Browsing by Subject "Neuroinflammation"

This thesis presents a comprehensive exploration of cerebral palsy, acknowledged as the predominant childhood disability. Traditionally viewed through a narrow lens as primarily a motor disorder, recent investigations have broadened this perception significantly. Beyond motor impairments, cerebral palsy manifests an array of comorbidities spanning sensory, emotional, social, and cognitive domains, reshaping our comprehension of its profound impact on individuals' lives. Challenging the static characterization long associated with cerebral palsy, contemporary research has unveiled a compelling dimension - persistent neuroinflammation. Contradicting the notion of a stable condition, these findings suggest potential progressive aspects. The revelation of persistent neuroinflammation prompts a fundamental reconsideration of cerebral palsy's nature. Should its etiological significance be established, it could revolutionise our understanding, suggesting a dynamic condition evolving over time. Conducted through a rigorous search across Pubmed and MEDLINE databases, this thesis stems from an exhaustive exploration of 900 articles. The literature review was conducted in accordance with the PRISM framework. The literature review provides a comprehensive foundation covering the historical context,pathophysiology, and neuropathology of cerebral palsy. Furthermore, it delves deeply into the aforementioned non-classical perspectives, shedding light on the multifaceted nature of this neurological condition. By synthesising classical and contemporary viewpoints, this study endeavours to broaden the discourse surrounding cerebral palsy, fostering a more inclusive and nuanced comprehension of its complexities. This thesis seeks to bridge the gap between traditional views of cerebral palsy as solely a motor disorder and the evolving understanding of its diverse manifestations across various domains. By integrating insights from multiple disciplines and challenging existing paradigms, it aims to contribute to a more holistic framework for conceptualising cerebral palsy. This integrated perspective aims to enhance not only our theoretical understanding but also the practical implications for interventions and support strategies tailored to the multifaceted needs of individuals living with cerebral palsy.