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Browsing by Subject "BNCT"

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  • Nincă, Ilona Ştefana (2020)
    Cadmium Telluride (CdTe) has a high quantum efficiency and a bandgap of 1.44 eV. As a consequence, it is being used to efficiently detect gamma rays. The aim of this thesis is to explore the properties of the CdTe pixelated detector and the procedures conducted in order to fine-tune the electronic readout system. A fully functional CdTe detector would be useful in medical imaging techniques such as Boron Neutron Capture Therapy (BNCT). BNCT requires a detector with a good energy resolution, a good timing resolution and a good stopping power. Although the CdTe crystal is a promising material, its growing process is difficult due to the fact that different types of defects appear inside the crystal. The quality assurance process has to be thorough in order for suitable crystals to be found. An aluminum oxide layer (Al2O3) was passivated onto the surface of the crystal. The contacts for both sides were created using Titanium Tungsten (TiW) and gold (Au) sputtering deposition, followed by an electroless nickel growth. I tested the CdTe pixelated detector with different radioactive sources such as Am-241, Ba-133, Co-57, Cs-137 and X-ray quality series in order to study the sensitivity of the device and its capacity to detect gamma and X-rays.
  • Matović, Jelena (2019)
    Boron Neutron Capture Therapy is a binary cancer treatment based on the nuclear capture and fission reaction which occur when 10B is irradiated with low energy thermal neutrons. BNCT has throughout the years shown noticeable clinical results with the boron delivery agents that are currently available for testing. However, these delivery agents display deficiencies on multiple frontiers. My goal was to synthesize three different carbohydrate delivery agents for BNCT. Carbohydrate delivery agents have great potential for multiple reasons. They have low toxicity, high aqueous solubility and a high amount of boron atoms can be attached to a single molecule. These three synthesized molecules, 6-O-o-carboranylmethyl-D-glucopyranose, (O)-carboranylmethyl -D-glucopyranoside, (O)-carboranylmethyl -D-glucopyranoside, consist out of a glucose moiety and a carborane cage at both anomeric positions 1 as well as position 6. The synthetic pathways developed were 5-6 steps long and the overall yields varied between 13-15%. The synthesized molecules are currently undergoing biological evaluation.