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Browsing by Author "Hirvonen, Elina"

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  • Hirvonen, Elina (University of HelsinkiHelsingin yliopistoHelsingfors universitet, 2009)
    Tutkimamme bakteeri, Faecalibacterium prausnitzii kuuluu terveen aikuisen ihmisen normaaliin suoliston mikrobistoon yhtenä sen runsaslukuisimmista edustajista. Crohnin taudissa, johon liittyy suoliston mikrobiston epätasapainoa (dysbioosi), Clostridium leptum -ryhmään kuuluvan F. prausnitzii -bakteerin määrän on havaittu olevan normaalia alhaisempi. Kahdessa eri tutkimuksessa tavoitteenamme oli selvittää, miten F. prausnitzii -bakteerin tai sen aineenvaihduntatuotteiden tuominen ennakoivasti eläimeen vaikuttaa tulehduksen kulkuun ja vakavuuteen, sekä toimiiko hoito myös suolesta riippumatonta reittiä (intraperitoneaali-injektio) käyttäen. Mallintamiseen käytettiin trinitrobentseeni sulfonihappo- (TNBS) suolistotulehdusta hiirillä. Sekä Faecalibacterium prausnitzii -bakteerin että sen aineenvaihduntatuotteita sisältävän kasvuliuoksen (supernatantti) osoitettiin hillitsevät tulehdusta TNBS-tulehdusmallissa hiirillä. Käyttämiemme tulehduksen arvosteluperusteiden mukaan molemmat hoidot näyttivät edesauttavan normaalin terveydentilan saavuttamista. Ne hillitsivät esitulehduksellisten sytokiinien tuotantoa sekä vaikuttivat suotuisasti suolenontelon mikrobilajiston tasapainoon koehiirten suolistotulehduksessa. Supernatantti myös lisäsi tulehdusta lievittävän interleukiinin, IL-10 tuotantoa Hoidot tehosivat myös sovelletussa TNBS-mallissa intraperitoneaaliruiskeena: hoidettujen hiirten kuolleisuus väheni kontrolliryhmiin nähden merkittävästi. Näin ollen bakteerin tai siitä valmistetun supernatantin ei tarvitse olla suolenontelossa vaikuttaakseen tulehdusta hillitsevästi.
  • Hirvonen, Elina (2016)
    The main aim of this thesis was to study the ecosystem services provided by large-scale industrial eucalypt plantations of UPM in Paysandú region, Uruguay. In the landscape, natural pastures and forests are combined with rows of planted trees. The second aim was to study how various stakeholder groups use ecosystem services from the plantation landscape, and to what extent the rights and expectations related to their use vary among these groups. The third aim was to study the best ways to combine the production of ecosystem services with large-scale industrial tree plantations in the study area. The data used in this study consisted of 55 semi-structured interviews, which were recorded in Uruguay during summer of 2015. Among the persons interviewed, 15 people were classified as key-informants with a broad view on plantation industry in the study area. They were from educational institutions, companies, ministries and from non-governmental organizations. Based on results of the key-informants interviews, a total of 40 persons were selected for stakeholder interviews. They represented four groups; 1) cattle ranchers, 2) honey producers, 3) tree growers and 4) general public from the surrounding communities. With stakeholder interviews, the aim was to collect quantitative data with structured questionnaires. The key-informants and stakeholders were asked about the same issues, but the key-informant interviews had open questions for collecting both qualitative and quantitative data. The results of this study show that industrial tree plantation landscapes provide a plenitude of ecosystem services. However, the perceived changes in the landscape during the past ten years were in some cases more negative than positive. According to the key-informants, the most important ecosystem services provided included industrial wood, animal shelter, fodder and foods. This indicates that local livelihoods can be combined with industrial plantations and the stakeholders benefit from them in many ways. The cattle ranchers obtained mainly animal shelter and fodder. For them, also the regulation of natural hazards was important. The honey producers valued foods, pollination and biodiversity services. The tree growers valued industrial wood and, similarly as the cattle ranchers, animal shelter and fodder. For the general community, educational information was the most important service. Food, honey and mushrooms, and fuel wood were also highly valued ecosystem services. Industrial tree plantations create a wealth of ecosystem services, often with low or no cost. UPM Uruguay considers local stakeholders and their livelihoods in many ways. According to the company, the best ways to integrate industrial tree plantations and ecosystem services are already used in many parts, although there was no data disclosed about all of them. However, it seems that UPM is well aware of the local conditions. In the future, there is a need to study the monetary value and benefit sharing of ecosystem services e.g. through payments of ecosystem services schemes.