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Browsing by Subject "publication bias"

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  • Julkaisuvinouma mindfulness-pohjaisia interventioita käsittelevässä tutkimuskirjallisuudessa 
    Pulkkinen, Tero (2019)
    Publication bias is one of the central threats to the validity of scientific research. In research of mindfulness-based interventions publication bias has been examined mostly in meta-analyses with statistical methods that have several limitations. This study examined how meta-analyses and systematic reviews that have examined publication bias have succeeded in their assessments. A rough estimate of publication bias and suggestions for further meta-analyses were made based on the examination. The study was conducted in the form of a literature review. It was found that there are significant limitations in examinations of publication bias, the most central of which being limited sample sizes, strong heterogeneity of studies and suboptimal method choices in meta-analyses and systematic reviews. The conclusions about publication bias also seemed overly optimistic in some cases. These limitations made it difficult to estimate the magnitude of publication bias. Regardless of that, there was evidence for the existence of publication bias, although in general it did not seem to lower the effect sizes of mindfulness-based interventions to zero. In future, publication bias should be assessed with methods less sensitive to the issues raised in this study. In addition, there is a need for pre-registered, good-quality replication studies of mindfulness-based interventions.
  • Masennuslääketutkimusten valikoiva julkaisu : Kirjallisuuskatsaus julkaisuharhasta 
    Mattila, Anni (2022)
    Objectives. The aim of the bachelor’s thesis was to examine how many studies of antidepressant trials remain unpublished and whether outcomes of published and unpublished trials differ – that is, whether the publication bias affects the publication of antidepressant studies. Publication bias occurs when positive or expected results are more likely to be published than negative or unexpected ones. The use of antidepressants is constantly increasing, which is why it is also important to study and make more transparent the reliability of related research. Methods. The study was conducted as a literature review. The final data of the study consisted of four peer-reviewed studies, which were searched in five different databases during May 2022. The analysis of the data was carried out qualitatively. Results and conclusions. The results of this study suggest that publication bias highlights the positive results of antidepressant trials. Less than a third of negative results end up being published, with almost all positive results being published. Thus, the available research does not really correspond to all the research that has been done, as a result of which the efficacy of antidepressants is probably judged to be better than the truth. Despite the actions taken to eradicate the bias, the phenomenon can still be considered a significant problem, although some improvement may have taken place.

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