Browsing by Author "Jortikka, Anna"

Cyanobacteria are known producers of bioactive secondary metabolites. The compounds isolated here, heinamide variants A-G, are split into two groups based on their either 11 or 12-residue structure. These variants work in synergy between size groups to produce increased inhibitory effects toward the fungus Aspergillus flavus. However, like-sized variants do not work in synergy the way the 11-residue and 12- residue variants work together. A proposed gene cluster and biosynthetic pathway for the related compound scytocyclamide is characterized here and can be used as a hypothetical model for heinamide production. Though there are a variety of bioactive effects exhibited by related compounds, in this study heinamide was only found to have bioactive properties toward Aspergillus flavus.