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Browsing by Author "Barakhtii, Diana"

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  • Barakhtii, Diana (2023)
    This thesis presents the utilisation of nuclear magnetic resonance (NMR) spectroscopy for mechanistic and kinetic studies of the PFAA-Staudinger ligation through its perspective for further application for metabolic glycoengineering, hence nuclear imaging purposes. The literature review focuses on the bioorthogonal reactions, their comparison, known implementations and perspectives in nuclear imaging, specifically in metabolic glycoengineering. In an experimental part set of compounds was studied in different conditions with the same reagent in order to characterise triarylphosphines reactivity in the PFAA-Staudinger reaction. For analysis purposes, 1H and 31P NMR spectra of reagents, products and reaction mixtures were acquired and analysed.