Browsing by Subject "Pediatric-onset disease"

In this retrospective study 27 patients with PSC and concurrent IBD were depicted from hospital files. 81 controls were also chosen. Information on colonoscopy findings, histology, surgery, medication, overall patient well-being and growth was collected from patients files. The aim of this study was to observe how IBD develops in the presence of PSC, AIH and PSC-AIH. In this study we found that AILD-IBD patients seemed to have a milder disease course regarding IBD. Colonoscopy findings suggested a slightly more aggressive disease course in controls. AILD-IBD patients had less histologic inflammation, no adenocarcinoma was discovered and underwent less bowel surgery than controls. However, AILD-IBD patients received more J-pouches but suffered less from pouchitis and recurring pouchitis. TNF-alfa inhibitor and AZA/MTX use was higher in the control group. Growth delay occurred in both groups, but was more common in CD patients in the control group.