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Browsing by Author "Koskinen, Seppo"

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  • A nationally representative follow-up study on atrial fibrillation : morbidity and mortality 
    Lemma, Jasmiini; Nieminen, Tuomo; Kyhälä-Valtonen, Hanna; Nieminen, Markku; Salomaa, Veikko; Anttila, Ismo; Kerola, Anne; Rissanen, Harri; Jula, Antti; Koskinen, Seppo (2017)
    Aims: Atrial fibrillation (AF) is the most common long-standing arrhythmia in the adult population. This study aimed to assess which factors increase the likelihood of developing AF, and whether AF is associated with worsened survival in the new millennium. Methods: 6299 participants from a nationally representative Finnish health cohort were followed from 2000 to 2014. The mortality and risk of developing AF were analyzed using Cox regression and logistic regression models. Results: The overall prevalence of AF in baseline ECG was 1.5%. During the 13 year follow- up, 16.9% of those without baseline AF and as many as 85% of those with AF at baseline died. AF increased the risk of dying 5-fold in unadjusted and 1.86-fold in adjusted analysis. In addition, age, gender, hypertension, heart failure, chronic obstructive pulmonary disease (COPD), diabetes and smoking were associated with increased mortality in the Cox regression model. During the first 10 years of follow-up, male gender, age, BMI and alcohol consumption were associated with developing AF. Conclusion: AF is clearly linked with mortality even after the emergence of modern anticoagulation therapy. BMI and alcohol consumption were the only modifiable health factors associated with the development of AF.
  • Incidence trends and risk factors of lung cancer in never smokers : pooled analyses of seven cohorts 
    Rissanen, Emilia; Heikkinen, Sanna; Seppä, Karri; Ryynänen, Heidi; Eriksson, Johan G; Härkänen, Tommi; Jousilahti, Pekka; Knekt, Paul; Koskinen, Seppo; Männistö, Satu; Rahkonen, Ossi; Rissanen, Harri; Malila, Nea; Laaksonen, Maarit A; Pitkäniemi, Janne (2021)
    The trends in incidence of lung cancer in never smokers are unclear as well as the significance of risk factors. We studied time trends in the incidence and risk factors of lung cancer in never smokers in Finland in a large, pooled cohort. We pooled data from seven Finnish health cohorts from the period between 1972 and 2015 with 106 193 never smokers. The harmonized risk factors included education, alcohol consumption, physical activity, height, and BMI. We retrieved incident lung cancers from the nation-wide Finnish Cancer Registry. We estimated average annual percent change (AAPC) and the effects of risk factors on cause-specific hazard ratios (HRs) of lung cancer using Poisson regression. We detected 47 lung cancers in never smoking men (n=31 859) and 155 in never smoking women (n=74 334). The AAPC of lung cancer incidence was -3.30% (95% confidence interval (CI): -5.68% - -0.88%, p=0.009) in never smoking men and 0.00% (95% CI: -1.57%-1.60%, p=0.996) in never smoking women. Of the five studied risk factors only greater height in women had a statistically significant increased risk of lung cancer (multivariate HR=1.84, 95%CI: 1.08-3.12). It is plausible that tobacco control measures focused on working places have reduced passive smoking among men more than among women, which could explain the declining trend in lung cancer incidence in never smoker men but not in never smoker women. As tobacco control measures have not been targeted to domestic environments, it is likely that women’s exposure to passive smoking has continued longer.

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