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A comparison of methods for haplotype inference

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Title: A comparison of methods for haplotype inference
Author(s): Hyvönen, Elvira
Contributor: University of Helsinki, Faculty of Science, Department of Mathematics and Statistics
Language: English
Acceptance year: 2013
This study presents some of the available methods for haplotype reconstruction and evaluates the accuracy and efficiency of three different software programs that utilize these methods. The analysis is performed on the QTLMAS XII common dataset, which is publicly available. The program LinkPHASE 5+, rule-based software, considers pedigree information (deduction and linkage) only. HiddenPHASE is a likelihood-based software, which takes into account molecular information (linkage disequilibrium). The DualPHASE software combines both of the above mentioned methods. We will see how usage of different available sources of information as well as the shape of the data affects the haplotype inference.

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