Browsing by Subject "25-hydroksivitamiini D"

Vitamin D is either obtained through synthesis in the skin due to UVB-light (290-315 nm) or from the diet. The hydroxylased metabolite 25-hydroxyvitamin D (25(OH)D) is the metabolite to measure when vitamin D status wants to be determined. The active form of vitamin D is 1,25- dihydroxyvitamin D (1,25(OH)?D) which interacts with a large set of tissue cells (especially bone) through its nuclear receptor the vitamin D receptor (VDR). Vitamin D deficiency can lead to rickets in children and osteoporosis or osteomalacia in adults. Type 1 Diabetes (T1D) is an autoimmune disease which is caused by the destruction of the pancreatic ?-cells. The disease has genetic and environmental features but the whole mechanism of disease development is still unknown. The prevalence of T1D is constantly growing in the whole world. Therefore it is important to study possible environmental factors that can eventually serve as pathogenesis modifiers. Vitamin D and T1D have been associated among others because there is a seasonal and geographical variation in T1D incidence, more cases have been identified in the North and during winter. The aim of this study was to investigate if the serum 25(OH)D status during first trimester of pregnancy is associated with T1D development in the offspring. The subjects where mothers of T1D children (N=310) and the controls were mothers of healthy children (N=310). Serum samples were obtained from the Finnish Maternity Cohort (FMC) and analyzed for S-25(OH)D. S- 25(OH)D measurement was performed with an indirect enzyme immunoassay (EIA). No significant (p>0.05) difference was seen between S-25(OH)D mean concentrations in cases and controls. The mean concentration of cases was 43.3 ± 15.9 nmol/l and 43.0 ± 15.5 nmol/l (mean ± standard deviation (SD)) of controls. Insufficient and deficient S- 25(OH)D status was seen in 72% of the whole study population. As a result of this study it has been shown that the S-25(OH)D status during first trimester of pregnancy is not associated with T1D development in the offspring. Samples from later stages of pregnancy could be analyzed to determine if the overall status during pregnancy has an effect on T1D development in the offspring. Considering the possible health outcomes of vitamin D insufficiency, recommended vitamin D supplementation should be raised to improve maternal and fetal health.