Suomeksi |  På svenska |  In English

Bläddra eller sök avhandlingar

The establishment of efficient methods to culture immunosuppressive mesenchymal stromal cells from cord blood and bone marrow

Anita Laitinen

Mesenchymal stem/stromal cells (MSCs) are multipotent cells that can be found in various tissues. These cells have the capacity to differentiate into bone, adipose, and cartilage. They also have the capacity to suppress immune reactions and the capacity to support angiogenesis. The utilization of these cells in cell based therapies has therefore been intensively studied. There are severa...

Läs avhandlingen »

Disputationen: 26.8.2016

Severe acute pancreatitis - Predicting with ecto-5'-nucleotidase (CD73) and treatment with activated protein C

Lea Kyhälä

Acute pancreatitis (AP) is a common abdominal disease with no specific treatment. The clinical manifestation of AP can vary widely from a mild self-limiting disease to a potentially life-threatening severe form. Severe acute pancreatitis (SAP) develops in about 20-25% of patients with AP, and the severe disease is associated with the development of such complications as pancreatic necros...

Läs avhandlingen »

Disputationen: 26.8.2016

Enzymatic plant cell wall degradation by the white rot fungus Dichomitus squalens

Johanna Rytioja

Basidiomycete white rot fungi are wood-rotting species and their impact to the global carbon cycle is significant. White rot fungi are capable of degrading all the polymeric cell wall components of the plant biomass from polysaccharides, cellulose, hemicelluloses and pectin, to the aromatic heteropolymer lignin. This is due to their ability to produce diverse set of extracellular enzymes...

Läs avhandlingen »

Disputationen: 26.8.2016

Chronic Myeloid Leukemia Patients’ Adherence to Tyrosine Kinase Inhibitors in Finland: A Journey of Eighty-six Patients

Meri Kekäle

The establishment of tyrosine kinase inhibitors (TKIs) has revolutionized the treatment of chronic myeloid leukemia (CML) during the last fifteen years. This study explored the journey of 86 patients with CML using oral TKI treatment in Finland. The aim was to assess their adherence to TKIs and how the adherence, which is crucial for treatment outcomes, could be improved.

Läs avhandlingen »

Disputationen: 26.8.2016

X-Ray Scattering Studies of Biological and Biomimetic Materials

Inkeri Kontro

Elastic X-ray scattering is a probe which provides information on the structure of matter in nanometer lengthscales. Structure in this size scale determines the mechanical and functional properties of materials, and in this thesis, small- and wide-angle X-ray scattering (SAXS and WAXS) have been used to study the structure of biological and biomimetic materials. WAXS gives information on...

Läs avhandlingen »

Disputationen: 26.8.2016

Convergence rates and uncertainty quantification for inverse problems

Hanne Kekkonen

My dissertation focuses on the convergence rates and uncertainty quantification for continuous linear inverse problems. The problem is studied from both deterministic and stochastic points of view. In particular, I considered regularisation and Bayesian inversion with large noise in infinite-dimensional settings.

Läs avhandlingen »

Disputationen: 26.8.2016

New Insights into the Biogenesis of Lactobacillus rhamnosus GG Pili and the In Vivo Effects of Pili

Pia Rasinkangas

The present thesis studied the biogenesis of the pili of Lactobacillus rhamnosus GG, and examined whether pili influence the in vivo persistence and the ability to modulate faecal microbiota in mice and humans. L. rhamnosus GG is one of the most extensively studied lactic acid bacteria, and it is commonly present in so-called probiotic products. Heterotrimeric proteinaceous pili, which a...

Läs avhandlingen »

Disputationen: 26.8.2016

Samapalkkaisuus - neuvoteltu oikeus - Naisten ja miesten palkkaeriarvoisuus poliittisena ja oikeudellisena kysymyksenä korporatistisessa Suomessa

Milja Saari

Miksi sukupuolten palkkaeron pienentäminen on niin vaikeaa? Miksi velvoitteita tasa-arvosuunnitelmien ja palkkakartoituksien laatimiseen laiminlyödään työpaikoilla? Miten oikeistokonservatiivinen käänne näkyy samapalkkaisuuden politiikassa? Näihin kysymyksiin etsitään vastauksia tässä väitöskirjassa, joka koostuu viidestä artikkelista ja yhteenvetoluvusta. Samapalkkaisuutta tutkitaan tas...

Läs avhandlingen »

Disputationen: 27.8.2016

Constrained life chances: Intergenerational transmission of income in Finland

Outi Sirniö

The resources possessed by one generation have a substantial impact on the life chances of the following generation. Parental material, social, and cultural resources influence children s educational attainment and occupational career paths. This study provides new information about socioeconomic attainment by concentrating on income ranking, especially the lowest and highest income leve...

Läs avhandlingen »

Disputationen: 2.9.2016

Impact of technological change on quality of care: studies on total hip and knee replacement

Mikko Peltola

This thesis analysed the impact that the introduction of new technology may have on the quality of care in a hospital setting. Technological change in medicine is rapid, as new devices are constantly taken into use in patient care, and new methods of delivering the care to patients are introduced, replacing existing routines and creating new practices all with the aim of benefitting pati...

Läs avhandlingen »

Disputationen: 2.9.2016

Changing institutions and consumer-driven development of forest products and services

Jani Holopainen

The forest sector has been able to develop many new bio-based and sustainable products catered to business-to-business markets, but the sector still lacks a breakthrough in new forest products and services targeting consumer markets. This is due to higher prices of forest products compared to competing materials, such as concrete, steel, and plastics, but also due to a lack of new produc...

Läs avhandlingen »

Disputationen: 2.9.2016

ESSAYS ON DIRECTIONAL PREDICTABILITY OF FINANCIAL AND ECONOMIC TIME SERIES

Harri Pönkä

This thesis is a collection of four self-contained essays that discuss time series applications of binary response models. Although popular in microeconometric applications using cross-sectional data, this class of models is not among the most commonly used ones in time series econometrics. Nevertheless, these models hold interesting possibilities to various forecasting issues in empiric...

Läs avhandlingen »

Disputationen: 2.9.2016

Genetic and environmental control of flowering in wild and cultivated strawberries

Elli Koskela

Strawberries (Fragaria sp.) belong to the large family of Rosaceae that includes commercially important crop plants such as apple, pear, peach and roses. The economic impact of these species is huge and breeders around the world are striving to keep up with consumers' demands on novelty produce. At the same time, climate change is having an impact on the onset of flowering especially in ...

Läs avhandlingen »

Disputationen: 2.9.2016

Control of Listeria monocytoenes in the food industry

Riina Tolvanen

In this thesis contamination routes of L. monocytogenes were examined in a food establishment, the survival of L. monocytogenes strains was studied in dry-fermented sausages prepared using two different starter cultures, the acid and heat tolerance of L. monocytogenes strains were studied, and efficacy of ultrasonic cleaning was tested on conveyor belts contaminated with L. monocytogenes...

Läs avhandlingen »

Disputationen: 2.9.2016

Photochemical transformation of dissolved organic matter in aquatic environment - From a boreal lake and Baltic Sea to global coastal ocean

Hanna Aarnos

As dissolved organic matter (DOM) constitutes a vast reservoir of carbon and nutrients in lakes, rivers and ocean, it plays an important role in the global carbon and nutrient cycles. Only a part of DOM is directly biologically utilizable by bacteria, but solar radiation induced photochemical reactions may mineralize DOM to inorganic forms such as dissolved inorganic carbon (DIC) and amm...

Läs avhandlingen »

Disputationen: 2.9.2016

Vaikenemisia ja vastarintaa - Valtasuhteet ja toiminnan mahdollisuudet oppilaitosten tasa-arvosuunnittelussa

Elina Ikävalko

Tarkastelen tutkimuksessani henkilöstöpoliittisen ja toiminnallisen tasa-arvosuunnittelun käytäntöjä toisen asteen oppilaitoksissa, etenkin tasa-arvotyötä varten perustetuissa tasa-arvotyöryhmissä. Tarkastelen oppilaitoksia sekä opiskelu- että työpaikkoina ja teen näkyväksi sukupuolten tasa-arvon tavoittelun käytäntöjä, joilla julkilausutuista tavoitteista huolimatta saattaa olla myös er...

Läs avhandlingen »

Disputationen: 2.9.2016

Kenen Aleksi, sen Helsinki - Kluuvin kävelykatutaistelut 1968 - 2003

Janne Viitamies

Yhtenä tutkimukseni johtopäätöksenä on, että Helsingin kävelykeskusta laajenee, kun autoliikenteen nopeutta hillitään ja jalankulkutilaa lisätään, mutta ei siten, että autoilu pyrittäisiin täysin kieltämään. Kaupunki määritteli jalankulkemisen ydinkeskustan tärkeimmäksi kulkumuodoksi jo 1970-luvun alussa. Silti Kluuvin nykyinen kävelykeskusta muodostui ristiriitojen jälkeen vasta 1990-lu...

Läs avhandlingen »

Disputationen: 2.9.2016

Mer »

MetaFlow: Metagenomics taxonomic analysis using network flows

Sobih, Ahmed / 17.08.2016

MetaFlow: Metagenomics taxonomic analysis using network flows Sobih, Ahmed Our planet is pervaded by hundreds of millions of microorganisms that are not visible to the naked eye. These microorganisms, also known as microbes, include bacteria, archaea, fungi, protists and viruses. Metagenomics allows for the study of microbial samples collected directly from the environment without prior ...

Läs avhandlingen »

Measuring a HTML5 Hybrid Application's Native Bridge on iOS

Paksula, Matti / 17.08.2016

Measuring a HTML5 Hybrid Application's Native Bridge on iOS Paksula, Matti Mobile apps are intended to be created with mobile platforms development tools and programming languages. This native development requires specialized skills and can therefore be prohibitively expensive. HTML5 hybrid app development is a popular alternative for native mobile app development. This development model...

Läs avhandlingen »

A Variant of the Multiple Random Projection Trees Algorithm for Nearest Neighbors Search

Tuomainen, Risto Olli Oskari / 17.08.2016

A Variant of the Multiple Random Projection Trees Algorithm for Nearest Neighbors Search Tuomainen, Risto Olli Oskari In nearest neighbors search the task is to find points from a data set that lie close in space to a given query point. To improve on brute force search, that computes distances between the query point and all data points, numerous data structures have been developed. Thes...

Läs avhandlingen »

Event detection in interaction network

Xiao, Han / 17.08.2016

Event detection in interaction network Xiao, Han; Xiao, Han We study the problem of detecting top-k events from digital interaction records (e.g, emails, tweets). We first introduce interaction meta-graph, which connects associated interactions. Then, we define an event to be a subset of interactions that (i) are topically and temporally close and (ii) correspond to a tree capturing info...

Läs avhandlingen »

Mer »