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Browsing by discipline "Psykologia"

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  • Benouaret, Sofia (2018)
    Autism spectrum disorder is associated to high rates of comorbid mental disorders, where depression is probably most common disorder. Although the high prevalence of depression in autism is well-known thing, relatively little is known about its underlying risk factors or explaining factors. This study aimed to examine whether there is evidence that some characteristic features of autism spectrum disorder would have an impact on high prevalence of depression in autism spectrum disorder. We discuss about two psychological factors: emotion regulation and its deficits and the tendency to perseverate and ruminate. Two factors related to perseveration, cognitive flexibility impairments and rumination were associated with depression and depression symptoms. The association between emotion regulation deficits and depression manifested in the use of maladaptive coping skills and in tendency to ruminate. More research is still needed to replicate these results and gain stronger evidence. The depression diagnosis in autism spectrum disorder is problematic in many ways, therefore all results concerning the subject should be interpreted with caution.
  • Ritvanen, Noora (2019)
    The goal of my thesis was to find out how personality affects the way people use social media and how social media profile information expresses people’s personality. I limited the studies involved to those in which personality was measured with same or similar inventories that are based on Big Five theory. The studies used were searched from Google Scholar and ScienceDirect databases with search statements ”Big Five” AND ”Social media”, Personality AND ”Social media” and Personality AND ”Social media use”. Extroverted people used social media for socializing and communication which was expressed through profiles for example as many connections to other people. Neurotic people used social media for communication and attention seeking. Neurotic people do not want to tell about their neuroticism to other people which might explain why neuroticism did not always have an association with behaviour in social media and why it was not expressed through profile information. People who are open to new experiences used social media for private communication. In profiles communication was expressed through broad networks. Openness to new experiences had incoherent association with using social media for gathering information. People who are high in conscientiousness used social media to support their social relations and for private communication. People who are high in conscientiousness do not want other people to see that they use social media because it is pointless which might explain why conscientiousness was not usually expressed through profile information. People who are high in agreeableness used social media for communication. Agreeableness is not associated with behaviour which can be seen in social media which might be the reason why agreeableness was not seen from profile information. Personality traits are expressed in social media profiles and behaviours in different ways which Big Five theory credibly explains.
  • Palo-oja, Peter (2016)
    Introduction: Sleep related problems affect wellbeing extensively. Sleep problems share many common background factors with personality, such as individual way of processing cognitions and emotions. By understanding the interactions between personality and sleep, it is possible to develop better and more individual-friendly ways to treat sleep related problems. In this review, personality is approached from the framework of the Big Five personality traits, which are: extraversion, neuroticism, conscientiousness, agreeableness, and openness. The purpose of this review is to sum up the current results of the research conducted in the field of personality traits and sleep, to direct the future research on the field and to discuss the limitations of the current research. Results: There are interactions between personality traits and sleep. Neuroticism affects the quality and the amount of sleep negatively. However, the causality might go the other way around: sleep deprivation and problems falling asleep might cause later neuroticism. Extraversion has a relationship with better quality of sleep, diminished amount of sleep and fluctuating circadian rhythm between weekdays and weekends. Conscientiousness affects the quality of sleep, the regularity of the circadian rhythm and the morningness of the circadian rhythm. Individuals who have high openness have diminished need for sleep and they have coping-mechanisms that protect them against the negative effects of stress. Agreeableness has a relationship with better sleep in terms of quality and quantity, and with constant circadian rhythm between weekdays and weekends. The personality traits’ interactions include conscientiousness’ protective effect against neuroticism when considering sleep quality. Also, the differences in sleep quantity are statistically best explained with two traits: openness and neuroticism. Discussion: The interaction between personality traits and sleep has been investigated mainly from the point of view of personality traits. When the interactions are studied from the point of view of sleep it is possible to merge the effects of the personality traits and derive preliminary personality trait profiles for different aspects of sleep. The profile for good quality of sleep seems to be high extraversion, high consciousness, high openness, high agreeableness, and low neuroticism. The profile for poor sleep quality is almost reverse: high neuroticism, low extraversion, low consciousness, and low openness. Apart from the quality, it’s also possible to derive subjective sleep deprivation profile: high neuroticism and low extraversion or interestingly high extraversion if only the amount of sleep is being studied. Limitations of the current research in the field include a tendency to use university student samples, self-assessment inventories as the sole information source and the over-simplifying approach of merely studying one personality trait instead of the whole personality profile. Examining the personality trait profiles could lead to more statistically significant results and thus it might increase the practical implications in the field of personality and sleep.
  • Kosola, Salla V. (2019)
    Background: Delirium is a common, under-diagnosed and serious problem among critically ill patients. Episodes of delirium are associated with a number of adverse outcomes; it seems to carry a considerable risk for future complications, increased future morbidity, long-term impairments in cognitive abilities, and even death. Approximately 80% of patients in intensive care unit (ICU) will develop delirium during their stay in hospital, making it to be a rather common condition – especially among elderly patients. With aging of the patient population in ICU incidence of delirium is likely to increase in future. Early recognition, prevention and treatment for delirium in and after ICU is extremely important for future recovery. There is promising evidence suggesting that delirium could be used as an effective tool for predicting future recovery and health complications after release from ICU. Aim of the study: To identify adverse consequences of post-operative delirium (POD) in ICU (with main focus on future cognitive decline), recognize possible risk groups and current screening and treatment procedures. Methods: A systematic review was conducted, following the Cochrane and Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Literature was collected between September and October 2019 from PubMed ja Ovid Medline data bases using keywords ’delirium’, ’critical illness’, ’consequences’, ’effects’,’cognitive decline’, and ’cognitive impairments’. The search yielded 23 peer reviewed articles which are included in this revies. Results: Episodes of non-dementia delirium in ICU were associated with a number of health complications, prolonged hospital stay and higher risk for readmissions, higher morbidity and mortality, increased risk of falls, accident and injuries, social problems, increased stress and distress, cognitive impairments and increased risk for developing dementia. Different subtypes of delirium (hypoactive vs. hyperactive) seemed to lead to somewhat different adverse consequences; however, all recognized subtypes were hazardous. Conclusions: Delirium is a common, severe and under-diagnosed health problem among ICU patients. It has shown to be associated with various adverse outcomes that create serious economical costs for both individuals and societies, as well as significantly impair patients’ health and later quality of life. Episodes of ICU delirium can cause cognitive impairments and accelerate cognitive decline associated with neuropsychiatric disorders (such as dementia). Although the majority of healthcare professionals acknowledge the severity of problem, the current procedures for prevention, treatment, screening and monitoring are severely lacking. Both current screening tools and training of medical staff are in dire need for improvements.
  • Kurko, Julia (2018)
    Depersonalization/derealization-symptoms are a subclass of dissociation symptoms. These symptoms are characterized by numbness of emotions, a feeling of being separated from one’s body, and a feeling of unreality of the outside world. The source of these symptoms is unclear at the moment. However, studies have shown that depersonalization/derealization symptoms can be caused by traumatic stress experiences. This raises the question of how depersonalization/derealization symptoms could be connected to daily, minor stress. Could daily stress also be an influencing factor on depersonalization/derealization symptoms? On the other hand, it could be that depersonalization/depersonalization experiences would cause a person to be more vulnerable to experiencing stress. In this review I take a closer look at the relationship between daily stress and depersonalization/derealization symptoms. It seems that a positive connection exists between depersonalization/derealization symptoms and daily stress. However, the direction of the connection remains unclear. There is some evidence depersonalization/derealization symptoms and daily stress often appear simultaneously. In addition, it seems that people who experience high amounts of depersonalization/derealization symptoms experience stress more intensely than the average person. Daily stress has also been shown to be a predictor of depersonalization/derealization symptoms when the effect of other psychopathology symptoms has been taken into account. The amount of other psychopathology seems to be an important moderator of the connection. All in all, the relationship between daily stress and depersonalization/derealization symptoms seems to be very complicated and more research is needed on this area.
  • Tarhonen, Rilla (2017)
    Depression is one of the most common psychological symptoms that often occurs with dementia. It can be a risk factor for dementia to develop, or it can also appear after dementia causes losses to a patient’s abilities. Depression has been shown to hinder the functional status of a patient with dementia even further. Using medication to treat depression in patients with dementia holds the risk of side effects. Instead, psychosocial treatments should be considered essential in the treatment of depression in dementia patients. The purpose of this review is to examine psychosocial treatments used for treating depression in patients with dementia. Of these treatments, psychotherapy, music therapy and reminiscence therapy are considered further. The evidence for psychotherapy, music therapy and reminiscence therapy is partly conflicting, but overall quite promising. In the future, more randomized controlled trials should be carried out, but there is also a need for qualitative studies to clarify which mechanisms enable treatments to affect depression in dementia patients.
  • Perälampi, Heidi (2018)
    Dissociation is defined as disruption in the normal integration of consciousness, memory, identity, emotion, perception, body representation, motor control, and behavior. The definition has some similarities with five symptom domains of schizophrenia; hallucinations, delusions, disorganized thinking, disorganized motor behavior, and negative symptoms. This review aims to clarify the relationship between dissociation and schizophrenia from three perspectives. These are; dissociative symptoms in schizophrenia patients; schizophrenia related symptoms in dissociative patients; and the correlation between schizophrenia related symptoms and dissociative symptoms. The most systematically studied area was dissociative symptoms in schizophrenia patients, and the results showed that schizophrenia patients do not have particularly high dissociative symptoms compared to other mental health disorders. In contrast schizophrenia related symptoms in patients with dissociative disorder diagnosis is somewhat understudied area; yet a very few studies have found connections particularly between dissociative disorders and auditory hallucinations. There seems to be relatively high correlation between schizophrenia related symptoms and DES-scores. Research evidence was compared to three theories that have tried to explain the relationship between dissociation and schizophrenia. The theory by Moskowiz, Read, Farrelly, Rudgeair and Williams, according to which all symptoms of schizophrenia, (possibly excluding negative symptoms) would be caused by dissociation, found no support. The duality model by Şar and Öztürk, and Ross’ and Keyes’ model of dissociative subgroup within schizophrenia, were not in conflict with research evidence. However, more research is needed for reliable evaluation of these models.
  • Vikman, Kira (2016)
    Aims Previous studies have shown that post-traumatic stress disorder (PTSD), borderline personality disorder (BPD) and schizophrenia resemble dissociative identity disorder (DID). Although symptoms in these disorders are similar, their treatment is not, which makes it important to reach for a correct diagnosis. The aim of this review is to clarify differential diagnosis in DID in relation to PTSD, BPD and schizophrenia and find features that are present exclusively in DID. Methods and Results The review included 17 scientific articles. DID-groups had more and more severe symptoms, especially concerning dissociation. Also, the ability to function in everyday life was better in DID-patients. Overall, they had more unusual perceptional experiences, positive and borderline symptoms than PTSD-groups, more amnesia, other psychiatric diagnoses and different kind of usage of defences than within BPD-patients, and more positive symptoms than schizophrenics, differing particularly in the quality of auditory hallucinations. On the other hand, BPD-groups had more borderline personality features whereas schizophrenics were more delusional than DID-patients. Discussion The review was not able to identify any factors that would account exclusively for DID, but the amount of dissociation and severity of symptoms were found as concurrent factors that help to differentiate DID from PTSD, BPD and schizophrenia. However, there are also many subtle differences between specific examined disorders and DID, which have to be taken into consideration. Useful methods in differential diagnosis are structured clinical interviews based on DSM-5, measures of dissociation and observations by significant others. Problems relating to the research of DID will be discussed.
  • Pöllä, Satu (2017)
    Body dysmorphic disorder (BDD) is a disorder that consists of a distressing and impairing preoccupation with a nonexistent or slight defect in appearance. Patients often seek surgical, dermatologic and other nonpsychiatric medical treatment for their perceived appearance flaws. Psychological and pharmacological interventions are suggested format for the treatment. The aim of this study is to determine the effectiveness of the treatments of body dysmorphic disorder. The main interest is in the effectiveness of psychotherapy and which therapeutic techniques or strategies are effective in the treatment of body dysmorphic disorder. Although research on treatment is still limited, findings support the effectiveness of psychotherapy suggesting that cognitive-behavioral therapy is effective in treating patients with body dysmorphic disorder. Effective therapy may consist of both cognitive and/or behavioral elements, but use of exposure and response prevention is reported in many studies. Findings also suggest that serotonin reuptake inhibitors may be useful in treating patients with body dysmorphic disorder but nonpsychiatric medical treatment usually does not improve BDD symptoms. Although treatments improved the appearance of the treated body part, it led not to improvement in BDD symptoms.
  • O'Shea, Mia (2019)
    Depression is the most prevalent psychiatric disorder amongst seniors in Finland, with about 5% experiencing major depression at any one time. As the population of Finland is slowly growing older, a large proportion of the nation are in late adulthood or retirement and more effort should be put towards the widespread issues which come with old age. Most cases of geriatric depression are treated with either psychosocial interventions or antidepressant treatments, neither of which guarantee definitive success in eliminating symptoms altogether. Antidepressants especially often come with unwanted side-effects, conflict with other medications and are expensive in long-term treatment. Listening to music could be administered as a standalone treatment or within music therapy as a cost-effective, non-invasive and non-pharmacological treatment for elderly depression. Music acts as a powerful stimulant by altering neural activation in many functional brain areas associated with audition, emotions, memory, and movement. Listening to music has been found to alleviate symptoms of depression by encouraging emotional expression, processing of feelings and by altering negative mental states. The purpose of this review was to explore previous research in order to conclusively draw together findings in the effects of music listening on late-life depression. Google Scholar and PubMed -databases were thoroughly enquired to find the latest meta-analyses, systematic reviews, randomized controlled trials and other information relevant to the subject. Altogether three of the most recent meta-analyses were included, as well as an additional three systematic reviews and three RCTs published outside of these. Drawing together findings from various sources, it is evident that music listening has complex beneficial effects and is an effective method in reducing depressive symptoms in older adults. Music listening can be implemented as a therapeutic tool in stand-alone treatment, as part of an intervention or within a music therapy framework.
  • Dunkel, Elias (2016)
    Children and adolescents have a high rate of participation in organized sports and physical activities. Participation in contact sports has been shown to be related to an elevated risk of suffering a concussion, which makes the management of concussions in child and adolescent athletes an important public health concern. Most of the research on concussion has been conducted on adults and the management protocols of concussions in both adult and youth athletes is based on this research. In this thesis I aim to provide an overview of the common symptoms and consequences of sports-related concussions, the effect of recurring concussions, and the special concerns relating to sports-related concussions in child and adolescent athletes. Research suggests that despite significant overlap, clinical and neuropsychological symptoms of a concussion may resolve at a different rate. In addition, neurophysiological functions appear to be altered for a far longer period than either clinical or neuropsychological symptoms. This is a cause for concern, as return-to-play (RTP) policy of concussed athletes is often based on clinical symptoms alone. A conservative RTP policy should be considered especially in concussed child and adolescent athletes, as they seem to recover slower than adults. Supervision is essential in concussion management, as youth athletes are often unaware of previously sustained concussions, premature RTP may expose the athlete to an elevated risk of suffering a second injury, and recurring concussions have been shown to have accumulating effects on neurocognitive functions.
  • Närvänen, Eija (2019)
    Objective. Transdiagnostic models of psychopathology assume that the commonalities across disorders may outweigh their differences. While these models acknowledge that disorder-specific symptoms and features undoubtedly exist, the same underlying factors are perceived to cause and maintain various disorders. In recent years, this approach has received growing attention and several new forms of therapy have been developed based on it. These may be well-suited for the treatment of mixed-diagnosis groups or individuals with comorbid disorders, and as such, they hold the promise of being very cost-effective. One of the most established transdiagnostic treatments is the Unified Protocol (UP), designed to help patients suffering from depression and the full range of anxiety disorders. The purpose of the present study is to review the evidence regarding the efficacy and effectiveness of the UP for the transdiagnostic treatment of adult anxiety and depression. Methods. For this review, systematic literature searches were performed using the PsychInfo and PubMed online databases in October 2018. The search term used was “Unified Protocol”. The search yielded 114 results in PsychInfo and 138 in PubMed. Ten of these matched the following study selection criteria and were included in the current review: a) the study measured either the efficacy or effectiveness of the cognitive-behavioral UP therapy developed by Barlow (2011), b) treatment was delivered face-to-face in either individual or group setting, c) treatment followed the UP therapist guide without major modifications, d) participants suffered from an anxiety disorder or depression, e) participants were over 18 years of age, d) the study was published in 2015 or later, and f) the study was published in English in a peer-reviewed journal. Results and conclusions. The UP appeared both efficacious and efficient in reducing the severity of adult anxiety and depression as well as the number of comorbid diagnoses; however, there were some conflicting findings regarding recovery rates and effect sizes. The results achieved were comparable to those achieved using diagnosis-specific cognitive-behavioral therapy. The UP treatment had a positive impact on the patients’ functioning and quality of life and the amount of positive and negative affect they experienced. Treatment retention was generally high, particularly when treatment was delivered individually, and the UP received high ratings from those who participated in the studies. All in all, the current empiric evidence regarding the UP appears fairly promising. However, these results must be interpreted with caution, as the research concerning the UP is still in its infancy and a large part of it has been conducted by researchers affiliated with the treatment.
  • Viljakainen, Pia (2018)
    First impressions are quickly formed observations of a new acquaintance. The basis of these observations is to find out what are the intentions of the other person. Therefore, the question behind is to find out whether they are a friend or an enemy. This happens automatically and as studies have found within mere fraction of seconds. It has been found that longer observations of others lead to more precise conclusions and after five seconds people are able to judge each other’s extroversion above chance level. Furthermore, studies point out that first impressions are vulnerable to error as for example positive features like physical attractiveness and success are linked together. In addition, studies show that features signaling threat are seen faster than positive features. According to evolutionary psychology this behavior is valuable for staying alive. Studies also show that to some extent people can impact on their first impression and in photographs people have been successfully able to act extraversion and openness. The purpose of this overview is to consider first impressions and the questions of how they are formed and if they are truthful. In addition, this overview analyzes whether people are aware of the first impressions made of them and whether they can have an impact on them.
  • Naskali, Anni (2017)
    Studies have shown that childhood physical abuse is associated with later adverse psychological development and mental health. Additionally, people who have experienced physical abuse have a higher risk for later violence. However, most people who have experienced childhood abuse do not become violent offenders which implies that the two factors are not directly linked. Mediating factors might account for the relationship. Alcohol related problems and antisocial personality disorder are psychiatric disorders which have been associated with childhood physical abuse and intimate partner violence. These disorders are examined here as possible mediators in the relationship between childhood physical abuse and later intimate partner violence. There are mixed results concerning the mediating role of alcohol related problems. These results indicate that alcohol related problems do not mediate the relationship between childhood abuse and violence. Alcohol related problems might work as a mediator for individuals with other risk factors. Studies have found that antisocial personality disorder has a mediating role in the relationship between childhood physical abuse and intimate partner violence. Abuse in childhood combined with a genetic risk for antisocial personality may lead to the development of the disorder which increases the risk for violence. In order to develop effective interventions, it is important to understand the adverse effects of childhood abuse. Moreover, mediating factors should be considered when designing interventions targeting intimate partner violence.
  • Mikkonen, Kasperi (2016)
    Borderline personality disorder is a difficult disease which lowers the patients general functioning drastically. It is characterized by increased mortality rate and high treatment costs. Symptoms of borderline personality disorder are very complex and its aetiology is far from simple. The goals of this literature review were to review the genetic background of the disorder and possible overlapping genetic factors between borderline personality disorder and other psychiatric disorders. Large-scale twin studies show that the heritability of borderline personality disorder varies between 0,35-0,67. It can be said that the incidence of borderline personality disorder is strongly influenced by genetic factors. However, genome-wide association studies are scarce so the specific genetic mechanisms are largely unknown. Studies show that many other psychiatric disorders have common factors and genetic overlap with borderline personality disorder. These disorders include for example attention deficit hyperactivity disorder, depression and substance use disorders. This review suggests that better understanding of the genetic factors of borderline personality disorder could improve diagnostics and treatment methods.
  • Huotari, Pinja (2020)
    Introduction: The purpose of this review is to point out the results of genetic studies on borderline personality disorder and to discuss the possible genetic influence in the development of the disorder in relation to other influencing etiological factors. This review evaluates if research results support the heritability of borderline personality disorder. At the early stages of the disorders’ etiological studies only psychosocial factors were examined, thus the genetic point of view in the development of borderline symptoms was ignored. The genetic perspective has received more attention lately, however the amount of genetic studies on the subject is still rather limited. Methods: A literature search was conducted using OvidMedline database using search terms borderline personality disorder, BPD, impulsivity, heritability, genetics, development, family studies, adoption studies and twin studies. Results and Conclusions: The results of genetic studies on borderline personality disorder support its heritability. Family studies suggest a noticeable familial aggregation effect, and the risk for borderline personality disorder was greater for immediate relatives of individuals who have been diagnosed with borderline personality. Based on findings from twin studies, the heritability varied between 42-69 percent. Genetic research has not yet identified genetic variants specific to borderline personality disorder, but there was some evidence of a common genetic liability across multiple mental health disorders. Borderline personality disorder is one of the most challenging mental health disorders, and regardless its low prevalence it often leads to hospitalization or outpatient care. With an early identification and focused treatment, it could be possible to lessen individual’s suffering, increase ability to function and reduce the financial burden it causes to society. Since research results support borderline personality disorder’s heritability, raised awareness about the genetic liability amongst health care professionals is a promising start in identifying high-risk groups and planning the treatment.
  • Grandell, Leena (2018)
    Objectives. Psychotherapy research has traditionally concentrated on the positive outcome of therapy whereas negative outcome has not been an object of interest. A comparison to psychopharmacological treatment, for which reporting of side-effects is mandatory, reveals a difference. The area of psychotherapy outcome has lacked consensus on theoretical, methodological and practical issues. This bachelor thesis is a literature review on the subject. The review is limited to cover research projects dealing with adult individual psychotherapy for mood and anxiety disorders concentrating on cognitive and psychodynamic therapy orientations. Method. The Bachelor thesis consisted of a literature review covering international scientific papers on negative outcome of psychotherapy concentrating on following research questions: operationalisation of psychotherapy outcome, measures for monitoring outcome, categorisation of psychotherapy outcome and methods for distinction between the categories. Additionally the work covered a review on quantitative results. Results and conclusions. No consensus on measuring psychotherapy outcome and the categorisation of outcome was evident. A typical approach was using the categories “recovered”, “improved”, “non-response” and “deteriorated”. Two alternative means of operationalising the psychotherapy outcome could be found. Measures for estimating symptomatic level, interpsychological functioning and social functioning were combined with the reliable change index (RCI) to assess observed changes. Another alternative formed measures to assess directly adverse effects of psychotherapy. Quantitative estimates of negative outcome were consistent: prevalence of deteriorated patients varied between 1 – 7% and share of non-responders was 39-67%
  • Lintula, Sakari Johannes (2018)
    The recognition of faces is a widely researched process. Typically, this process is thought of as separate from other object recognition: a specific mechanism. Today’s neural models of face processing also presume the previous assumption. A competing hypothesis for this specificity hypothesis is the expertise hypothesis, which claims that the recognition of faces is unique due to the vast amount of experience we have with faces. The conversation regarding the expertise hypothesis has surrounded largely the function of the FFA. In this review, evidence for the FFA’s role as a general, not face specific, object recognition module is presented. As an explanation for the current evidence for the role of the FFA a holisticity hypothesis is proposed: FFA is a module of holistic visual processing. Finally, critical notations for following research are discussed.
  • Pajunen, Sara (2016)
    Physical activity has a positive impact not only on physical and mental health but also on cognitive functions. It seems that physical activity improves performance in a variety of cognitive tests and slows down the natural cognitive decline associated with aging. During adolescence the plasticity of the brain is greater and parts of the brain that are essential for cognitive functions develop significantly. At the same time there is some evidence that globally increasing physical inactivity and obesity might influence negatively on health of the brain and further on cognitive functions. From this point of view physical activity may have an underestimated role supporting cognitive development in youth. Physical activity has a positive effect on performance in a variety of cognitive tests in adolescence. Physically active adolescents outperform physically inactive controls in verbal and numerical abilities, different reasoning ability tests and especially in tests that measure executive functions and attention. Physical exercise has a positive effect also on emotional well-being, behaviour and academic achievement. Based on the articles of this thesis regular organized physical exercise that is vigorous and includes a cognitive component has the strongest impact on cognitive performance. In some studies the association between physical activity and cognitive and academic performance was stronger in girls than boys. This finding could be explained by the fact that physical exercise decreases symptoms of anxiety and depression and that girls have more of these symptoms than boys. The underlying mechanisms of the association include learning and developmental mechanisms and physiological mechanisms that include functional and structural features of the brain. Physical exercise increases cerebral blood flow and oxygen intake in the brain and upregulates multiple neurotrophic factors that are essential for new neurons. Regular physical exercise possibly leads to more efficient neuronal networks and permanent cortical changes in adolescent’s brain. Scarce literature and various study designs might explain some of the inconsistency in the results. In the future more research is needed about what kind of physical exercise by type, intensity and duration is the most effective on cognitive development in adolescence. Increasing amount of literature supports the idea that physical activity is a lifestyle factor that has a holistic impact on health and well-being throughout the lifespan.
  • Danesi, Claudia (2020)
    Maternal prenatal depression is associated with increased prevalence of mental disorders in the offspring, but the underlying mechanisms are yet to be discovered. It has been proposed that prenatal stress could cause changes in the hypothalamus-pituitary-adrenal-axis (HPA) function and glucocorticoid secretion of the fetus. Animal models have shown that an adverse early life environment is associated with glucocorticoid receptor gene (GR) methylation and increased stress reactivity in adulthood through decreased negative feedback. Decreased negative feedback is thought to increase the concentration of glucocorticoids, which influence amongst other things central nervous system development. This bachelor thesis aims to clarify the role of glucocorticoids in fetal programming. To outline the subject the thesis seeks to answer two questions; first, whether maternal prenatal depression is linked to GR-gene methylation and second, if maternal prenatal synthetic glucocorticoid treatment is associated with increased psychiatric symptoms in the offspring. Based on the literature review, maternal prenatal depression and GR-gene methylation are not strongly associated. This interpretation could partly be due to small sample sizes and variability of depressive symptoms. Prenatal synthetic glucocorticoids and HPA-axis dysfunction seem to be associated with increased prevalence of mental health disorders. This highlights the importance of discretion in glucocorticoid treatments associated with pre-term birth. Glucocorticoid treatments can affect the epigenome and it is likely that future research should focus more on the epigenetic changes of GR responsive genes. Glucocorticoids are likely involved in mediating the effects of adverse prenatal environment on the fetus. More research combining data from longitudinal studies and experimental laboratory research is needed to discover the possible causal mechanisms.