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Novel Detector Technologies for Medical Applications at the Example of Tumor Detection in BNCT

Alexander Winkler

The next evolutionary step in medical imaging and radiation therapy is to employ novel detector technologies capable of photon counting operations. These detectors allow to acquire the spectrum of the radiation for each pixel. Currently used energy integrating detectors do not allow this. Two types of detector materials capable of photon counting operation are discussed in this work. Wit...

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Public examination: 20.10.2017

Urine testing and abuse patterns of drugs and new psychoactive substances - Application of comprehensive time-of-flight mass spectrometry

Mira Sundström

In Finland, the number of problem opioid and amphetamine users lies between 18,000 and 30,000, whereby only 20% receive treatment for their dependence. Annually illicit or medicinal drugs are found in the blood samples of more than 6,000 drivers, and approximately 500 fatal poisonings result from drugs. Drug testing attempts to unravel the role of psychoactive substances—whether used for...

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Public examination: 20.10.2017

Phosphorus in the sediment of agricultural constructed wetlands

Johanna Laakso

Phosphorus (P) losses from agricultural soils impair the quality of receiving surface waters by enhancing eutrophication. Most of the P carried by surface runoff and field drainage waters from clay soils in SW Finland is in particulate form, but more than half of the total P is potentially bioavailable. Thus, decreasing the load of suspended particles is important in controlling eutrophi...

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Public examination: 20.10.2017

Modelling the twin-cam compound bow

Marko Tiermas

In this thesis, the statics of the archery twin-cam compound bow is investigated with the help of mathematical models. The simplest case is the model of the round-wheel compound bow, which is then advanced with the Euler-Bernoulli (EB) beam model for the limb deformation. Further, a generalization of the round-wheel compound bow model is examined, and also the twin-cam compound bow with ...

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Public examination: 20.10.2017

Rethinking Recognition: Transnational Families and Belonging in Law

Sanna Mustasaari

This dissertation investigates how transnational family relationships come to assume legal character, how and for what purposes ‘legality’ is invoked; and analyses the ways in which the recognition of transnational family relationships generate belonging or non-belonging and how these belongings are constructed in legal practice and argumentation. Finally, it explores whether recognition...

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Public examination: 20.10.2017

The Relationship of EU Law and Bilateral Investment Treaties of EU Member States

Pekka Niemelä

This dissertation analyses the relationship of EU Law and International Investment Law from a number of different perspectives. These perspectives relate to two distinct debates that concern the future of investment treaties in Europe. The first debate relates to the formal relationship of EU law and bilateral investment treaties (BITs) of EU member states. The Commission has argued that...

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Public examination: 25.10.2017

Bioinformatic solutions for chromosomal copy number analysis in cancer

Ilari Scheinin

Chromosomal copy number aberrations are one of the main mechanisms that give rise to the proliferative capabilities of cancer cells. These aberrations can be quantified with technologies that generate measurements genome-wide and with high resolution. Hence, they produce vast amounts of data, which requires tailored bioinformatic solutions for analysis and management. Two such high-resol...

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Public examination: 27.10.2017

TYROSINE KINASE INHIBITION IN EXPERIMENTAL KIDNEY TRANSPLANTATION

Jukka Rintala

Chronic allograft injury is a multifactorial process mediated by both immunological and non-immunological factors, leading to organ dysfunction and humoral and cellular rejection. Currently, no specific treatment is available for chronic allograft injury. Pathological growth factor expression is observed before the development of end-stage renal disease (ESRD), and several growth factors...

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Public examination: 27.10.2017

Imitation of biologically relevant oxidation reactions by titanium dioxide photocatalysis: Advances in understanding the mimicking of drug metabolism and the oxidation of phosphopeptides

Miina Ruokolainen

Redox reactions play an important role in human physiology and pathophysiology. For example, oxidative stress and free radical-mediated oxidation of proteins and lipids are implicated in several diseases such as Alzheimer’s and Parkinson’s disease. Oxidation reactions belong also to the most important phase I metabolism pathways of drugs, which can give rise to pharmacologically active o...

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Public examination: 27.10.2017

Categorical representations of phonemic vowels investigated with fMRI

Kirsi Harinen

The present thesis investigates the sensitivity of the human auditory cortex (AC) to the contrast between prototype and nonprototype vowels as well as between phonemic and nonphonemic vowels. Activations to vowels were measured with functional magnetic resonance imaging (fMRI), which was also used to analyze the effect of categorical processing on modulations in AC and adjacent inferior ...

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Public examination: 27.10.2017

Identification and Characterization of Yersinia from Food and Environmental Sources

Anna Murros

Yersinia genus includes currently 18 species: Yersinia pestis, Yersinia pseudotuberculosis, Yersinia enterocolitica, Yersinia frederiksenii, Yersinia intermedia, Yersinia kristensenii, Yersinia bercovieri, Yersinia mollaretii, Yersinia rohdei, Yersinia ruckeri, Yersinia aldovae, Yersinia aleksiciae, Yersinia massiliensis, Yersinia similis, Yersinia entomophaga, Yersinia nurmii, Yersinia ...

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Public examination: 27.10.2017

Bayesian cluster analysis with applications to pathogen population genomics

Alberto Pessia

Identifying similarity patterns in heterogeneous observations is a very common problem in many branches of science. When the similarities and dissimilarities are encoded by a group structure, the task of dividing the observed sample into an unknown number of homogeneous groups is known as cluster analysis. Among the many types of statistical data analyses, it is one of the most widely ap...

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Public examination: 27.10.2017

Plant biomass-acting enzymes produced by the ascomycete fungi Penicillium subrubescens and Aspergillus niger and their potential in biotechnological applications

Sadegh Mansouri

Plant biomass contains complex polysaccharides that can be divided into structural and storage polysaccharides. Plant biomass is a major carbon source utilized by chemoheterotrophic microorganisms, such as filamentous fungi to grow and produce energy. Plant biomass-degrading fungi secrete a wide range of extracellular enzymes to convert complex plant biomass into metabolizable compounds....

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Public examination: 27.10.2017

Non-alcoholic fatty liver disease - studies on pathogenesis and diagnosis

Elina Isokuortti

Non-alcoholic fatty liver disease (NAFLD) often coexists with obesity and metabolic syndrome and is characterised by insulin resistance (IR). NAFLD may also be due to common gene variants in PNPLA3 at rs738409 and TM6SF2 at rs58542926. It is unclear whether these forms of NAFLD are related to IR. Liver fat content may be assessed using liver histology, imaging tools or biomarkers. This t...

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Public examination: 28.10.2017

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AGGREGAATTORIT ÄÄNITTEIDEN DIGITAALISESSA JAKELUSSA Tekijänoikeuslainsäädännön ja verotuksen näkökulmasta

Laine, Annina / 27.04.2017

AGGREGAATTORIT ÄÄNITTEIDEN DIGITAALISESSA JAKELUSSA Tekijänoikeuslainsäädännön ja verotuksen näkökulmasta Laine, Annina Tiivistelmä/Referat – Abstract Internet ja digitaalitekniikan kehitys on mullistanut musiikkialaa merkittävästi ja huomattava osa äänitteistä siirtyy nykyään kuuntelijalle digitaalisessa muodossa. Kuluttajille äänitemarkkinoiden digitalisoituminen merkitsee, että mus...

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Kartellivahingon määrän todistaminen vahingonkorvausoikeudenkäynnissä

Korhonen, Sofie / 27.04.2017

Kartellivahingon määrän todistaminen vahingonkorvausoikeudenkäynnissä Korhonen, Sofie Tiedekunta/Osasto Fakultet/Sektion – Faculty Oikeustieteellinen tiedekunta Laitos/Institution– Department Tekijä/Författare – Author Sofie Korhonen Työn nimi / Arbetets titel – Title Kartellivahingon määrän todistaminen vahingonkorvausoikeudenkäynnissä Oppiaine /Läroämne – Subject Oikeustalo...

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The Patent Economics of Synthetic Biology

Bützow, Alexander / 27.04.2017

The Patent Economics of Synthetic Biology Bützow, Alexander Kyseinen työ tutkii uutta bioteknologian muotoa, synteettistä biologiaa, ja sen suhdetta eurooppalaiseen immateriaalioikeuteen, erityisesti patenttioikeuteen. Tutkielman keskeiset kysymykset koskevat sen selvittämisestä, onko 1) synteettisen biologian keksinnöt systeemisesti soveltumattomia nykyiseen patenttioikeuteen, ja 2...

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Vastuun rajoittaminen asianajotoimeksiantosopimukseen perustuvan vastuunhallinnan keinona

Sotamaa, Rasmus / 27.04.2017

Vastuun rajoittaminen asianajotoimeksiantosopimukseen perustuvan vastuunhallinnan keinona Sotamaa, Rasmus Asianajajan mahdollisuuksiin rajata vastuutaan on perinteisesti suhtauduttu varovaisen torjuvasti niin Suomessa kuin muissakin Pohjoismaissa. Torjuvan suhtautumisen perusteet on usein liitetty asianajotoiminnan erityiseen luonteeseen. Vastuunrajoitukset on nähty erityisesti asianaja...

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