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Magnetic resonance-guided high-intensity focused ultrasound mediated mild hyperthermia and drug delivery

Ari Partanen

Ablative hyperthermia (more than 55 °C) has been used as a stand-alone treatment for accessible solid tumors not amenable to surgery, whereas mild hyperthermia (40-45 °C) has been shown effective as an adjuvant for both radiotherapy and chemotherapy. An optimal mild hyperthermia treatment is noninvasive and spatially accurate, with precise and homogeneous heating limited to the target re...

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Disputationen: 14.6.2013

Moved by the City : Experiences of Helsinki in Finnish Prose Fiction 1889-1941

Lieven Ameel

This study analyses experiences of Helsinki in prose fiction published in Finnish in the period 1889-1941. It examines the relationships that are formed between Helsinki and fictional characters, focusing, especially, on the way in which urban public space is experienced. Particular attention is given to the description of movement through urban space. The primary material consists of mo...

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Disputationen: 14.6.2013

Sticky business : diversity and evolution of Mycocaliciales (Ascomycota) on plant exudates

Hanna Tuovila

Species of Mycocaliciales are a group of small ascomycetes with pin-like ascocarps. Among Fungi, many mycocalicioid species are rather unique in having specialized to live on the resinous exudates of vascular plants. Terpenoid and phenolic resins essentially are repellents for fungi, but some of these species even appear to use resins for their nutrition. This peculiar ecology has a long...

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Disputationen: 14.6.2013

Deontic rights in interaction : A conversation analytic study on authority and cooperation

Melisa Stevanovic

This dissertation describes people s orientations to "deontic rights" -that is, their rights to determine actions. Through analyses of video-recorded church workplace meetings between pastors and cantors as data, and conversation analysis as a theoretical and methodological framework, the study examines how participants in interaction may establish their own and each other s deontic righ...

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Disputationen: 14.6.2013

Maximizing peatland forest regeneration success at lowest cost to the atmosphere: Effects of soil preparation on Scots pine seedling vitality and GHG emissions

Meeri Pearson

This dissertation investigated the impacts of soil preparation after clearcutting Scots pine (Pinus sylvestris L.) forest on thick-peated soil from silvicultural and climatic standpoints. Three growing seasons after outplanting, mounding most effectively secured seedling survival, growth, and vitality through improved soil aeration of the planting spot. However, other presumed benefits o...

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Disputationen: 14.6.2013

Development of high-throughput yeast-cell-based bioreporter assays for specific monitoring of bisphenol A and chemical testing of endocrine disrupting compounds

Johanna Rajasärkkä

Chemicalization of the modern society has become a topic of debate in the past few decades. Especially chemicals that affect the human reproduction and hormonal system, the so-called endocrine disrupting compounds, have raised concern in public and regulatory agencies. There is a growing need for suitable testing methods to screen endocrine disrupting potential of new and old chemicals. ...

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Disputationen: 14.6.2013

Radiographic Screening for Hereditary Skeletal Disorders in Dogs

Anu Lappalainen

Screening in dog breeding refers to testing or examining individuals for hereditary diseases or faults. Results can help dog breeders in decision-making when selecting breeding material. Radiographic screening for canine elbow dysplasia (ED) began several decades ago, but genetic improvements have been modest. Several reasons for slow progress exist; perhaps one of the most important is ...

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Disputationen: 14.6.2013

Surgical Reconstruction, Locally Recurrent Breast Cancer and Angiosarcoma

Andrew Lindford

Background: Local recurrence (LR) of breast cancer is defined as any recurrence of tumour in the ipsilateral thoracic wall and locoregional recurrence (LRR) as any recurrence in the ipsilateral thoracic wall or regional lymph nodes following surgery for primary breast cancer. The standard of care for LRR has not been established but surgery forms a key part of most accepted strategies. T...

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Disputationen: 14.6.2013

Oral health in liver transplant recipients

Jaana Helenius-Hietala

Liver transplantation (LT) is the treatment of choice for patients with severe liver disease. Quality of life of patients after LT may be comparable to that of the general population, but permanent immunosuppression poses a high risk for infections. Highly prevalent dental diseases not promptly treated may compromise LT outcome. All possible infectious foci, including dental infections, ...

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Disputationen: 14.6.2013

Taidelähtöiset menetelmät lastensuojelussa : kohti tilaa ja kokemuksia

Päivi Känkänen

Tutkimuksen intressinä on ollut halu tarkastella ja analysoida uusia lähestymistapoja ja toimintamalleja lastensuojeluun taideperustaisen tutkimusstrategian avulla. Lähtökohtaisena ajatuksena on ollut, että ratkaisut lastensuojelun pulmiin ja työmenetelmien kehittämiseen eivät löydy vain lastensuojelun vakiintuneiden ja vallitsevien käytäntöjen sisältä, vaan eri lähestymistapojen, toimin...

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Disputationen: 15.6.2013

The Bilingual Screen : Ethnolinguistic identity and television viewing among three language minorities

Laszlo Vincze

The purpose of the present study was to examine the relationship between ethnolinguistic identity and television viewing among minority language speakers. Inspired by the model proposed by Abrams, Eveland and Giles (2003), and Reid, Giles and Abrams (2004), the study integrated ethnolinguistic identity theory (Giles and Johnson, 1981, 1987), uses and gratifications approach (Katz, Blu...

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Disputationen: 15.6.2013

The spatio-temporal evolution of the Asian monsoon climate in the Late Miocene and its causes: A regional climate model study

Hui Tang

Late Miocene (11-5 Ma) is a crucial period for Asian monsoon evolution. Significant changes of both the India and East Asian monsoons in this period have been documented in geological records. In this study, a high-resolution regional climate model COSMO-CLM driven by a fully coupled atmosphere-ocean general circulation model ECHAM5/MPI-OM is employed to investigate the monsoon climate c...

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Disputationen: 15.6.2013

Non-smooth curvature and the energy of frames

Jan Cristina

This thesis studies connections and frames with very little regularity. It developed as a study of the Cartan-Whitney presentations of Heinonen and Sullivan, and the Quasiconformal frames of Heinonen, Pankka and Rajala. The thesis consists of three chapters of which the first is the introduction. The second chapter is devoted to the development of a theory of non-smooth connections on...

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Disputationen: 15.6.2013

Modeling key processes causing climate change and variability

Svante Henriksson

Greenhouse gas warming, internal climate variability and aerosol climate effects are studied and the importance to understand these key processes and being able to separate their influence on the climate is discussed. Aerosol-climate model ECHAM5-HAM and the COSMOS millennium model consisting of atmospheric, ocean and carbon cycle and land-use models are applied and results compared to m...

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Disputationen: 15.6.2013

Auditory perceptual learning in musicians and non-musicians : Event-related potential studies on rapid plasticity

Miia Seppänen

Music training shapes functional and structural constructs in the brain particularly in the areas related to sound processing. The enhanced brain responses to sounds in musicians when compared to non-musicians might be explained by the intensive auditory perceptual learning that occurs during music training. Yet the relationship between musical expertise and rapid plastic changes in brai...

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Disputationen: 17.6.2013

Toiseuksien rakentuminen koulussa : Tutkimus opetussuunnitelmista ja kahden helsinkiläisen alakoulun arjesta

Anna-Leena Riitaoja

In my study I research how differences and Otherness are constructed in curriculum texts and in everyday practices in two Finnish public primary schools. The data consist of Finnish National Core Curriculum texts for basic education written in 1970, 1985, 1994 and 2004, interviews from two authorities who served on the National Board of Education in 2007 and ethnographic observation and ...

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Disputationen: 19.6.2013

Variation of the PALB2 and PTEN Genes and eIF4E Protein Expression as Prognostic Factors in Breast Cancer

Tuomas Heikkinen

Breast cancer is the most common cancer in women and the leading cause of female cancer mortality. Family history is one of the major risk factors for breast cancer, and the hereditary factors also play a role in breast cancer survival. Investigation of the inherited variants for breast cancer risk, tumor phenotype, and prognosis can be beneficial for further improvements of clinical man...

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Disputationen: 19.6.2013

Survival and reduction of strains of Campylobacter species in broiler meat

Pauliina Isohanni

Campylobacter, especially Campylobacter jejuni and C. coli, are reported as the most frequent cause of foodborne bacterial diarrhoea in humans worldwide. One of the most important sources of human campylobacteriosis is the eating or handling of improperly cooked or raw broiler meat.

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Disputationen: 19.6.2013

From cell surface to nucleus: Unraveling cancer metastasis and the role of nucleophosmin in breast cancer

Piia-Riitta Karhemo

The most deadly aspect of cancer is its ability to spread from its original location to other sites in the body and grow as distant metastases. Formation of metastases is a multistep process and metastases can form even decades after the removal of the primary tumor. Cell surface proteins are known to play central roles in the adhesive contacts and molecular interactions between the tumo...

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Disputationen: 19.6.2013

Dislocation mechanisms leading to protrusion growth under electric field induced stress on metal surfaces

Aarne Pohjonen

The work presented in this thesis is related to the design of the future electron-positron collider, called the Compact Linear Collider (CLIC), which is currently under development at CERN. The designed operation of the collider requires accelerating electric field strengths of ∼ 100 MV/m range to reach the target energy range of 0.5 to 5 TeV for the collisions in a realistic and cost ef...

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Disputationen: 20.6.2013

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Developing a Consistent and Unbiased Index for Timberland Returns

Äärilä, Johannes / 17.06.2013

Developing a Consistent and Unbiased Index for Timberland Returns Äärilä, Johannes This thesis investigates the methods and principles used to calculate timberland return indi-ces. By studying these existing indices and new possible methods, the study contributes to the accuracy and methodology of timberland return measurement. Attention towards timberland investing has been increasi...

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Rakennusalan työaikainen ruokailu osana työhyvinvointia

Salminen, Päivi / 17.06.2013

Rakennusalan työaikainen ruokailu osana työhyvinvointia Salminen, Päivi Rakennusalalla työaikaisen ruokailun järjestäminen on ollut vähäisempää kuin muilla aloilla. Rakennusala on fyysisesti raskasta työtä ja työntekijä tarvitsee ravintoa jaksaakseen ja pitääkseen yllä hyvän vireystason. Työaikainen ruokailu on aina ollut merkittävässä asemassa ihmisten arjessa, mutta se huomioidaan harv...

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Nurmen täydennyskylvön vaikutus kasvustoon ja nurmijyräyksen kannattavuuden arviointi

Luukkonen, Vesa / 17.06.2013

Nurmen täydennyskylvön vaikutus kasvustoon ja nurmijyräyksen kannattavuuden arviointi Luukkonen, Vesa Suomessa nurmien sadontuotto alenee yleensä jo kolmannen satovuoden jälkeen ja suurin osa viljelynurmista uudistetaan alle viisi vuotta vanhoina. Nurmikasvustot kärsivät talvesta, sekä nurmen korjuun ja laiduntamisen aiheuttamasta rasituksesta. Kasvustoon syntyy aukkoja, jolloin sato ale...

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Finnish Mechanical Forest Industry SME Perceptions of Export Barriers to Russia

Pirttilahti, Maria / 17.06.2013

Finnish Mechanical Forest Industry SME Perceptions of Export Barriers to Russia Pirttilahti, Maria This Master’s Thesis studies the main barriers in exporting forest products from Finland to Russia. The barriers are studied on three levels: the home market in Finland, the host market in Russia, and the internal resources and organization of the firms. In addition, the perceptions of indu...

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