Browsing by Author "Wasenius, Niko"

Aims The aim of this study was to evaluate whether maternal type 1 diabetes influences skin autofluorescence (SAF), used as a marker of accumulated advanced glycation end products (AGEs), in young adult offspring. Methods This cross-sectional case-control study included 78 offspring of women with type 1 diabetes (cases) and 85 control participants (controls). Cases were born between 1st January 1996 and 31st December 2000, at the Department of Obstetrics and Gynecology, Helsinki University Hospital, and controls were born during the same period in the Hospital District of Helsinki and Uusimaa, Finland. All study participants, aged 18 to 23 years, were invited to participate in a clinical assessment including laboratory tests and questionnaires. SAF was assessed from all participants using the AGE reader. Results The mean SAF value did not differ between the cases (1.61 [0.37]) arbitrary units [AU]) and the controls (1.64 [0.41] AU) (p=0.69). After adjusting for HbA1c, body fat percentage, smoking, and season the mean SAF value did not differ between the cases and the controls (p=0.49) but differed between men and women (p=0.008), without any interaction observed (p=0.78). Conclusions No differences in SAF values were observed between the young adult offspring of women with type 1 diabetes and offspring born to mothers without diabetes. Surprisingly, young adult women showed higher SAF values than men in both case and control groups.