Browsing by Author "Salomaa, Veikko"
Now showing items 1-4 of 4
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Lemma, Jasmiini; Nieminen, Tuomo; Kyhälä-Valtonen, Hanna; Nieminen, Markku; Salomaa, Veikko; Anttila, Ismo; Kerola, Anne; Rissanen, Harri; Jula, Antti; Koskinen, Seppo (2017)Aims: Atrial fibrillation (AF) is the most common long-standing arrhythmia in the adult population. This study aimed to assess which factors increase the likelihood of developing AF, and whether AF is associated with worsened survival in the new millennium. Methods: 6299 participants from a nationally representative Finnish health cohort were followed from 2000 to 2014. The mortality and risk of developing AF were analyzed using Cox regression and logistic regression models. Results: The overall prevalence of AF in baseline ECG was 1.5%. During the 13 year follow- up, 16.9% of those without baseline AF and as many as 85% of those with AF at baseline died. AF increased the risk of dying 5-fold in unadjusted and 1.86-fold in adjusted analysis. In addition, age, gender, hypertension, heart failure, chronic obstructive pulmonary disease (COPD), diabetes and smoking were associated with increased mortality in the Cox regression model. During the first 10 years of follow-up, male gender, age, BMI and alcohol consumption were associated with developing AF. Conclusion: AF is clearly linked with mortality even after the emergence of modern anticoagulation therapy. BMI and alcohol consumption were the only modifiable health factors associated with the development of AF.
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Hirvonen, Katariina; Korhonen, Tellervo; Salomaa, Veikko; Männistö, Satu; Kaprio, Jaakko (2017)DBH-geeni koodaa dopamiinia hajottavaa entsyymiä, joka on liitetty palkkiojärjestelmään vaikuttamisen kautta erilaisiin riippuvuuksiin. DBH:n variaatioiden on todistettu liittyvän tupakointikäytänteisiin ja –tapoihin monessa tutkimuksessa. Viimeisimpänä rs3025343 liitettiin tupakoinnin lopettamiseen suuressa GWAS meta-analyysissa. Tutkimuksemme tavoitteena olikin replikoida kyseinen löydös suuressa väestötutkimusnäytteessämme. Lisäksi halusimme tutkia, vaikuttaisiko rs3025343 jonkin muun ympäristötekijän kautta vai itsenäisesti tupakoinnin lopettamiseen. Tutkimusnäytteemme on peräisin suomalaisesta väestönäytteestä, FINRISK-tutkimuksesta. Siihen lukeutuu 26,582 genotyypattua henkilöä tupakointistatuksineen. Analyysit rajasimme 11,926 yksilöön, jotka olivat joko nykyisiä tupakoitsijoita (n=6,578) tai vähintään 6kk sitten tupakoinnin lopettaneita (n=5,348). Henkilöistä oli saatavilla myös kattavasti muita tietoja mukaan lukien sosioekonominen status, terveyteen liittyviä tapoja ja terveydentila, joita käytimme analyyseissä hyväksi. Yhteys rs3025343 ja tupakoinnin lopettamisen välillä (OR=1.12, p=0.094, 95%CI=0.98-1.30) osoittautui tutkimuksessamme identtiseksi GWAS-tutkimuksen kanssa (OR=1.12, 95%CI=1.08-1.18). Mikään testatuista fenotyypeistämme ei vaikuttanut tuohon yhteyteen merkitsevästi. Siviilisääty, koulutustaso, masennus, alkoholin käyttö, itseraportoitu terveys sekä COPD assosioituivat fenotyyppitekijöistä tupakoinnin lopettamiseen, mutta mikään edellämainituista assosiaatioista ei riippunut tutkimastamme genotyypistä. Vaikka tutkimustuloksemme ei ole tilastollisesti merkitsevä, efektikoko viittaa vahvasti siihen, että tutkimallamme polymorfismilla on jonkinasteinen yhteys tupakoinnin lopettamiseen. Merkitevyyden esiinsaamiseksi riittävällä voimalla (80%) otoskoon tulisi olla niinkin suuri kuin 36,092 tapausta ja 29,343 kontrollia, koska harvinaisemman alleelin kantajia on suhteellisen vähän (7,1%). DBH-geenin variaatiot ovat osoittautuneet monessa tutkimuksessa olevan yhteydessä nikotiiniriippuvuuteen tai tupakoinnin lopettamiseen. Jos näitä yhteyksiä saadaan tutkittua lisää, on mahdollista että tietoja voitaisiin käyttää hyväksi tulevaisuudessa esim. yksilöllisesti räätälöidyssä tupakoinnin lopettamisen hoidossa.
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Kallström, Atte; Holopainen, Ida; Kambur, Oleg; Perola, Markus; Salomaa, Veikko; Havulinna, Aki; Ramste, Markus; Sinisalo, Juha (2024)Acute coronary syndrome incidence and case fatality have declined in the past decades, but some studies have suggested a potential stagnation in this decline. Therefore, we examined how the burden of the acute coronary syndrome has evolved among persons aged 35-74 in Finland from 1996 to 2021. We gathered data linking Finnish country-wide Hospital Discharge- and Causes of Death- Registers together with the help of unique personal identification number. With this our data contains all the first non-fatal and fatal acute coronary syndrome events happened in Finland during our study period. Altogether, the data consisted of 186 489 non-fatal and 72 907 fatal acute coronary syndrome events. We analysed incidence, mortality, and 28-day case fatality, and their trends and trend changes using negative binomial, Poisson, segmented, and logistic regression adjusting for age and sex. The acute coronary syndrome incidence declined in all age groups of men and in older women, age groups 55- 64 and 65-74. However, the incidence decline slowed down over the last decade. In women’s age groups of 35-44 and 45-54, the incidence was unchanged during the study period. The acute coronary syndrome mortality decline was fast in men and women and the rate of decline was quite similar in all age groups. Also, case fatality declined in all age groups of men and women. The decline in case fatality was most significant in the youngest age group which consisted of people aged 35-¬54 years. Our study shows that the acute coronary syndrome mortality and case fatality has declined in all groups, but the decline in the acute coronary syndrome incidence slowed down and even halted in women in the 2010s. In women aged 35-54, the incidence was unchanged between 1996 and 2021. These results emphasize the need for intensified cardiovascular prevention, particularly in women.
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Havulinna, Aki; Salomaa, Veikko; Tervahartiala, Taina; Aarabi, Ghazal; Vihervaara, Terhi; Sorsa, Timo; Pussinen, Pirkko; Salminen, Aino; Ranta, Julia (2022)Background: Matrix-degrading proteinases and their regulators, such as matrix metalloproteinase 8 (MMP-8) and tissue inhibitor of matrix metalloproteinase 1 (TIMP-1), may contribute to various pathological events. Elevated serum MMP-8 concentrations have been associated with e.g. cardiovascular diseases and poorer prognosis of certain cancers. However, there is little knowledge on physiological concentrations of these molecules in serum, or the effect of demographic or lifestyle factors on their levels. Design and methods: We investigated the effect of various demographic characteristics and behavioral habits, such as aging, sex, smoking, and BMI, on serum concentrations of MMP-8 and TIMP-1. We used the FINRISK97 cohort (n = 8446), which has comprehensive information on demographic and lifestyle factors, clinical data, laboratory measurements, and register data available. Further, we investigated the concentrations of MMP-8, TIMP-1, and the MMP-8/TIMP-1 ratio in different age groups of healthy and diseased participants. Linear regression was used to evaluate the association between MMP-8 and TIMP-1 and selected diseases and background variables. Results: MMP-8 levels decreased with increasing age in the whole population and for women, while TIMP-1 concentration increased slightly with age for the whole population and both genders separately (p for linear trend <0.001). The concentrations of MMP-8 were lower and TIMP-1 higher in men compared to women (p<0.001). Additionally, significant positive association was found for MMP-8 and smoking, CRP, and inverse association with obesity and fasting time. For TIMP-1, significant positive association was found with smoking, CRP and obesity, and an inverse association with prevalent diabetes. Conclusion: Serum MMP-8 levels decrease significantly with age, potentially reflecting the attenuated immune response in the elderly. In addition, sex, smoking, and obesity are associated with serum MMP-8 and TIMP-1 concentrations. These factors should be considered in epidemiological studies on serum MMP-8 and TIMP-1.
Now showing items 1-4 of 4