this reason they make only little use of frequency information and thus have minimal capacities to perceive speech sound cues. Accordingly, speech perception without augmentative means is impossible for them. Profoundly deaf children have been deprived of sound from very early stages of ...

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Disputationen: 7.11.2014

Genetics of Circulating Blood Lipids

Ida Surakka

Circulating blood lipids are well-established risk factors for cardiovascular diseases. Levels of high-density lipoprotein, low-density lipoprotein, total cholesterol, and triglycerides are affected by environmental and genetic factors. As the genetic factors explain around half of the population lipid variation based on twin studies, knowledge of the genetic determinants is crucial in p...

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Disputationen: 7.11.2014

The Toughest Season in the White House - The Rhetorical Presidency and the State of the Union Address, 1953-1992

Iwona Świątczak-Wasilewska

The present study explores the intersection of the institutional and the Rhetorical Presidency. By recognizing that the American presidency is an institution---an embodiment of the government---a researcher looks closely not only at the President as an individual, but also at the aggregate of people who co-create the institution. The Rhetorical Presidency marks the major transformation i...

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Disputationen: 7.11.2014

Internationalization of the forest industry: A corporate-level analysis

Yijing Zhang

With far-reaching impacts of economic globalization, the internationalization process of the forest industry has been accelerated. Particularly since the 1990s, internationalization has progressed intensively through industry consolidation and production relocation. Within the wood and wood products sector, for example, world inward foreign direct investment (FDI) stocks increased from 2...

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Disputationen: 7.11.2014

Genomics of bacterial and archaeal virus isolates from extreme aquatic environments

Ana Sencilo

Viruses are ubiquitous, abundant and diverse members of the biosphere. Numerous sequencing projects focusing on isolated viruses and uncultured viral communities (metaviromes) have demonstrated that viruses harbor unprecedented genotypic richness. The genomics of some viruses, for example, tailed bacteriophages infecting several widely known hosts from moderate environments, has been stu...

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Disputationen: 7.11.2014

Subgroups of Merkel cell carcinoma patients defined by young age, immunodeficiency and polyomavirus infection

Helka Sahi

Background and purpose: Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer, with a high tendency to both relapse and metastasize. 70-80% of MCCs carry the recently detected Merkel cell polyomavirus (MCV). MCV integrates clonally into the tumour genome and harbors specific mutations, which suggest a causal role in the tumorigenesis. Predispositional factors for MCC include a...

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Disputationen: 7.11.2014

Canine Models of Human Vision Disorders: Identification of New Genes and Loci for Glaucoma and Retinal Degeneration

Saija Ahonen

The availability of the genome sequence and genomic tools combined with the unique phenotypic diversity and breed structure has increased interest in dog as a large, physiologically relevant animal model for human genetic research. Dogs suffer from hundreds of hereditary conditions of which many resemble closely disorders in humans. Investigation of the genetic background of these condit...

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Disputationen: 7.11.2014

Analysing spatial accessibility patterns with travel time and distance measures: novel approaches for rural and urban contexts

Maria Salonen

Accessibility plays a key role in shaping the patterns of human activity on all spatial scales. Accessibility questions are particularly topical now that cities around the word strive for more sustainable urban mobility and information on human influence on natural systems is needed in order to better understand processes of global environmental change. Following these lines of developme...

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Disputationen: 7.11.2014

Combining multiple NMR spectroscopic approaches in study of cellulosic materials

Tommi Virtanen

The aim of this thesis was to combine several advanced nuclear magnetic resonance (NMR) spectroscopic techniques for studying the cellulose in materials still possessing, at least partly, the original complexity of wood fiber. The NMR spectroscopic approaches can be roughly divided into two classes: First, solid state NMR methods were used to characterize cellulose and its response to va...

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Disputationen: 7.11.2014

Boreal forest albedo and its spatial and temporal variation

Nea Kuusinen

Surface albedo refers to the fraction of solar irradiance that is reflected by a surface. Accurate characterisation of the albedo of various land cover types is required for evaluating the energy exchange between the Earth s surface and the atmosphere. The optical and structural properties of a surface determine its albedo. Boreal forest albedo can vary due to factors such as tree specie...

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Disputationen: 7.11.2014

Computational Studies on Direct Reconstruction Methods in Tomographic Imaging

Janne Tamminen

This thesis concerns a group of highly difficult mathematical problems whose research has risen quickly in recent years because of their applicable nature. We call these inverse problems since they have their easier counterparts, the direct problems. An inverse problem is not behaving well; it might not have a unique solution and its solution can change dramatically if the initial condit...

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Disputationen: 7.11.2014

Pathogenetic mechanisms and genotype–phenotype correlations in nemaline myopathies and related disorders caused by mutations in tropomyosin genes and nebulin

Minttu Marttila

We collected all mutations in TPM2 and TPM3 genes hitherto found to cause congenital myopathies, to perform genotype-phenotype correlations, and to increase our understanding of the pathogenetic mechanisms of congenital myopathies caused by mutations in the tropomyosin and nebulin genes. Nemaline myopathy (NM), a rare, genetic muscle disorder defined on the basis of muscle dysfunction an...

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Disputationen: 7.11.2014

Väittämistaakka, tuomarin kyselyvelvollisuus ja pakottavaan yksityisoikeudelliseen sääntelyyn perustuvien vaatimusten tutkiminen siviiliprosessissa

Jari Vaitoja

The subject of this study is the various responsibilities of the parties and the court concerning the restriction and presentation of factual grounds for civil litigation claims and denials. Special focus is placed on grounds that are regulated by mandatory private law rules. The investigation of civil cases is at the initiative of the interested parties, who are obliged to invoke so cal...

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Disputationen: 7.11.2014

On Governance of Quality Shipping in the Baltic Sea : Exploring Collective Action in Polycentric Contexts

Daria Gritsenko

This dissertation aims at clarifying how multiple public and private decision-making actors co-exist in the governing of shipping quality in the Baltic Sea, and which mechanisms allow these multiactor arrangements to proliferate and sustain themselves. Acknowledging that collective action problems undermine quality governance, this research sought to collect empirical evidence documentin...

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Disputationen: 8.11.2014

Responding in overlap : Agency, epistemicity and social action in conversation

Anna Vatanen

This study examines overlapping talk in naturally occurring interaction by focusing on the social actions that are accomplished through both the overlapping and the overlapped turns with the aim of determining the motivation for early turn-onset. The focus is on the agreeing non-minimal responding turns that start up in overlap at a point that is not a transition relevance place, that is...

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Disputationen: 8.11.2014

Muutos Perniön rovastikunnasta Salon seurakunnaksi : kieltämisen kautta hyväksyntään

Susa Niinistö

The parishes in the Finnish Evangelical-Lutheran church in Finland work today among many overlapping changes. The needs for these changes have arisen from the parishes governance and structural change needs as well as from rural development (i.e., joining smaller rural counties into bigger counties). Rural development and the related growth in scale have a direct impact on parish structu...

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Disputationen: 8.11.2014

Systematic Analysis of disease pathways in Congenital, Infantile and Juvenile Neuronal Ceroid Lipofuscinoses

Enzo Scifo

Neuronal ceroid lipofuscinoses (NCL) are common inherited childhood brain disorders. Since 1995, 13 known NCL causative genes (CLN1-8, CLN10-14) have been identified. Despite progress in the NCL field, the primary function and physiological roles of most NCL proteins remain unresolved. In this thesis, we utilized various techniques, such as: functional proteomics, bioinformatics, and mou...

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Disputationen: 12.11.2014

Obesity, weight change and work disability - a follow-up study among middle-aged employees

Eira Roos

Obesity and overweight are common among working aged population. Obesity is associated with a number of long-term illnesses as well as increased mortality. Previous studies have found that obesity is also associated with some forms of work disability. However, longitudinal studies with register-based large data sets are scarce. The aim of this study was to examine the association between...

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Disputationen: 13.11.2014

In Search of Health-Promoting Microbes: In Vitro and In Vivo Studies in Swine

Tanja Lähteinen

Lactobacilli are important members of the commensal microbiota of both man and animals, contributing to the health and well-being of the host. Dietary supplementation with lactobacilli to enhance the health and productivity of the host has generated much interest in the production animal sector, especially after the prohibition of in-feed antimicrobials. In the swine rearing industry, di...

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Disputationen: 14.11.2014

Cellular differentiation in the inner ear: The role of the network of transcription factors and the Rho GTPase Cdc42

Anna Kirjavainen

Development of the sensory epithelia of the inner ear and their primary cell types, hair cells and supporting cells, is a complex process under tight molecular regulation. These cells arise from common progenitors that are guided to follow cell-type-specific differentiation program, and undergo prominent structural changes to reach mature morphologies. The mechanisms regulating this cell...

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Disputationen: 14.11.2014

Role of CYP2C8 in the metabolism of montelukast and imatinib : Studies in vitro, in silico and in humans

Anne Filppula

The drug-metabolising enzyme cytochrome P450 (CYP) 2C8 is involved in the elimination of several important drugs. The asthma drug montelukast inhibits CYP2C8 potently in vitro, but does not affect the pharmacokinetics of CYP2C8 substrates in vivo. In turn, the cancer drug imatinib is a CYP2C8 and CYP3A4 substrate in vitro, but CYP3A4 inhibitors have little effect on its concentrations in...

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Disputationen: 14.11.2014

The influence of seasonal sea ice on the physics of the coastal waters - Gulf of Finland

Ioanna Merkouriadi

The Gulf of Finland is located in the seasonal sea ice zone (SSIZ), were sea ice forms in the wintertime and melts in late spring. This seasonality entitles this sea as a key area regarding the impact of climatic changes. When the basin of interest is located at the climatological edge of the SSIZ, there is also high inter-annual variability in the ice conditions. The aim of this study w...

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Disputationen: 14.11.2014

Microvascular dysfunction in ischemia-reperfusion in cardiac and kidney allografts

Raimo Tuuminen

Transplant ischemia/reperfusion injury (Tx-IRI) remains among the major clinical challenges in organ transplantation. Tx-IRI may result in deleterious short-term consequences such as primary graft dysfunction and increased immunogenicity of the allograft, both of which enhance the propability for late vascular remodeling and fibroproliferative processes, ultimately leading to untreatable...

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Disputationen: 14.11.2014

Finnish primary school pupils performance in learning to learn assessments : A longitudinal perspective on educational equity

Mari-Pauliina Vainikainen

During the last decade, Finnish pupils performance in educational assessment studies has steadily declined. At the same time the differences between pupils and in the capital area also the differences between schools have increased, and girls usually outperform boys in most assessed domains. The aim of the present study was to examine how these differences develop during primary educatio...

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Disputationen: 14.11.2014

AMIGO and its friends in developing and adult brain

Juha Kuja-Panula

The purpose for this PhD research is to find a novel gene induced by neurite outgrowth on amphoterin substrate. The finding was a gene that codes type-I transmembrane protein with six leucine-rich repeat (LRR) motifs and one immunoglobulin domain followed by a short cytoplasmic tail. We named this gene as amphoterin-induced gene and ORF (Amigo). Further characterization of AMIGO protein ...

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Disputationen: 14.11.2014

Kirkko muistiyhteisönä : Järvenpään seurakunnan messujen muistiyhteisöluonne

Anneli Vartiainen

The study investigated how the character of a worship service s community of memory was manifested in the Parish of Järvenpää s worship services. The theoretical background was Robert N. Bellah and colleagues views on the community of memory and its foundational elements. The study sought to determine the community of memory s fundamental elements including the constitutive narrative and...

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Disputationen: 15.11.2014

Multimodal Representation and Intermodal Similarity - Cues of Space in the Audio Description of Film

Maija Hirvonen

The present dissertation analyses the representation of space in filmic audio description. The main objective of this study is to shed light on two critical challenges for audio description: (1) how the filmic space becomes audible in audio-described film through spoken language, sound effects, and music, and (2) how the visual representation of space in film can be cued by the linguisti...

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Disputationen: 15.11.2014

Intermolecular protein splicing and its use in biotechnological applications

A. Sesilja Aranko

Inteins are selfish but harmless autocatalytic proteins that perform a post-translational modification, termed protein splicing. In protein splicing an intein excises itself off from the precursor protein and simultaneously ligates the flanking proteins together with a peptide bond. Inteins are found sporadically distributed in unicellular organisms, but their biological functions remain...

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Disputationen: 18.11.2014

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Nestekromatografia-massaspektrometria -menetelmä lääkeaineiden ja ympäristökemikaalien välisten metabolisten yhteisvaikutusten tutkimiseen

Kallio, Arttu / 31.10.2014

Nestekromatografia-massaspektrometria -menetelmä lääkeaineiden ja ympäristökemikaalien välisten metabolisten yhteisvaikutusten tutkimiseen Kallio, Arttu Tärkeimpiä vierasaineita metaboloivia entsyymejä elimistössä ovat sytokromi P450 (CYP) -entsyymit. Koska useat vierasaineet metaboloituvat keskenään samojen CYP-entsyymien kautta, on niiden välilä mahdollista tapahtua metabolisia yhteisv...

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Reppureissaajien tietotekniikan käyttö ja asenteet

Leppälä, Aleksi / 30.10.2014

Reppureissaajien tietotekniikan käyttö ja asenteet Leppälä, Aleksi The aim of the research is to solve backpackers IT usage, how they use it and what are their attitudes towards it in a personal and society level. The targets of the study are backpackers who live in a western society and the aim is to investigate what is the role of IT during their travel compared to everyday life. In su...

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Uskonto ja arvokysymykset Yhdysvaltain republikaanisen puolueen politiikassa 2009-2012

Tiitinen, Anni Marleena / 30.10.2014

Uskonto ja arvokysymykset Yhdysvaltain republikaanisen puolueen politiikassa 2009-2012 Tiitinen, Anni Marleena Vuonna 2009 Yhdysvaltain republikaaninen puolue oli kriisissä joutuessaan ensimmäistä kertaa 2000-luvun aikana oppositioasemaan. Republikaanit olivat menettäneet valta-asemansa ja Yhdysvallat näytti olevan presidentti Barack Obaman ja demokraattienemmistöisen kongressin johdolla...

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Mikä on energia- ja kasvuturpeen elinkaaren ilmastovaikutus?

Pohjala, Maria / 29.10.2014

Mikä on energia- ja kasvuturpeen elinkaaren ilmastovaikutus? Pohjala, Maria Turvetoimialan toiminnassa turvetuotteiden ilmastovaikutuksen määrittäminen ja kasvihuonekaasu (KHK) -päästöjen vähentämismahdollisuuksien selvittäminen ovat olennaisessa roolissa. Energiaturpeen ilmastovaikutusta on selvitetty paljon käyttäen menetelmänä elinkaarianalyysiä, mutta arviot tutkimusten kesken vaihte...

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