Browsing by Subject "Käyttäytymiskoe"

Changes in environmental and psychological factors have greatly influenced human eating behavior, leading to increasing rates of overeating. In the long-term continuous overeating causes the body to accumulate an excess amount of body fat tissue, which is a leading factor in the development of obesity and obesity related diseases that reduce the quality of life. Despite the available treatment options, the prevalence of obesity has been increasing worldwide. In avoiding obesity and obesity-related diseases, it is crucial to understand the outside factors which lead to obesity and the mechanisms which regulate body energy balance. The brain's serotonin system seems to play a significant role in regulating both energy balance and the tendency that promotes an overeating type of eating behavior. The properties of psychedelics to affect human's emotional state and thus modulate behavioral patterns through the brain's serotonin system has aroused interest in psychedelics for their possibilities in treating eating behaviors that promote overeating which results in obesity. This study aimed to examine the dose-dependent effect of three different psychedelics on eating behavior in mice and evaluate their potential drug therapy properties in overeating indulged obesity. In total, 16 female mice were trained to perform in an operant setting used in behavioral experiments measuring appetite and motivation for food reinforcers. The psychedelic-derived changes were observed in mice's eating behaviors by reward deliveries received during the trials. The examined psychedelics (lysergic acid diethylamide (LSD), psilocybin (PSI), and 25CN-NBOH) showed no statistically significant changes in the mice's eating behavior in terms of appetite and motivation. However, while statistically non-significant, some changes in hunger and motivation were observed in the mice, for example, in days followed by the dosage of the psychedelics. These results indicate no effect on appetite and food motivation by the studied psychedelics.