Browsing by Author "Kambur, Oleg"

Acute coronary syndrome incidence and case fatality have declined in the past decades, but some studies have suggested a potential stagnation in this decline. Therefore, we examined how the burden of the acute coronary syndrome has evolved among persons aged 35-74 in Finland from 1996 to 2021. We gathered data linking Finnish country-wide Hospital Discharge- and Causes of Death- Registers together with the help of unique personal identification number. With this our data contains all the first non-fatal and fatal acute coronary syndrome events happened in Finland during our study period. Altogether, the data consisted of 186 489 non-fatal and 72 907 fatal acute coronary syndrome events. We analysed incidence, mortality, and 28-day case fatality, and their trends and trend changes using negative binomial, Poisson, segmented, and logistic regression adjusting for age and sex. The acute coronary syndrome incidence declined in all age groups of men and in older women, age groups 55- 64 and 65-74. However, the incidence decline slowed down over the last decade. In women’s age groups of 35-44 and 45-54, the incidence was unchanged during the study period. The acute coronary syndrome mortality decline was fast in men and women and the rate of decline was quite similar in all age groups. Also, case fatality declined in all age groups of men and women. The decline in case fatality was most significant in the youngest age group which consisted of people aged 35-¬54 years. Our study shows that the acute coronary syndrome mortality and case fatality has declined in all groups, but the decline in the acute coronary syndrome incidence slowed down and even halted in women in the 2010s. In women aged 35-54, the incidence was unchanged between 1996 and 2021. These results emphasize the need for intensified cardiovascular prevention, particularly in women.